公开(公告)号：EP2695950A1

公开(公告)日：2014-02-12

申请号：EP12180179.9

申请日：2012-08-10

申请人： Blackfield AG

发明人： Thomas, Roman ,  Malchers, Florian

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/6863 ,  G01N2333/50 ,  G01N2333/71

摘要： The present invention relates to a method for predicting the responsiveness of a mammalian tumor cell or cancer cell to an inhibitor of a fibroblast growth factor receptor (FGFR). Also a method for predicting the responsiveness of an individual to an inhibitor of a fibroblast growth factor receptor (FGFR) is provided. These methods involve the evaluation of the status of FGFR and the status of c-myc, whereby said status of FGFR and of c-myc is indicative for the responsiveness to the inhibitor. The status of FGFR may be its amplifcation status or its expression level and the status of c-myc may be its expression level, like an intermediate or high expression level of c-myc. Furthermore, a kit useful for carrying out the methods described herein as well as an oligo- or polynucleotide and/or antibodies capable of detecting the expression level or gene amplification status of FGFR or the expression level of c-myc for predicting the responsiveness to the inhibitor are provided.

摘要翻译： 本发明涉及一种预测哺乳动物肿瘤细胞或癌细胞对成纤维细胞生长因子受体（FGFR）抑制剂的反应性的方法。 还提供了预测个体对成纤维细胞生长因子受体（FGFR）的抑制剂的反应性的方法。 这些方法包括评估FGFR的状态和c-myc的状态，由此所述FGFR和c-myc的状态指示对抑制剂的反应。 FGFR的状态可能是其扩增状态或其表达水平，c-myc的状态可能是其表达水平，如c-myc的中等或高表达水平。 此外，可用于实施本文所述方法的试剂盒以及能够检测FGFR的表达水平或基因扩增状态的寡核苷酸和/或抗体或c-myc的表达水平用于预测对 提供抑制剂。