发明申请
- 专利标题： LIVER X RECEPTOR MODULATORS
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申请号： PCT/US2022/072213申请日： 2022-05-09
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公开(公告)号： WO2022241404A1公开(公告)日： 2022-11-17
- 发明人: MICALIZIO, Glenn C. , BURRIS, Thomas
- 申请人： TRUSTEES OF DARTMOUTH COLLEGE
- 申请人地址： 11 Rope Ferry Road
- 专利权人： TRUSTEES OF DARTMOUTH COLLEGE
- 当前专利权人： TRUSTEES OF DARTMOUTH COLLEGE
- 当前专利权人地址： 11 Rope Ferry Road
- 代理机构： O'CONNOR, Kevin A.
- 优先权： US63/187,382 2021-05-11
- 主分类号： A61K47/28
- IPC分类号： A61K47/28 ; A61K31/56 ; A61K31/58 ; A61P5/26
摘要：
The present disclosure relates to polycyclic (e.g., fused tetracyclic) liver X receptor (LXR) modulators, synthetic methods for preparing such LXR modulators, and methods of using such LXR modulators to treat a disease or condition that would benefit from LXR modulation. Exemplary compounds have quaternary centers at C9 and C13 and a substituted sulfonamide moiety at C16.
