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公开(公告)号：WO2022269013A1
公开(公告)日：2022-12-29
申请号：PCT/EP2022/067290
申请日：2022-06-23
发明人： KIPPENBERGER, Stefan , STEINHORST, Katja , CINATL, Jindrich , BOJKOVA, Denisa , KÖNIG, Veronika , KLEEMANN, Johannes
IPC分类号： C12N15/113 , A61K31/7125 , C12N15/115 , C12N15/1131 , C12N2310/18 , C12N2310/315 , C12N2310/531
摘要： The invention relates to an oligonucleotide molecule having from 10 to 50 nucleotides comprising at least one G-quartet forming motif comprising 10 to 20 nucleotide residues, wherein at least 60% of said G-quartet forming motive forming residues are guanosine or deoxyguanosine residues, and wherein the molecule inhibits tumor growth and/or viral or bacterial replication and/or exerts anti-inflammatory effects in mammalian cells.
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公开(公告)号：WO2021195525A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/024406
申请日：2021-03-26
IPC分类号： C12N15/113 , C12N9/22 , A61P31/14 , C12N15/1131 , C12N2310/20 , C12N2320/11
摘要： The disclosure provides tandem arrays of CRISPR RNAs and methods of use.
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3.发明申请
公开(公告)号：WO2022229350A2
公开(公告)日：2022-11-03
申请号：PCT/EP2022/061404
申请日：2022-04-28
申请人： TIRMED PHARMA AB
发明人： SPETZ, Anna-Lena
IPC分类号： C12N15/11 , A61K31/7125 , A61K45/06 , A61P31/14 , A61P31/18 , A61P31/22 , C12N15/1131 , C12N2310/18 , C12N2310/315
摘要： The present disclosure relates to non-CpG single-stranded oligonucleotides (ssONs) with broad-spectrum antiviral activity for use in the treatment and/or prophylaxis of viral infections, such as Herpes simplex virus, Ebola virus, Lassa virus, Lyssa virus, rabies virus, measles virus, vesicular stomatitis virus (VSV), murine leukemia virus (MLV) and HIV-1, as well as multi-resistant HIV-1 infections, in a subject. Said ssONs have a length of at least 25 nucleotides and are stabilized by phosphorothioate internucleotide linkages and/or 2'-O-Methyl modifications.
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公开(公告)号：WO2022029209A1
公开(公告)日：2022-02-10
申请号：PCT/EP2021/071824
申请日：2021-08-05
IPC分类号： C12N15/113 , A61K31/713 , A61P31/20 , C12N15/1131 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/346 , C12N2310/351 , C12N2310/531 , C12N2320/31 , C12N2320/35
摘要： The present invention provides oligonucleotides for use in the treatment of hepatitis B or hepatitis B virus infection in a human patient.
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公开(公告)号：WO2021260233A1
公开(公告)日：2021-12-30
申请号：PCT/EP2021/067756
申请日：2021-06-28
IPC分类号： C12N15/113 , C12N15/1131 , C12N2310/11 , C12N2310/532
摘要： The present invention relates to an artificial RNA having at least one hybridization region against one or more target disruption structures of one or more RNA fragments, wherein such an artificial RNA suitable for disrupting by hybridization one or more target disruption structures of one or more RNA fragments, thereby modulating the functionality of the one or more RNA fragments.
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公开(公告)号：WO2021259244A1
公开(公告)日：2021-12-30
申请号：PCT/CN2021/101493
申请日：2021-06-22
申请人： 深圳霁因生物医药转化研究院
IPC分类号： C12N15/113 , A61K31/713 , A61P31/14 , C12N15/1131 , C12N2310/141 , C12N2310/531
摘要： 提供了一种抑制SARS-COV-2病毒复制的siRNA，shRNA及其编码DNA，以及包含该shRNA的药物和药物组合物。
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公开(公告)号：WO2021195519A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/024397
申请日：2021-03-26
IPC分类号： C12N15/113 , C12N9/22 , C12N15/62 , C07K14/005 , C12N15/86 , A61P31/14 , A61P31/16 , C12N15/1131 , C12N2310/20 , C12N2320/11 , C12N2740/16043 , C12N2760/16122 , C12N2770/20022
摘要： The disclosure provides CRISPR RNAs and methods of treating viral infections.
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公开(公告)号：WO2021195307A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/024038
申请日：2021-03-25
发明人： AKINC, Akin , MCININCH, James, D. , ANGLERO-RODRIGUEZ, Yesseinia , SCHLEGEL, Mark, K. , HEBNER, Christy, M. , LEMPP, Florian, A.
IPC分类号： C12N15/113 , A61K31/713 , C12N15/1131 , C12N2310/14 , C12N2310/312 , C12N2310/3125 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/343 , C12N2310/3515
摘要： The present invention relates to RNAi agents, e.g., dsRNA agents, targeting the coronavirus genome. The invention also relates to methods of using such RNAi agents to inhibit expression of a coronavirus genome and to methods of treating or preventing a coronavirus-associated disease in a subject.
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公开(公告)号：WO2021130589A1
公开(公告)日：2021-07-01
申请号：PCT/IB2020/061870
申请日：2020-12-13
IPC分类号： C12N15/115 , A61K49/00 , C12N15/1131 , C12N2310/16 , C12N2310/3517 , C12Q1/6886 , C12Q1/708 , C12Q2563/149 , C12Q2563/155 , C12Q2563/173
摘要： A composition for binding to human papillomavirus type 16 (HPV16)-positive tumor cells comprising a DNA aptamer comprising one of SEQ ID NO: 1 and SEQ ID NO: 2 is disclosed. The composition may further include at least one of a therapeutic tag and a diagnostic tag for in-vivo and in-vitro targeting of the HPVI6-positive tumor cells.
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10.发明申请
公开(公告)号：WO2021130266A1
公开(公告)日：2021-07-01
申请号：PCT/EP2020/087697
申请日：2020-12-22
发明人： GAO, Lu , ZHU, Yonghong , OTTOSEN, Søren , MUELLER, Henrik , ZHOU, Xue , BLAISING, Julie Elisabeth Françoise , JIN, Yuyan , BO, Qingyan , TYAGI, Gaurav
IPC分类号： C12N15/113 , A61K31/4375 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/554 , A61P31/12 , A61K31/7064 , A61K31/712 , A61P31/20 , A61K31/522 , A61K31/675 , A61K31/683 , A61K47/54 , A61K31/713 , A61K47/549 , C12N15/1131 , C12N2310/11 , C12N2310/14 , C12N2310/341 , C12N2320/31
摘要： The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of a therapeutic oligonucleotide targeting HBV and a TLR7 agonist for use in the treatment of a chronic hepatitis B patient.
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