- 专利标题: PYRIDINE DERIVATIVES AND THEIR USE AS SODIUM CHANNEL ACTIVATORS
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申请号: PCT/US2022/044559申请日: 2022-09-23
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公开(公告)号: WO2023049364A1公开(公告)日: 2023-03-30
- 发明人: LOFSTRAND, Verner , KIM, Jung Yun , CLEMENT, Helen , CHARIFSON, Paul , JOHNSTONE, Shawn , SABBATANI, Juliette , SCHOLTES, Jan Felix , ZHANG, Wei , SUN, Shaoyi , BURFORD, Kristen
- 申请人: XENON PHARMACEUTICALS INC.
- 申请人地址: 200 - 3650 Gilmore Way
- 专利权人: XENON PHARMACEUTICALS INC.
- 当前专利权人: XENON PHARMACEUTICALS INC.
- 当前专利权人地址: 200 - 3650 Gilmore Way
- 代理机构: LIGON, Toby, J. et al.
- 优先权: US63/248,330 2021-09-24
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; C07D471/04 ; C07D491/04 ; C07D413/14 ; A61K31/4439 ; A61P25/08
摘要:
The present disclosure is directed to compounds of formula (I):; wherein X, Y, R1, R2 and R3 are as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.