公开(公告)号：EP4353929A1

公开(公告)日：2024-04-17

申请号：EP22201006.8

申请日：2022-10-12

申请人： Gatemaster Ltd

发明人： NAPTHINE, Simon Garth

IPC分类号： E05B65/00 ,  E05C3/04 ,  E05C7/04 ,  E06B11/02

CPC分类号： E05B65/0007 ,  E06B11/02 ,  E05B63/18 ,  E05C7/04 ,  E05C3/145 ,  E05B15/1635

摘要： A latching gate fastener is provided for fastening a double gate, the gate fastener comprising a pivotable body that is fixable to a first gate; and at least one ramp for contacting a second gate, wherein the pivotable body comprises at least one recess for receiving a gate rail on the second gate. Also provided is a gate having said fastener and a method of securing a double gate using the fastener.

公开(公告)号：EP4253412A2

公开(公告)日：2023-10-04

申请号：EP23173594.5

申请日：2016-12-16

申请人： The Walter and Eliza Hall Institute of Medical Research

发明人： HUNTINGTON, Nicholas D. ,  NICHOLSON, Sandra E.

IPC分类号： C07K16/22

摘要： The present invention relates to therapeutic and prophylactic methods based on inhibition of CIS in NK cells. In particular, the present invention relates to treating or preventing a NK-responsive condition by administering to a subject a CIS inhibitor, or administering CIS-inhibited NK cells. The invention further relates to methods for identifying a CIS inhibitor, and for determining a likelihood of cancer response to treatment with CIS inhibition

公开(公告)号：EP3626915B1

公开(公告)日：2023-07-12

申请号：EP19199033.2

申请日：2019-09-23

发明人： NAPTHINE, Simon Garth ,  MATTHEWS, Mark

IPC分类号： E05B9/00 ,  E05B9/02 ,  E05B63/00 ,  E05B63/04

公开(公告)号：EP4126959A2

公开(公告)日：2023-02-08

申请号：EP21780751.0

申请日：2021-03-31

申请人： Fred Hutchinson Cancer Center

发明人： TURTLE, Cameron, J. ,  WALTER, Roland, B. ,  LASZLO, George, S. ,  FIORENZA, Salvatore

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K35/17 ,  A61P35/00

公开(公告)号：EP4104841A1

公开(公告)日：2022-12-21

申请号：EP22179362.3

申请日：2017-12-11

申请人： ONK Therapeutics Limited

发明人： O'DWYER, Michael Eamon Peter

IPC分类号： A61K35/15 ,  A61K39/00 ,  A61P35/00

摘要： Provided herein are engineered natural killer cells that have been modified to express chimeric antigen receptors (CARs). The cells optionally contain other modifications that improve tumor specific cytotoxicity and homing to tumor sites. Also contemplated are methods for using the engineered natural killer cells to treat patients with cancer.

公开(公告)号：EP3957227A1

公开(公告)日：2022-02-23

申请号：EP21152733.8

申请日：2021-01-21

申请人： Awadu Satoshi

发明人： SATOSHI, Awadu

IPC分类号： A61B1/00 ,  A61B1/005 ,  A61B1/233 ,  A61B1/32

摘要： A flexible endoscope insertion method includes: rotating a hollow organ by changing the body position to semilateral position or lateral position for observing the lateral wall of the lumen; turning the tip of the flexible endoscope to the lateral wall of the lumen by rotating the flexible endoscope in the counter direction of the lumen; and retracting the organ with the flexible endoscope itself by rotating the flexible endoscope in the counter direction of the lumen. In other embodiments, the method includes: rotating a body cavity by changing the body position to the appropriate position for observing the lateral side of the organ; turning the tip of the flexible endoscope to the lateral side of the organ by rotating the flexible endoscope in the direction of the lateral side of the organ; and retracting the organ with the flexible endoscope itself by rotating the flexible endoscope in the direction of the lateral side of the organ. Methods of visualizing and accessing a lumen interior of the body are provided using the endoscope.

公开(公告)号：EP3895712A1

公开(公告)日：2021-10-20

申请号：EP21160170.3

申请日：2017-12-11

申请人： ONK Therapeutics Limited

发明人： O'DWYER, Michael Eamon Peter

IPC分类号： A61K35/15 ,  A61K39/00 ,  A61P35/00

摘要： Provided herein are engineered natural killer cells that have been modified to express chimeric antigen receptors (CARs). The cells optionally contain other modifications that improve tumor specific cytotoxicity and homing to tumor sites. Also contemplated are methods for using the engineered natural killer cells to treat patients with cancer.

公开(公告)号：EP3658192B1

公开(公告)日：2021-04-28

申请号：EP18833113.6

申请日：2018-11-29

发明人： HOBSON, Adrian D. ,  MCPHERSON, Michael J. ,  WAEGELL, Wendy ,  GOESS, Christian ,  HERNANDEZ, Axel, Jr. ,  WANG, Lu ,  WANG, Lu ,  MARVIN, Christopher C. ,  SANTORA, Ling C.

IPC分类号： A61K47/68 ,  A61K38/19 ,  C07K16/24 ,  A61P1/00 ,  A61P19/02

公开(公告)号：EP3800999A1

公开(公告)日：2021-04-14

申请号：EP19815783.6

申请日：2019-05-31

申请人： Biogen MA Inc.

发明人： FERRANT-ORGETTAS, Janine, Lisa ,  PEPINSKY, Robert, Blake ,  CAHIR-MCFARLAND, Ellen, Duggan ,  D'LIMA, Nadia, Giselle ,  ARNDT, Joseph, Walter ,  HANF, Karl, John Mortley ,  CAMERON, Thomas, Owen ,  STARK, Ellen, Garber

IPC分类号： A01H6/82

公开(公告)号：EP3626915A1

公开(公告)日：2020-03-25

申请号：EP19199033.2

申请日：2019-09-23

申请人： Gatemaster Ltd

发明人： NAPTHINE, Simon Garth ,  MATTHEWS, Mark

IPC分类号： E05B9/00 ,  E05B9/02 ,  E05B63/00 ,  E05B63/04

摘要： A lock comprising a housing, at least one lock mechanism in the housing and at least two panels in the housing, wherein at least one panel is removably insertable into the housing and at least one panel comprises a lock interface to allow access to the lock mechanism.