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公开(公告)号：WO2021173677A1
公开(公告)日：2021-09-02
申请号：PCT/US2021/019424
申请日：2021-02-24
申请人： DANA-FARBER CANCER INSTITUTE, INC. , HATCHER, John M. , GRAY, Nathanael S. , JIANG, Baishan , ZHANG, Tinghu , CHE, Jianwei , GAO, Yang , JONES, Lyn Howard
发明人： HATCHER, John M. , GRAY, Nathanael S. , JIANG, Baishan , ZHANG, Tinghu , CHE, Jianwei , GAO, Yang , JONES, Lyn Howard
IPC分类号： A61K31/505 , A61K31/506 , A61K31/445 , A61K47/55 , A61P35/00 , A61K31/5025 , C07D487/04
摘要： Disclosed are bispecific compounds (degraders) that target ALK or ALK and FAK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the bispecific compounds to treat diseases and disorders characterized or mediated by aberrant ALK or ALK and FAK activity.
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公开(公告)号：WO2022076304A1
公开(公告)日：2022-04-14
申请号：PCT/US2021/053368
申请日：2021-10-04
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/519 , C07D207/04 , C07D487/00 , C07D487/04
摘要： Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that that are potent and selective inhibitors of HER2. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with HER2.
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公开(公告)号：WO2019046775A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/049186
申请日：2018-08-31
发明人： HATCHER, John M. , GRAY, Nathanael S. , JANG, Jaebong , DE CLERCQ, Dries , JANNE, Pasi , SAXON, James A. , ECK, Michael
IPC分类号： C07D471/04 , C07D487/04 , A61P35/00
摘要： The application relates to a compound having Formula X: which modulates the activity of HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, plays a role.
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