A modular nuclear reactor system includes a lift-out, replaceable nuclear reactor core configured for replacement as a singular unit during a single lift-out event, such as rather than lifting and replacing individual fuel assemblies and/ or fuel elements. The system includes a reactor vessel and a power generation system configured to convert thermal energy in a high temperature working fluid received from the reactor vessel into electrical energy. The reactor vessel includes: a vessel inlet and an adjacent vessel outlet arranged near a bottom on the vessel; a vessel receptacle configured to receive a unified core assembly; locating datums in the base of the vessel receptacle and configured to constrain a core assembly in multiple degrees of freedom; and an interstitial zone surrounding the vessel receptacle and housing a set of control or moderating drums.