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1.发明公开PSORALEN DERIVATIVES FOR PREVENTING OR TREATING HEART FAILURE OR CARDIAC HYPERTROPHY 审中-公开用于预防或治疗心力衰竭或心脏肥大补骨脂素的衍生物
公开(公告)号：EP2866803A1
公开(公告)日：2015-05-06
申请号：EP13742406.5
申请日：2013-07-02
CPC分类号： A61K31/4433 , C07D493/04
摘要： The present invention relates to compound characterized by a general formula 1, wherein R
1 is a aryl or a heteroaryl, and - R
2 and R
3 independently of each other are hydrogen or a C
1 -C
5 alkyl, but at least one of R
2 and R
3 is not hydrogen, or together are a C
3 or C
4 alkyl forming a 5- or 6 membered ring, for use in a method for treating of heart failure, hypertension, cardiac hypertrophy or cancer.-
公开(公告)号：EP2446059B1
公开(公告)日：2015-01-07
申请号：EP10736605.6
申请日：2010-06-22
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6853 , C12Q1/6883 , C12Q2535/125 , C12Q2535/131
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3.发明公开AGONISTIC AUTOANTIBODIES TO THE ALPHA1-ADRENERGIC RECEPTOR AND THE BETA2-ADRENERGIC RECEPTOR IN ALZHEIMER'S AND VASCULAR DEMENTIA 有权激动自身抗体反对α1-抗肾上腺素能受体和β2肾上腺素受体与阿尔茨海默病和血管性痴呆
公开(公告)号：EP2742065A1
公开(公告)日：2014-06-18
申请号：EP12743103.9
申请日：2012-07-13
IPC分类号： C07K14/705 , A61P25/28
CPC分类号： C07K7/08 , A61M1/3679 , C07K14/70571 , C07K16/18 , C07K2317/75 , G01N33/564 , G01N33/566 , G01N2800/2814 , G01N2800/2821
摘要： The invention relates to means for detecting, binding, removing and/or neutralising agonistic antibodies associated with dementia, preferably Alzheimer's disease or vascular dementia.
摘要翻译： 本发明涉及一种装置，用于检测，结合，去除和/或痴呆，优选阿尔茨海默病或血管性痴呆相关的中性伊辛激动性抗体。
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4.发明授权PEPTIDES HAVING BINDING AFFINITY TO AN ANTIBODY WHICH RECOGNIZES AN EPITOPE ON AN 1 LOOP 2 OR 2 LOOP 1 OF AN ADRENORECEPTOR 有权肽连接的表位A亲和抗体IN A ALPHA1-LOOP2 OR BETA2 LOOP 1所述的肾上腺能够识别
公开(公告)号：EP2244718B1
公开(公告)日：2017-06-07
申请号：EP09702027.5
申请日：2009-01-15
申请人： Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch , Fresenius Medical Care Deutschland GmbH
IPC分类号： A61K38/00 , A61K38/08 , A61P25/28 , C07K14/705 , C07K1/22
CPC分类号： C07K17/08 , A61K38/08 , A61K38/1787 , B01J20/286 , B01J20/3251 , C07K14/723 , C07K16/28 , C07K2317/34
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5.发明公开
公开(公告)号：EP2944963A1
公开(公告)日：2015-11-18
申请号：EP14168322.7
申请日：2014-05-14
IPC分类号： G01N33/68
CPC分类号： G01N33/5038 , C12Q1/04 , G01N33/58 , G01N33/6848 , G01N2458/15 , G01N2570/00 , H01J49/0036
摘要： The present invention relates to a method for preparation of labeled metabolic products, comprising the steps (a) providing a biological sample in vitro, (b) contacting the biological sample with a labeling buffer comprising a labeled substrate, wherein the substrate comprises at least one carbon atom and represents an educt or intermediate of a metabolic process of the biological sample and wherein the label is a stable isotope, (c) washing the biological sample using a wash-buffer, wherein said wash-buffer comprises a carbon resource such that the biological sample is precluded from carbon deficiency during said washing, wherein said carbon resource comprises the substrate according to step b), wherein said substrate in the wash-buffer may be labeled or unlabeled, (d) quenching the biological sample such that metabolic processes within the biological sample are slowed down or stopped and (e) extracting the labeled metabolic product from the biological sample. The present invention further refers to methods for quantification of labeled metabolic products from biological sample.
摘要翻译： 本发明涉及一种制备标记的代谢产物的方法，包括步骤（a）在体外提供生物样品，（b）使生物样品与包含标记的底物的标记缓冲液接触，其中所述底物包含至少一种 碳原子并且代表生物样品的代谢过程的衍生物或中间体，并且其中所述标记是稳定同位素，（c）使用洗涤缓冲液洗涤所述生物样品，其中所述洗涤缓冲液包含碳资源，使得 在所述洗涤期间，生物样品不含碳缺乏，其中所述碳源包括根据步骤b）的底物，其中洗涤缓冲液中的所述底物可以标记或未标记，（d）猝灭生物样品，使得在 生物样品减慢或停止，（e）从生物样品中提取标记的代谢产物。 本发明还涉及从生物样品中定量标记的代谢产物的方法。
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6.发明公开GPNMB/OSTEOACTIVIN AS A BIOMARKER AND DRUG TARGET IN CARDIAC DISEASES 审中-公开GPNMB / OSTEOACTIVIN AS心脏疾病生物标志物和目标分子
公开(公告)号：EP2646574A1
公开(公告)日：2013-10-09
申请号：EP11791277.4
申请日：2011-12-01
发明人： BADER, Michael , ÖZCELIK, Cemil , MÜHLSTEDT, Silke
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N2800/32
摘要： The present invention relates to the gene Gpnmb and its use as a genetic marker in the incidence of cardiovascular conditions and cardiac diseases, such as complications derived from myocardial infarction. Gpnmb provides a valuable tool both for diagnostic as well as therapeutic approaches, in order to treat or prevent cardiovascular conditions and cardiac diseases, in particular complications derived from myocardial infarction.
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7.发明公开
公开(公告)号：EP2645119A1
公开(公告)日：2013-10-02
申请号：EP13161942.1
申请日：2013-04-02
发明人： Niendorf, Thoralf , Hezel, Fabian , Klix, Sabrina
IPC分类号： G01R33/561
CPC分类号： G01R33/56509 , G01R33/5611 , G01R33/5615 , G01R33/5617 , G01R33/5676
摘要： Die Erfindung betrifft ein Magnetresonanztomographie-Verfahren, wobei nach einer Grundanregung und einer Serie von Hochfrequenz-Refokussierungspulsen nach dem Spin-Echo Prinzip zwei Echogruppen entstehen, wobei beide Echogruppen unabhängig voneinander phasenkodiert werden, und wobei die Rekonstruktion für beide Echogruppen unabhängig voneinander erfolgt.
摘要翻译： 该方法包括通过根据自旋回波原理的两个回波组的一系列激发和射频重聚焦脉冲形成基座，其中一个回波组用于接收用于自身的参考数据集或训练数据集 校准和另一个回波组通过下采样记录。 通过沿着相位编码方向实现独立梯度，独立地对回波组进行相位编码。 回波组被独立重建。
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公开(公告)号：EP2446059A2
公开(公告)日：2012-05-02
申请号：EP10736605.6
申请日：2010-06-22
发明人： GOTTHARDT, Michael , GREASER, Lewis , GUO, Wei
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6853 , C12Q1/6883 , C12Q2535/125 , C12Q2535/131
摘要： The invention refers to polynucleotides selected from the group consisting of a) polynucleotides encoding for the polypeptide RBM20 comprising a P638L mutation for a human polypeptide RBM20, or a P641L mutation for a rat polypeptide RBM20, b) polynucleotides with a reverse complementary sequence of the polynucleotide of a) above, and c) polynucleotides with an identity at least 50 % to a polynucleotide of a) or b) above.
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9.发明公开
公开(公告)号：EP2678704A1
公开(公告)日：2014-01-01
申请号：EP11708427.7
申请日：2011-02-25
IPC分类号： G01R33/567 , A61B5/0265 , A61B5/0456
CPC分类号： G01R33/5635 , A61B5/0265 , A61B5/0402 , A61B5/055 , A61B5/7289 , G01R33/5673
摘要： A magnetic field apparatus comprises a generator for generating a magnetic field of the magnetic field apparatus and a sensor for measuring the interaction between electrical charge carriers in an object and the magnetic field, wherein the electrical charge carriers and the magnetic field are in relative motion to each other. The magnetic field apparatus may in particular be an MRI apparatus and the sensor may use the magnetohydrodynamic effect for deriving a cardiac trigger signal at any target area positioned off-centre to the heart.
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10.发明公开MAGNETIC RESONANCE TOMOGRAPHY (MRT) APPARATUS AND METHOD OF OPERATING A MAGNETIC RESONANCE (MR) APPARATUS 审中-公开磁断层扫描（MRI）和方法进行操作MR装置
公开(公告)号：EP2677926A2
公开(公告)日：2014-01-01
申请号：EP12710456.0
申请日：2012-02-27
IPC分类号： A61B5/055 , G01R33/567
CPC分类号： A61B5/055 , A61B5/0456 , A61B5/0816 , A61B5/14551 , G01R33/5673 , G01R33/5676
摘要： A magnetic resonance tomography (MRT) apparatus (1) for the examination of a body (14) comprises parameter acquisition devices (13) for the acquisition of cardiovascular parameters of the body (14) and a control device (15) in communication with the parameter acquisition devices (13) for synchronizing the imaging, wherein the control device (15) is adapted to analyse the data of at least two parameter acquisition devices (13) and to output a control signal based on the analysis.
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