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1.发明申请
公开(公告)号：WO2023086482A1
公开(公告)日：2023-05-19
申请号：PCT/US2022/049564
申请日：2022-11-10
申请人： AITA BIO INC.
摘要： A device for delivering medicament to a user is disclosed. The device comprises a reservoir for storing medicament; an infusion catheter fluidly communicating with the reservoir to deliver the medicament into a subcutaneous layer of the user; a pump fluidly communicating with the reservoir and infusion catheter for pumping the medicament from the reservoir though the infusion catheter; an introducer needle movable within the infusion catheter, the introducer needle configured to facilitate (a) insertion of the infusion catheter into a subcutaneous layer of the user and (b) retraction of the introducer needle after insertion of the infusion catheter to enable delivery of medicament through the infusion catheter; and a sensor for continuously monitoring glucose level in the user, wherein the sensor is configured to (a) engage the introducer needle and/or the infusion catheter and (b) simultaneously advance along with the infusion catheter during the insertion into the subcutaneous layer of the user by the introducer needle.
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公开(公告)号：WO2023081239A1
公开(公告)日：2023-05-11
申请号：PCT/US2022/048748
申请日：2022-11-02
申请人： BETA BIONICS, INC.
IPC分类号： A61B5/00 , A61B5/145 , A61M5/142 , A61M5/172 , G16H40/60 , G16H50/20 , G16H50/30 , G16H50/70
摘要： A glucose level control system (GLCS) may be configured to determine a long-acting insulin dose recommendation based at least in part on a therapy of fast-acting insulin provided to a subject during a therapy period. The GLCS may be configured to operate in multiple operating modes with each operating mode configured to provide glucose control therapy for a different glycemic dysregulation condition (e.g., type-1 or type-2 diabetes). The GLCS may be configured to determine a recommended medicament dose based at least in part on therapy data and/or user-specified medicament related inputs, which may include qualitative meal announcements. The dose of medicament may be modified by the GLCS before the subject experiences a hypoglycemic event. The GLCS may generate a therapy management data set and perform a therapy management support process including generation of an excursion dosing threshold value or a backup therapy protocol.
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公开(公告)号：WO2023075956A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/044410
申请日：2022-09-22
申请人： CAREFUSION 303, INC.
摘要： A mini peristaltic pump is provided that includes a base plate, first and second gears disposed on a first side of the base plate, first and second roller wheels disposed on a second side of the base plate and coupled to the first and second gears, respectively, and one or more rollers coupled to each of the first and second roller wheels. A motor is coupled to the first gear, the motor configured to rotate the first gear and the first roller wheel to move the one or more rollers coupled to the first roller wheel in a first orbital path to peristaltically engage and compress a hand pump disposed between the first and second roller wheels. A profile feature on the base may be provided instead of the second gear and roller wheel. Systems and methods are also provided.
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公开(公告)号：WO2023070715A1
公开(公告)日：2023-05-04
申请号：PCT/CN2021/128610
申请日：2021-11-04
发明人： YANG, Cuijun
摘要： A closed-loop artificial pancreas insulin infusion control system, including a detection module (100), configured to detect the current blood glucose level G continuously; a program module (101), connected to the detection module (100), and preset with a hybrid artificial pancreas algorithm, used for calculating the insulin infusion amount required by the user, the hybrid artificial pancreas algorithm includes a cPID algorithm and/or a cMPC algorithm, where the input of the cPID algorithm is the intermediate value of the MPC algorithm, and the input of the cMPC algorithm is the output value of the PID algorithm; and an infusion module (102), connected to the program module (101), and is controlled by the program module (101) to infuse insulin according to the insulin infusion amount calculated by the hybrid artificial pancreas algorithm. Through the in-depth combination of PID algorithm and MPC algorithm, make full use of the advantages of PID algorithm and MPC algorithm to make the infusion result more accurate and reliable, and realize the precise control of the closed-loop artificial pancreatic insulin infusion system.
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公开(公告)号：WO2023070247A1
公开(公告)日：2023-05-04
申请号：PCT/CN2021/126014
申请日：2021-10-25
发明人： YANG, Cuijun
摘要： A closed-loop artificial pancreas insulin infusion control system, including a detection module (100) configured to the current blood glucose level G; a program module (101), connected to the detection module (100), preset with a compound artificial pancreas algorithm, including a first algorithm and a second algorithm. The first algorithm is used to calculate the first insulin infusion amount I 1, the second algorithm is used to calculate the second insulin infusion amount I 2, and the compound artificial pancreas algorithm further optimises I 1 and I 2 to obtain the final insulin infusion amount I 3; and an infusion module (102), connected to the program module (101), the program module (101) sends the final insulin infusion amount I 3 to the infusion module (102), the infusion module (102) is configured to infuse insulin according to the final insulin infusion amount I 3. Through further optimisation of the first insulin infusion amount I 1 and the second insulin infusion amount I 2, the final infusion result is more accurate and reliable, realising precise control of the closed-loop artificial pancreatic insulin infusion control system.
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公开(公告)号：WO2023069342A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/046843
申请日：2022-10-17
发明人： O'REILLY, Simon , LI, Kun , COREY, Scott
摘要： A method of pressure management of a drug delivery device including a pump, a fluid line, and a power source, includes: actuating the pump a predetermined number of cycles to move fluid through the fluid line, wherein the predetermined number of cycles is greater than one; determining an estimated pressure value within the fluid line for each cycle of the predetermined number of cycles; and determining a baseline pressure level comprising an average of the estimated pressure values.
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公开(公告)号：WO2023064662A1
公开(公告)日：2023-04-20
申请号：PCT/US2022/076539
申请日：2022-09-16
申请人： ICU MEDICAL, INC.
摘要： Disclosed in some embodiments is an electronic intravenous infusion pump provided with a disposable, insertable pump cartridge that is connectable to one or more intravenous fluid infusion sources, wherein a user interface on a touch display screen interacts with and responds to the user's insertion of the cassette, and/or wherein the pump is enabled to program a course of infusion for a patient based upon information obtained from the inserted cassette and/or the one or more fluid infusion sources connected to the cassette.
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公开(公告)号：WO2023064342A1
公开(公告)日：2023-04-20
申请号：PCT/US2022/046385
申请日：2022-10-12
摘要： Embodiments of the present disclosure enable a user-wearable infusion pump that may have a limited user interface including no display to be paired with a remote control device that can include a remote consumer electronic device such as a smartphone and/or a dedicated remote controller.
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公开(公告)号：WO2023064119A1
公开(公告)日：2023-04-20
申请号：PCT/US2022/045303
申请日：2022-09-30
申请人： AMGEN INC.
发明人： MOGHADDAM, Seyed, Reza Mirhassani , JAZAYERI, Julian , SANCHEZ, Sandra , HALILI, Edgardo , SALDANA, Cindy , VALENZUELA, Sergio, Giovanni
摘要： Apparatuses, systems and methods are provided that characterize a rear sub-assembly for an autoinjector (Al). Apparatuses, systems and methods are also provided that generate injection time (IT) models for autoinjectors (Als). Autoinjectors (Als) (e.g., mechanical Als, spring-loaded Als, etc.), components for use within Als (e.g., prefilled syringes (PFS), rear sub-assemblies (RSAs), etc.), and related methods may utilize mathematical modeling along with design for six sigma (DFSS) and design for reliability and manufacturability (D RM) to establish upstream controls that ensure injection time (IT) robustness of mechanical autoinjectors (Als). For example, break-loose and extrusion (BLE) alert limit, rear sub-assembly (RSA) area under the curve (AUG), and RSA minimum force.
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公开(公告)号：WO2023059528A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/045486
申请日：2022-10-03
摘要： A reservoir and drive assembly for a medical injector including a curved barrel having a first end and a second end positioned opposite the first end, with the curved barrel defining an interior space configured to receive a fluid, a stopper received within the interior space, with the stopper configured to move within the curved barrel to dispense fluid from the curved barrel, a curved plunger rod having a first end and a second end positioned opposite from the first end, with the curved plunger connected to the stopper, and at least one gear configured to drive the curved plunger rod and move the stopper within the curved barrel.
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