- 专利标题： HBV BINDING OLIGONUCLEOTIDES AND METHODS OF USE
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申请号： PCT/US2021/043182申请日： 2021-07-26
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公开(公告)号： WO2022026387A1公开(公告)日： 2022-02-03
- 发明人: HONG, Jin , BEIGELMAN, Leonid , BHATTACHARYA, Aneerban , DE COSTA, N. Tilani S.
- 申请人： ALIGOS THERAPEUTICS, INC.
- 申请人地址： 1 Corporate Drive, 2nd Floor
- 专利权人： ALIGOS THERAPEUTICS, INC.
- 当前专利权人： ALIGOS THERAPEUTICS, INC.
- 当前专利权人地址： 1 Corporate Drive, 2nd Floor
- 代理机构： SCHORR, Kristel et al.
- 优先权： US63/056,883 2020-07-27
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/712 ; A61K31/7115 ; A61P31/20 ; A61K31/713 ; A61K45/06 ; C12N15/1131 ; C12N2310/11 ; C12N2310/14 ; C12N2310/314 ; C12N2310/315 ; C12N2310/321 ; C12N2310/3231 ; C12N2310/3341 ; C12N2310/351 ; C12N2320/31
摘要：
Oligonucleotides that target hepatitis B virus (HBV) viral sequences, such as rcDNA, cccDNA, and HBV transcripts, are described herein. In addition, compositions and kits comprising such oligonucleotides are further described. Further disclosed herein are uses of such oligonucleotides and compositions to reduce rcDNA to cccDNA conversion, reduce cccDNA levels, and/or treat an HBV infection.
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