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    MYC:TRRAP INHIBITORS AND USES THEREOF
    1.
    发明申请
    MYC:TRRAP INHIBITORS AND USES THEREOF 审中-公开

    公开(公告)号：WO2023028508A2

    公开(公告)日：2023-03-02

    申请号：PCT/US2022/075378

    申请日：2022-08-24

    申请人： TRUSTEES OF DARTMOUTH COLLEGE

    发明人： FERIS, Edmond J. ,  COLE, Michael D.

    IPC分类号： A61K41/00

    摘要： The present disclosure relates to inhibitors of the MYC:TRRAP interaction and their use in the prevention or treatment of cancer and disclosed. Disclosed compounds include 3,9-Dihydroxy-4-prenyl-[6aR;11aR]pterocarpan, N-[4-(diethylamino)benzyl]-1-(methylsulfonyl)-3-(pyridin-3-yl)-1H-1,2,4-triazol-5-amine, and N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide.

    LIVER X RECEPTOR MODULATORS
    2.
    发明申请
    LIVER X RECEPTOR MODULATORS 审中-公开

    公开(公告)号：WO2022241404A1

    公开(公告)日：2022-11-17

    申请号：PCT/US2022/072213

    申请日：2022-05-09

    申请人： TRUSTEES OF DARTMOUTH COLLEGE

    发明人： MICALIZIO, Glenn C. ,  BURRIS, Thomas

    IPC分类号： A61K47/28 ,  A61K31/56 ,  A61K31/58 ,  A61P5/26

    摘要： The present disclosure relates to polycyclic (e.g., fused tetracyclic) liver X receptor (LXR) modulators, synthetic methods for preparing such LXR modulators, and methods of using such LXR modulators to treat a disease or condition that would benefit from LXR modulation. Exemplary compounds have quaternary centers at C9 and C13 and a substituted sulfonamide moiety at C16.

    LOW POWER ANALOG CIRCUITRY FOR ARTIFICIAL NEURAL NETWORKS
    3.
    发明申请
    LOW POWER ANALOG CIRCUITRY FOR ARTIFICIAL NEURAL NETWORKS 审中-公开

    公开(公告)号：WO2022232196A1

    公开(公告)日：2022-11-03

    申请号：PCT/US2022/026416

    申请日：2022-04-26

    申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

    发明人： ODAME, Kofi

    IPC分类号： G06N3/06 ,  G06F17/16 ,  G06N3/02 ,  G06N3/04 ,  G10L21/0208

    摘要： A low power analog Long Short-Term Memory (LSTM) recurrent neural network has an input layer, an array of Adaptive Filter Unit for Analog LSTM, a linear projection layer, and an output layer. The output layer has multiple nonlinear amplifiers, a nonlinear element with a sigmoidal input-output characteristic function, and a time-constant adjustable, nonlinear, low pass filter that provides the memory function of the LSTM. The LSTM memory is used with mismatch-robust weights determined by learning by computation of optimal weights values, wherein the objective function minimizes misdetection probability, and used to process a signal to detect events.

    GENERATING FAKE DOCUMENTS USING WORD EMBEDDINGS TO DETER INTELLECTUAL PROPERTY THEFT
    5.
    发明申请
    GENERATING FAKE DOCUMENTS USING WORD EMBEDDINGS TO DETER INTELLECTUAL PROPERTY THEFT 审中-公开

    公开(公告)号：WO2022146921A1

    公开(公告)日：2022-07-07

    申请号：PCT/US2021/065209

    申请日：2021-12-27

    申请人： TRUSTEES OF DARTMOUTH COLLEGE

    发明人： SUBRAHMANIAN, Venkatramanan, S. ,  ABDIBAYEV, Almas ,  CHEN, Dongkai ,  CHEN, Haipeng ,  POLURI, Deepti

    IPC分类号： G07D7/20 ,  G06K9/62

    摘要： A computer-implemented method, system and computer program product for generating fake documents. A corpus of domain specific documents is built and word embeddings for each word in such documents are identified as embedding vectors. Concepts in the corpus are then clustered together by clustering the embedding vectors. A feasible candidate replacement set is generated for each concept using the clustered concepts in the corpus. After such pre-processing steps are accomplished, concepts are extracted from a document. The concept importance values are computed for these extracted concepts, in which the extracted concepts are clustered into bins based on such measurements. A joint optimization problem is solved to identify both the concepts in the document to be replaced using the clustered concepts in the bins as well as the corresponding replacement concepts obtained from the clustered concepts in the corpus. Such replacements are made to generate a fake document.

    CYCLODEXTRIN-BASED POLYROTAXANES AND PROTEIN HYBRIDS AS THREE-DIMENSIONAL PRINTING INKS
    9.
    发明申请
    CYCLODEXTRIN-BASED POLYROTAXANES AND PROTEIN HYBRIDS AS THREE-DIMENSIONAL PRINTING INKS 审中-公开

    公开(公告)号：WO2021226567A1

    公开(公告)日：2021-11-11

    申请号：PCT/US2021/031495

    申请日：2021-05-10

    申请人： TRUSTEES OF DARTMOUTH COLLEGE

    发明人： KE, Chenfeng ,  LIN, Qianming ,  LI, Longyu ,  TANG, Miao

    IPC分类号： C08G83/00 ,  C08L5/16 ,  G01N33/58

    摘要： Embodiments of the present disclosure pertain to a composition that includes a rotaxane. The rotaxane includes a plurality of macrocyclic rings and a polymer with a molecular weight below 10,000 Da that is covalently appended to one or more sterically hindered molecules. The cavities of the macrocyclic rings are threaded onto the polymer. The plurality of threaded macrocyclic rings include a plurality of different segments that each include a plurality of threaded macrocyclic rings. Each of the plurality of different segments is in the form of a crystalline network. Further embodiments of the present disclosure pertain to methods of forming the rotaxanes by covalently appending one or more sterically hindered molecules onto a polymer and threading a plurality of macrocyclic rings onto the polymer. Additional embodiments of the present disclosure pertain to methods of manufacturing a three-dimensional structure by applying a composition of the present disclosure onto a surface.

    DIELECTRIC TRANSMISSION PROBES AND METHODS OF USING THE SAME
    10.
    发明申请
    DIELECTRIC TRANSMISSION PROBES AND METHODS OF USING THE SAME 审中-公开

    公开(公告)号：WO2021067802A1

    公开(公告)日：2021-04-08

    申请号：PCT/US2020/054065

    申请日：2020-10-02

    申请人： TRUSTEES OF DARTMOUTH COLLEGE

    发明人： MEANEY, Paul ,  RAYNOLDS, Timothy ,  AUGUSTINE, Robin

    IPC分类号： A61B5/055 ,  A61B5/053 ,  G01N22/00

    摘要： Embodiments of the present disclosure pertain to transmission dielectric probes with at least one channel that extends across the probe. The channel includes a first opening on a first side of the transmission dielectric probe, and a second opening on a second side of the transmission dielectric probe. The first opening and the second opening are on opposite ends of the transmission dielectric probe, and the second opening is associated with an outer surface of the transmission dielectric probe. Additionally, the first opening and the second opening have different diameters, different geometries, or combinations thereof. Further embodiments pertain to methods of operating the transmission dielectric probes by placing the outer surface of the transmission dielectric probe on a surface of an object, transmitting a signal from a first channel through the surface and into the object, and receiving the transmitted signal back through a second channel.