- 专利标题： COMPOUNDS TARGETING Y220C MUTANT OF P53
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申请号： PCT/CN2022/085296申请日： 2022-04-06
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公开(公告)号： WO2022213975A1公开(公告)日： 2022-10-13
- 发明人: LI, Sujing , LI, Amin , ZHENG, Qian , DANG, Chaojie , FAN, Xinrui , LONG, Wei , WANG, Yanping
- 申请人： JACOBIO PHARMACEUTICALS CO., LTD.
- 申请人地址： Unit 2
- 专利权人： JACOBIO PHARMACEUTICALS CO., LTD.
- 当前专利权人： JACOBIO PHARMACEUTICALS CO., LTD.
- 当前专利权人地址： Unit 2
- 优先权： CNPCT/CN2021/085870 2021-04-08
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; A61K31/454 ; C07D209/04 ; A61P35/00
摘要：
Provided are compounds of formula (I) which can bind to p53 mutant and restore its ability to bind DNA and activate downstream effects involved in tumor suppression. Also provided are the synthesis processes and use of the compounds.
IPC分类:
