Invention Application
- Patent Title: RNAi CONSTRUCTS AND METHODS FOR INHIBITING MARC1 EXPRESSION
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Application No.: PCT/US2021/045784Application Date: 2021-08-12
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Publication No.: WO2022036126A2Publication Date: 2022-02-17
- Inventor: MURRAY, Justin K. , ZHANG, Jun , HOMANN, Oliver , LONG, Jason C. , MEADE, Bryan
- Applicant: AMGEN INC.
- Applicant Address: One Amgen Center Drive
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: One Amgen Center Drive
- Agency: PURCELL, Angela L.
- Priority: US63/065,190 2020-08-13
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/713 ; A61K31/7125 ; A61P1/16 ; C12N15/1137 ; C12N2310/14 ; C12N2310/315 ; C12N2310/317 ; C12N2310/332 ; C12N2310/343 ; C12N2310/346 ; C12N2320/11 ; C12N2320/30 ; C12Q1/6869
Abstract:
The present invention relates to RNAi constructs for reducing expression of the MARC1 gene. Methods of using such RNAi constructs to treat or prevent liver fibrosis and fatty liver diseases, such as nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, are also described.
Information query
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