- 专利标题： RNAi CONSTRUCTS AND METHODS FOR INHIBITING MARC1 EXPRESSION
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申请号： PCT/US2021/045784申请日： 2021-08-12
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公开(公告)号： WO2022036126A2公开(公告)日： 2022-02-17
- 发明人: MURRAY, Justin K. , ZHANG, Jun , HOMANN, Oliver , LONG, Jason C. , MEADE, Bryan
- 申请人： AMGEN INC.
- 申请人地址： One Amgen Center Drive
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： One Amgen Center Drive
- 代理机构： PURCELL, Angela L.
- 优先权： US63/065,190 2020-08-13
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/713 ; A61K31/7125 ; A61P1/16 ; C12N15/1137 ; C12N2310/14 ; C12N2310/315 ; C12N2310/317 ; C12N2310/332 ; C12N2310/343 ; C12N2310/346 ; C12N2320/11 ; C12N2320/30 ; C12Q1/6869
摘要：
The present invention relates to RNAi constructs for reducing expression of the MARC1 gene. Methods of using such RNAi constructs to treat or prevent liver fibrosis and fatty liver diseases, such as nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, are also described.
IPC分类:
