公开(公告)号：EP0254031A2

公开(公告)日：1988-01-27

申请号：EP87108718.5

申请日：1987-06-16

申请人： Consolidated Controls Corporation

发明人： Reinicke, Robert Henry ,  Yamoto, Lance Manabu

IPC分类号： A61M5/14

CPC分类号： A61M5/14276 ,  A61M1/0098 ,  A61M5/141 ,  A61M5/165 ,  A61M5/16804 ,  A61M5/16877 ,  A61M2005/1652 ,  A61M2205/0244 ,  F15C5/00 ,  Y10S128/12

摘要： An implantable positive pressure medication infusion device is provided which is programmable over a wide dynamic range and yet the maximum flow of medication into the body, in the event the inlet valve of the device leaks or fails in the valve open position, is limited to a safe value which is much lower than the maximum programmable infusion rate of the device. An auxiliary flow restrictor is also provided which bypasses the programmable pumping unit and assures a minimum flow of medication into the body in the event of failure of the programmable pumping unit or its electronic drive. An arrangement is also provided for detecting catheter clogging or failure of the programmable pumping unit in either a positive or negative pressure device.

摘要翻译： 提供了一种可植入的正压药物输注装置，其可在宽的动态范围内编程，而在药物进入体内的最大流量在装置的入口阀在阀打开位置泄漏或失效的情况下被限制为 安全值远远低于设备的最大可编程输入速率。 还提供辅助流量限制器，其绕过可编程泵送单元，并且在可编程泵送单元或其电子驱动器发生故障的情况下确保最小的药物流入体内。 还提供了用于检测导管堵塞或可编程泵送单元在正或负压装置中的故障的布置。

公开(公告)号：EP0112585B1

公开(公告)日：1987-04-29

申请号：EP83113157.8

申请日：1983-12-27

申请人： Consolidated Controls Corporation

发明人： Reinicke, Robert H.

IPC分类号： A61M5/14

CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M2005/14264 ,  G05D7/0676

公开(公告)号：EP0189940A3

公开(公告)日：1988-05-25

申请号：EP86101307

申请日：1986-01-31

申请人： Consolidated Controls Corporation

发明人： Reinicke, Robert H.

IPC分类号： A61M05/14

CPC分类号： A61M5/14276 ,  A61M5/141 ,  A61M5/14586 ,  A61M5/16804 ,  A61M5/16877 ,  A61M2205/0244 ,  Y10S128/12

摘要： An integral fluid filter and capillary restrictor unit (40), or alternatively an integral fluid filter and multiple orifice restrictor unit, is resiliently positioned in a manifold body (22) which is edge mounted to a flat cylindrical assembly which contains the medication reservoir (18) and pressure stabilizing chamber (20) to provide a completely self- contained implantable unit which is thin, small and lightweight and yet needs to be refilled only as often as the much larger stainless steel capillary tube devices with bellows type reservoirs now on the market.

摘要翻译： 整体式流体过滤器和毛细管限制器单元或者一体式流体过滤器和多个节流孔限制器单元被弹性地定位在歧管主体中，该歧管主体边缘安装到平坦的圆柱形组件，该圆柱形组件包含药物储存器和压力稳定室以提供完全 独立的可植入单元，体积小，重量轻且重量轻，但需要再次填充，就像现在市面上有波纹管式储存器的大型不锈钢毛细管装置一样。

公开(公告)号：EP0254031A3

公开(公告)日：1990-02-14

申请号：EP87108718.5

申请日：1987-06-16

申请人： Consolidated Controls Corporation

发明人： Reinicke, Robert Henry ,  Yamoto, Lance Manabu

IPC分类号： A61M5/14

CPC分类号： A61M5/14276 ,  A61M1/0098 ,  A61M5/141 ,  A61M5/165 ,  A61M5/16804 ,  A61M5/16877 ,  A61M2005/1652 ,  A61M2205/0244 ,  F15C5/00 ,  Y10S128/12

摘要： An implantable positive pressure medication infusion device is provided which is programmable over a wide dynamic range and yet the maximum flow of medication into the body, in the event the inlet valve of the device leaks or fails in the valve open position, is limited to a safe value which is much lower than the maximum programmable infusion rate of the device. An auxiliary flow restrictor is also provided which bypasses the programmable pumping unit and assures a minimum flow of medication into the body in the event of failure of the programmable pumping unit or its electronic drive. An arrangement is also provided for detecting catheter clogging or failure of the programmable pumping unit in either a positive or negative pressure device.

摘要翻译： 提供了一种可植入的正压药物输注装置，其可在宽的动态范围内编程，而在药物进入体内的最大流量在装置的入口阀在阀打开位置泄漏或失效的情况下被限制为 安全值远远低于设备的最大可编程输入速率。 还提供辅助流量限制器，其绕过可编程泵送单元，并且在可编程泵送单元或其电子驱动器发生故障的情况下确保最小的药物流入体内。 还提供了用于检测导管堵塞或可编程泵送单元在正或负压装置中的故障的布置。

公开(公告)号：EP0142866A3

公开(公告)日：1986-12-10

申请号：EP84114090

申请日：1984-11-22

申请人： Consolidated Controls Corporation

发明人： Reinicke, Robert H.

IPC分类号： A61M05/14

CPC分类号： A61M5/14276 ,  A61M5/14593 ,  A61M5/16809 ,  A61M2039/0054 ,  F15C5/00 ,  Y10S128/12

摘要： An implantable medication infusion unit wherein a generally cylindrical manifold (20) is employed having a shallow recess (28) on one face thereof. A flexible diaphragm (26) is positioned to form with the face of said manifold a medication reservoir (30). A circular cover member (24) is positioned over the diaphragm to form with said diaphragm a pressure stabilizing chamber (32) within which is positioned a two-phase fluid for maintaining a constant pressure on said diaphragm. A permanent magnet (42) is positioned at the center of said diaphragm and is movable therewith. A Hall effect transducer (34) positioned on said manifold opposite said permanent magnet is employed continuously to measure the position of said diaphragm and provide an indication of the amount of medication in said reservoir (30). A method of filling and sealing the pressure stabilizing chamber (32) which ensures that a small bubble of two-phase fluid is present in said chamber at all times. An inlet filter (100) may be positioned between the medication reservoir (30) and an inlet check valve (102) to act as a bubble trap during the intake stroke of a pulsatile pumping unit also mounted in the manifold.

公开(公告)号：EP0142866A2

公开(公告)日：1985-05-29

申请号：EP84114090.8

申请日：1984-11-22

申请人： Consolidated Controls Corporation

发明人： Reinicke, Robert H.

IPC分类号： A61M5/14

CPC分类号： A61M5/14276 ,  A61M5/14593 ,  A61M5/16809 ,  A61M2039/0054 ,  F15C5/00 ,  Y10S128/12

摘要： An implantable medication infusion unit wherein a generally cylindrical manifold (20) is employed having a shallow recess (28) on one face thereof. A flexible diaphragm (26) is positioned to form with the face of said manifold a medication reservoir (30). A circular cover member (24) is positioned over the diaphragm to form with said diaphragm a pressure stabilizing chamber (32) within which is positioned a two-phase fluid for maintaining a constant pressure on said diaphragm. A permanent magnet (42) is positioned at the center of said diaphragm and is movable therewith. A Hall effect transducer (34) positioned on said manifold opposite said permanent magnet is employed continuously to measure the position of said diaphragm and provide an indication of the amount of medication in said reservoir (30).
A method of filling and sealing the pressure stabilizing chamber (32) which ensures that a small bubble of two-phase fluid is present in said chamber at all times.
An inlet filter (100) may be positioned between the medication reservoir (30) and an inlet check valve (102) to act as a bubble trap during the intake stroke of a pulsatile pumping unit also mounted in the manifold.

公开(公告)号：EP0112585A1

公开(公告)日：1984-07-04

申请号：EP83113157.8

申请日：1983-12-27

申请人： Consolidated Controls Corporation

发明人： Reinicke, Robert H.

IPC分类号： A61M5/14

CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M2005/14264 ,  G05D7/0676

摘要： A precision medication dispensing system comprising an implantable device (10). The device includes a medication reservoir (12), a pulsatile pump (24) and an absolute pressure transducer (70). The pumping pressure wave developed in the pumping chamber (60) is measured by the absolute pressure transducer (70) whose output is used to adjust the pulsing rate of the solenoid operated pump (24) so that the programmed time averaged rate of infusion of medication into the body is precisely maintained throughout all operating temperature and pressure conditions.

摘要翻译： 一种精密药物分配系统，包括可植入装置（10）。 该装置包括药物贮存器（12），脉动泵（24）和绝对压力传感器（70）。 在泵送室（60）中产生的泵送压力波由绝对压力传感器（70）测量，绝对压力传感器（70）的输出用于调节电磁操作泵（24）的脉冲速率，使得程序输入药物的平均速率 在整个工作温度和压力条件下精确地保持身体。

公开(公告)号：EP0189940A2

公开(公告)日：1986-08-06

申请号：EP86101307.6

申请日：1986-01-31

申请人： Consolidated Controls Corporation

发明人： Reinicke, Robert H.

IPC分类号： A61M5/14

CPC分类号： A61M5/14276 ,  A61M5/141 ,  A61M5/14586 ,  A61M5/16804 ,  A61M5/16877 ,  A61M2205/0244 ,  Y10S128/12

摘要： An integral fluid filter and capillary restrictor unit (40), or alternatively an integral fluid filter and multiple orifice restrictor unit, is resiliently positioned in a manifold body (22) which is edge mounted to a flat cylindrical assembly which contains the medication reservoir (18) and pressure stabilizing chamber (20) to provide a completely self- contained implantable unit which is thin, small and lightweight and yet needs to be refilled only as often as the much larger stainless steel capillary tube devices with bellows type reservoirs now on the market.

摘要翻译： 整体式流体过滤器和毛细管限制器单元或者一体式流体过滤器和多个节流孔限制器单元被弹性地定位在歧管主体中，该歧管主体边缘安装到平坦的圆柱形组件，该圆柱形组件包含药物储存器和压力稳定室以提供完全 独立的可植入单元，体积小，重量轻且重量轻，但需要再次填充，就像现在市面上有波纹管式储存器的大型不锈钢毛细管装置一样。