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公开(公告)号：WO2022078416A1
公开(公告)日：2022-04-21
申请号：PCT/CN2021/123674
申请日：2021-10-14
发明人： LI, Runze , MA, Cunbo , LIAN, Zhenchang , XIONG, Jing , WANG, Yanping , LONG, Wei
IPC分类号： C07C227/14 , C07D209/10 , C07F9/06 , C07D317/40 , A61K31/66 , A61K31/404 , A61P35/00
摘要： Glutamine analogs, a composition containing the glutamine analogs and the use thereof.
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公开(公告)号：WO2023020523A1
公开(公告)日：2023-02-23
申请号：PCT/CN2022/112931
申请日：2022-08-17
发明人： YANG, Hongwei , MA, Cunbo , GAO, Panliang , HAN, Huifeng , WANG, Peng , LI, Runze , LIU, Xiaoyu , WANG, Yanping , LONG, Wei , ZHANG, Wei
IPC分类号： C07D403/14 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/4375 , A61P35/00
摘要： A compound of Formula (I), (II) or (III), stereoisomer thereof, pharmaceutically acceptable salt thereof, pharmaceutically acceptable salt of the stereoisomer are disclosed.
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公开(公告)号：WO2023020521A1
公开(公告)日：2023-02-23
申请号：PCT/CN2022/112927
申请日：2022-08-17
发明人： YANG, Hongwei , MA, Cunbo , GAO, Panliang , HAN, Huifeng , WANG, Peng , LI, Runze , LIU, Xiaoyu , WANG, Yanping , LONG, Wei , ZHANG, Wei
IPC分类号： C07D471/04 , A61K31/519 , A61K31/517 , A61P35/00
摘要： The invention relates to a compound of Formula (I), stereoisomer thereof, pharmaceutically acceptable salt thereof, pharmaceutically acceptable salt of the stereoisomer thereof, prodrug thereof, deuterated molecule thereof or conjugated form thereof; composition containing the same and the use thereof.
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公开(公告)号：WO2022078462A1
公开(公告)日：2022-04-21
申请号：PCT/CN2021/123878
申请日：2021-10-14
发明人： LI, Runze , MA, Cunbo , LIAN, Zhenchang , XIONG, Jing , WANG, Yanping , LONG, Wei
IPC分类号： C07C227/14 , C07D209/10 , C07F9/06 , C07D317/40 , A61K31/66 , A61K31/404 , A61P35/00
摘要： Glutamine analogs are provided, a composition containing the glutamine analogs and the use thereof.
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公开(公告)号：WO2023016434A1
公开(公告)日：2023-02-16
申请号：PCT/CN2022/111050
申请日：2022-08-09
发明人： LI, Sujing , LI, Amin , ZHENG, Qian , DANG, Chaojie , FAN, Xinrui , LONG, Wei , WANG, Yanping
IPC分类号： C07D333/66 , C07D409/12 , C07D419/14 , A61K31/381 , A61P35/00
摘要： Provided are compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are pharmaceutical compositions comprising the compounds, methods of preparing the compounds and the use in the manufacture of medicaments for preventing or treating a disease or condition related to p53 mutants.
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公开(公告)号：WO2023005957A1
公开(公告)日：2023-02-02
申请号：PCT/CN2022/108128
申请日：2022-07-27
发明人： LI, Haijun , YANG, Guiqun , LONG, Wei , WANG, Yanping
IPC分类号： C07D401/14 , A61K31/4545 , A61P35/00
摘要： Provided herein are salts of the compound 1 and new polymorph forms thereof, pharmaceutical composition including the compound 1 and new polymorph forms thereof, and methods of preparing them and using them.
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公开(公告)号：WO2022206725A1
公开(公告)日：2022-10-06
申请号：PCT/CN2022/083557
申请日：2022-03-29
发明人： YE, Yang , LI, Xiuwei , YANG, Guiqun , YAN, Fashun , WANG, Yanping , LONG, Wei
IPC分类号： C07D333/56 , C07D209/44 , C07D417/12 , C07D495/04 , C07D277/62 , A61K31/381 , A61K31/4035 , A61P35/00
摘要： Compounds of general Formula I, II, III, IV, V and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.
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公开(公告)号：WO2022213975A1
公开(公告)日：2022-10-13
申请号：PCT/CN2022/085296
申请日：2022-04-06
发明人： LI, Sujing , LI, Amin , ZHENG, Qian , DANG, Chaojie , FAN, Xinrui , LONG, Wei , WANG, Yanping
IPC分类号： A61K31/404 , A61K31/454 , C07D209/04 , A61P35/00
摘要： Provided are compounds of formula (I) which can bind to p53 mutant and restore its ability to bind DNA and activate downstream effects involved in tumor suppression. Also provided are the synthesis processes and use of the compounds.
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公开(公告)号：WO2022199677A1
公开(公告)日：2022-09-29
申请号：PCT/CN2022/082908
申请日：2022-03-25
发明人： YE, Yang , LI, Xiuwei , YANG, Guiqun , YAN, Fashun , WANG, Yanping , LONG, Wei
IPC分类号： C07D209/44 , C07D401/12 , A61K31/4035 , A61P35/00
摘要： Compounds of general Formula S-1, S-2, S-3 and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.
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公开(公告)号：WO2022184178A1
公开(公告)日：2022-09-09
申请号：PCT/CN2022/079487
申请日：2022-03-07
发明人： HAN, Huifeng , GAO, Panliang , MA, Cunbo , WANG, Peng , LONG, Wei , WANG, Yanping , ZHANG, Hao , LIU, Dan
IPC分类号： C07D471/00 , C07D471/02 , C07D471/04 , C07D487/04 , C07D519/00 , C07D491/048 , A61K31/435 , A61K31/4375 , A61K31/517 , A61P35/00
摘要： Provided are KRAS G12D inhibitors of formula (I) or formula (IV), a composition containing the inhibitor and the use thereof.
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