公开(公告)号：WO2023076318A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/047790

申请日：2022-10-26

Applicant: AMGEN INC.

Inventor： KHODABANDEHLOU, Hamid ,  WANG, Tony, Y. ,  TULSYAN, Aditya ,  SCHORNER, Gregory, L.

IPC: G01N21/359 ,  G01N21/65 ,  G01J3/00 ,  G01J3/02 ,  G01J3/08 ,  G01N30/02 ,  G06N3/08

Abstract: A method (500) for monitoring and/or controlling a pharmaceutical process includes obtaining (502) one-dimensional spectral data generated by a spectroscopy system (e.g., a Raman spectroscopy system), converting (508) the one-dimensional spectral data to a two-dimensional spectral data matrix, and applying the two-dimensional spectral data matrix to an input layer of a deep learning model (e.g., a convolutional neural network). The deep learning model predicts (410) a parameter (e.g., metabolite level) based on the two-dimensional spectral data matrix, e.g., in order to monitor and/or control a pharmaceutical process.

公开(公告)号：WO2023069754A2

公开(公告)日：2023-04-27

申请号：PCT/US2022/047491

申请日：2022-10-21

Applicant: AMGEN INC.

Inventor： RULIFSON, Ingrid ,  MEADE, Bryan ,  LONG, Jason C. ,  MURRAY, Justin K.

IPC: C12N15/113 ,  C12N9/10 ,  A61K31/713 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61P1/16 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/343 ,  C12N2310/351 ,  C12N2320/11 ,  C12N2320/32

Abstract: The disclosure relates to RNAi constructs, such as siRNA, for reducing expression of the GPAM gene. Methods of using such RNAi constructs to treat or prevent liver disease, such as nonalcoholic fatty liver disease (NAFLD), are also described.

公开(公告)号：WO2023069401A1

公开(公告)日：2023-04-27

申请号：PCT/US2022/046974

申请日：2022-10-18

Applicant: AMGEN INC.

Inventor： ALKHALIFA, Saleh ,  VAGLE, Daniel ,  OZYURT, Furkan ,  BAYRAK, Elif Seyma

IPC: G06N3/0442 ,  G06N3/045 ,  G06N3/09 ,  G06N3/048 ,  G06N3/092

Abstract: In systems and methods for processing regulatory questions, textual data representing regulatory questions is obtained by one or more processors. The systems and methods also use one or more natural language processing models to classify the regulatory questions, generate answers to the regulatory questions, generate summaries of the regulatory questions, and/or identify documents that are similar to the regulatory questions. The systems and methods also store, transmit, and/or display data indicative of the classifications, answers, summaries, and/or similar documents.

公开(公告)号：WO2023064119A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/045303

申请日：2022-09-30

Applicant: AMGEN INC.

Inventor： MOGHADDAM, Seyed, Reza Mirhassani ,  JAZAYERI, Julian ,  SANCHEZ, Sandra ,  HALILI, Edgardo ,  SALDANA, Cindy ,  VALENZUELA, Sergio, Giovanni

IPC: A61M5/142 ,  A61M5/48

Abstract: Apparatuses, systems and methods are provided that characterize a rear sub-assembly for an autoinjector (Al). Apparatuses, systems and methods are also provided that generate injection time (IT) models for autoinjectors (Als). Autoinjectors (Als) (e.g., mechanical Als, spring-loaded Als, etc.), components for use within Als (e.g., prefilled syringes (PFS), rear sub-assemblies (RSAs), etc.), and related methods may utilize mathematical modeling along with design for six sigma (DFSS) and design for reliability and manufacturability (D RM) to establish upstream controls that ensure injection time (IT) robustness of mechanical autoinjectors (Als). For example, break-loose and extrusion (BLE) alert limit, rear sub-assembly (RSA) area under the curve (AUG), and RSA minimum force.

公开(公告)号：WO2023034786A1

公开(公告)日：2023-03-09

申请号：PCT/US2022/075648

申请日：2022-08-30

Applicant: AMGEN INC.

Inventor： ARUNACHALAMPILLAI, Athimoolam ,  CROCKETT, Richard, David ,  FARRELL, Robert, P. ,  JUDD, Ted, Charles ,  ORTIZ, Adrian ,  ROBINSON, Joanna ,  WEI, Carolyn, S. ,  YAMAMOTO, Kumiko ,  FAGER, Diana, Catherine ,  JOHNSON, Heather, Claire ,  LANGILLE, Neil, Fred ,  ZHANG, Liang

IPC: C07D265/30 ,  C07D491/147

Abstract: The disclosure provides processes for preparing Compound A, Compound E, Compound I, salts thereof, and/or stereoisomers thereof, as described herein.

公开(公告)号：WO2023018870A1

公开(公告)日：2023-02-16

申请号：PCT/US2022/040056

申请日：2022-08-11

Applicant: AMGEN INC.

Inventor： BALL, Nicole ,  SLOEY, Christopher ,  LUERAS, Alexis ,  QIAN, Rulin

IPC: A61K39/395 ,  A61K9/08 ,  A61K47/18 ,  C07K16/24

Abstract: Provided herein are liquid compositions comprising a high concentration of a monoclonal antibody, e.g., greater than about 100 mg/mL, which demonstrate storage -stability and reduced viscosity. In exemplary embodiments, the liquid composition comprises about less than about 400 mM arginine glutamate, and, in alternative exemplary embodiments, the liquid composition comprises proline and a buffer.

公开(公告)号：WO2023018812A1

公开(公告)日：2023-02-16

申请号：PCT/US2022/039971

申请日：2022-08-10

Applicant: AMGEN INC.

Inventor： YAMANO, Michael M. ,  LI, Yunxiao ,  NAVARATNE, Primali ,  MEDINA, Jose ,  CHEN, Ning ,  PETTUS, Liping ,  RAHIMOFF, Rene ,  LI, Xiaofen ,  STELLWAGEN, John ,  MANONI, Francesco ,  LI, Kexue ,  LANMAN, Brian Alan ,  WURZ, Ryan Paul ,  ZHAO, Wei ,  RUI, Huan ,  ESHON, Josephine

IPC: A61K31/33 ,  A61K31/395 ,  A61K31/519

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula (I) : wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

公开(公告)号：WO2022260981A1

公开(公告)日：2022-12-15

申请号：PCT/US2022/032308

申请日：2022-06-06

Applicant: AMGEN INC.

Inventor： CONNER, Jeremy, S. ,  WHETSTONE, Sarah ,  KUMAR, Ketan

IPC: C12M1/36 ,  C12M1/34

Abstract: A method of cell culture assessment (e.g., prior to a drug substance harvesting process) includes obtaining a plurality of parameters associated with a cell culture, and inferring or predicting a value or classification indicative of packed cell volume. Inferring or predicting the packed cell volume includes applying the plurality of parameters as inputs to a non-linear machine learning model. The method also includes generating an output indicative of the inferred or predicted value or classification.

公开(公告)号：WO2022256563A1

公开(公告)日：2022-12-08

申请号：PCT/US2022/032011

申请日：2022-06-02

Applicant: AMGEN INC. ,  AMGEN RESEARCH (MUNICH) GMBH

Inventor： PIERCE, Nathan William ,  KIELCZEWSKA, Agnieszka ,  CHEN, Wentao ,  NOLAN-STEVAUX, Olivier ,  BATES, Darren L. ,  WINKEL, Lisa ,  DAHLHOFF, Christoph ,  RAUM, Tobias ,  BLUEMEL, Claudia ,  HONER, Jonas Karl-Josef

IPC: C07K16/28 ,  A61K39/00 ,  A61K2039/507 ,  C07K16/2818 ,  C07K16/2866 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/569 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92

Abstract: The present invention provides anti-CCR8 antibodies and antigen-binding fragments thereof, and methods of making and using said anti-CCR8 antibodies and antigen-binding fragments thereof.

公开(公告)号：WO2022256559A1

公开(公告)日：2022-12-08

申请号：PCT/US2022/032006

申请日：2022-06-02

Applicant: AMGEN RESEARCH (MUNICH) GMBH ,  AMGEN INC.

Inventor： BROZY, Johannes ,  DAHLHOFF, Christoph ,  RAUM, Tobias ,  PENDZIALEK, Jochen, S. ,  WINKEL, Lisa ,  MUENZ, Markus ,  PIERCE, Nathan, William ,  KIELCZEWSKA, Agnieszka ,  CHEN, Wentao ,  BATES, Darren, L. ,  BLUEMEL, Claudia ,  HONER, Jonas, Karl-Josef

IPC: C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2866 ,  C07K16/2887 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention provides single chain T cell engager (TCE) molecules having an scFab that binds a target antigen and an scFv that binds CD3, and TCE molecules that bind CCR8 and CD3. Methods of treating cancer are also provided.