专利检索 ap:("Max-Delbrück-Centrum für Molekulare Medizin Berlin-Buch") AND inv:"KLUSSMANN, Enno" 第 1 页

1.

发明公开
PSORALEN DERIVATIVES FOR PREVENTING OR TREATING HEART FAILURE OR CARDIAC HYPERTROPHY 审中-公开
标题翻译：用于预防或治疗心力衰竭或心脏肥大补骨脂素的衍生物

公开(公告)号：EP2866803A1

公开(公告)日：2015-05-06

申请号：EP13742406.5

申请日：2013-07-02

申请人： Max-Delbrück-Centrum für Molekulare Medizin Berlin-Buch

发明人： KLUSSMANN, Enno , TRÖGER, Jessica , ROSENTHAL, Walter

IPC分类号： A61K31/35 , A61P9/00 , A61P9/04 , A61P9/12

CPC分类号： A61K31/4433 , C07D493/04

摘要： The present invention relates to compound characterized by a general formula 1, wherein R
1 is a aryl or a heteroaryl, and - R
2 and R
3 independently of each other are hydrogen or a C
1 -C
5 alkyl, but at least one of R
2 and R
3 is not hydrogen, or together are a C
3 or C
4 alkyl forming a 5- or 6 membered ring, for use in a method for treating of heart failure, hypertension, cardiac hypertrophy or cancer.

2.

发明公开
N-ARYLAMINOMETHYLENE BENZOTHIOPHENONES FOR TREATMENT OF CARDIOVASCULAR DISEASE 审中-公开
标题翻译：的N- ARYLAMINOMETHYLEN-BENZOTHIOPHENONE用于治疗心血管疾病的治疗

公开(公告)号：EP2665475A2

公开(公告)日：2013-11-27

申请号：EP12701335.7

申请日：2012-01-18

申请人： Max-Delbrück-Centrum für Molekulare Medizin Berlin-Buch , Forschungsverbund Berlin E.V.

发明人： KLUSSMANN, Enno , ROSENTHAL, Walter , MILIC, Jelena , BERGMANN, Martin W.

IPC分类号： A61K31/135

CPC分类号： C07D417/12 , A61K31/135 , A61K31/343 , A61K31/381 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/4709 , C07D333/64 , C07D403/12 , C07D409/12 , C07D413/12

摘要： The invention relates to N-arylaminomethylenebenzothiophenones of General Formula (I) for use as a drug for the treatment of cardiovascular diseases, wherein E is S, O, or CH
2 , D is CH or NH, and Ar is a phenyl or naphtyl moiety substituted by an electron-withdrawing group, an unsubstituted heteroaryl residue, or a heteroaryl residue substituted by alkyl or an electron-withdrawing group.