A closed-loop artificial pancreas insulin infusion control system, including a detection module (100) configured to the current blood glucose level G; a program module (101), connected to the detection module (100), preset with a compound artificial pancreas algorithm, including a first algorithm and a second algorithm. The first algorithm is used to calculate the first insulin infusion amount I 1, the second algorithm is used to calculate the second insulin infusion amount I 2, and the compound artificial pancreas algorithm further optimises I 1 and I 2 to obtain the final insulin infusion amount I 3; and an infusion module (102), connected to the program module (101), the program module (101) sends the final insulin infusion amount I 3 to the infusion module (102), the infusion module (102) is configured to infuse insulin according to the final insulin infusion amount I 3. Through further optimisation of the first insulin infusion amount I 1 and the second insulin infusion amount I 2, the final infusion result is more accurate and reliable, realising precise control of the closed-loop artificial pancreatic insulin infusion control system.