- 专利标题： POTENT AND SELECTIVE INHIBITORS OF HER2
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申请号： PCT/US2021/053368申请日： 2021-10-04
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公开(公告)号： WO2022076304A1公开(公告)日： 2022-04-14
- 发明人: GRAY, Nathanael S. , HATCHER, John M. , VERANO, Alyssa
- 申请人： DANA-FARBER CANCER INSTITUTE, INC. , GRAY, Nathanael S. , HATCHER, John M. , VERANO, Alyssa
- 申请人地址： 450 Brookline Avenue; 26 Greenview Avenue; 2 Glover Court; Longwood Center
- 专利权人： DANA-FARBER CANCER INSTITUTE, INC.,GRAY, Nathanael S.,HATCHER, John M.,VERANO, Alyssa
- 当前专利权人： DANA-FARBER CANCER INSTITUTE, INC.,GRAY, Nathanael S.,HATCHER, John M.,VERANO, Alyssa
- 当前专利权人地址： 450 Brookline Avenue; 26 Greenview Avenue; 2 Glover Court; Longwood Center
- 代理机构： TRINQUE, Brian C.
- 优先权： US63/087,517 2020-10-05
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/4025 ; A61K31/519 ; C07D207/04 ; C07D487/00 ; C07D487/04
摘要：
Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that that are potent and selective inhibitors of HER2. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with HER2.
