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公开(公告)号：EP4393919A1
公开(公告)日：2024-07-03
申请号：EP22307048.3
申请日：2022-12-27
IPC分类号： C07D413/10 , C07D413/14 , C07D417/10 , C07D471/02 , C07D491/02 , A61K31/438 , A61P35/00 , A61K31/421 , A61K31/427 , A61K31/437
CPC分类号： C07D413/10 , C07D417/10 , C07D471/02 , C07D413/14 , C07D491/02 , A61P35/00
摘要： Disclosed are compounds, compositions and methods for treating disease, syndromes, conditions and disorders that are affected by the modulation of LSD1. Such compounds are represented by formula (I) wherein the variables are defined herein.
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公开(公告)号：EP4333982A1
公开(公告)日：2024-03-13
申请号：EP22731281.6
申请日：2022-05-06
发明人： RAY, Peter , BRADLEY, Anthony , RICHARDS, Simon , SANTOS, Catarina , BESNARD, Jeremy , MENEYROL, Jérôme , SUCHAUD, Virginie
IPC分类号： A61P31/18 , A61P35/00 , A61P37/00 , C07D471/04 , C07D471/08 , C07D487/08 , C07D491/04 , C07D498/04 , A61K31/437
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公开(公告)号：EP4288966A1
公开(公告)日：2023-12-13
申请号：EP22709768.0
申请日：2022-02-08
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公开(公告)号：EP4334316A1
公开(公告)日：2024-03-13
申请号：EP22731282.4
申请日：2022-05-06
发明人： RAY, Peter , BRADLEY, Anthony , RICHARDS, Simon , SANTOS, Catarina , BESNARD, Jeremy , MENEYROL, Jérôme , SUCHAUD, Virginie
IPC分类号： C07D471/04 , A61K31/437 , A61P31/18 , A61P35/00 , A61P37/00
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公开(公告)号：EP4269402A1
公开(公告)日：2023-11-01
申请号：EP21908644.4
申请日：2021-08-27
IPC分类号： C07D401/14 , C07D401/00 , A61K31/506 , A61K31/505 , A61K31/495 , C07D471/04 , C07D413/14 , C07D417/14 , A61P35/00
摘要： An aromatic heterocyclic compound, a pharmaceutical composition and use thereof. Specifically disclosed are a compound as shown in formula I, a stereoisomer thereof, a diastereomer thereof, or a pharmaceutically acceptable salt of any one of the foregoing, or a crystal form or solvate of any one of the foregoing. The aromatic heterocyclic compound has a novel structure, good CDK7 inhibitory activity, and good selectivity.
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公开(公告)号：EP4247492A1
公开(公告)日：2023-09-27
申请号：EP21836594.8
申请日：2021-11-23
发明人： RAY, Peter , EVANS, David , BRADLEY, Anthony , RADOUX, Chris , RICHARDS, Simon , SANTOS, Catarina , BESNARD, Jeremy , COOKE, Andrew, John , GOMEZ, Sylvie Félicité , CAZAUX-LEROU, Lorène, Nathalie, Sabine , PINTO, Marta , PUCCI, Sabrina , BLANGER, Claire, Christiane, Ginette
IPC分类号： A61P29/02 , A61K31/4353 , A61K31/4709 , A61K31/519 , A61P35/00 , A61P37/00 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14
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8.发明公开
公开(公告)号：EP4269403A1
公开(公告)日：2023-11-01
申请号：EP21908645.1
申请日：2021-08-27
IPC分类号： C07D401/14 , C07D401/00 , A61K31/506 , A61K31/505 , A61K31/495 , C07D471/04 , A61P35/00
摘要： An aromatic heterocyclic compound, and a pharmaceutical composition and an application thereof. Specifically disclosed are a compound as represented by formula I-A, a stereoisomer thereof, a diastereoisomer thereof, or a pharmaceutically acceptable salt of any one of the described substances, or a crystalline form or a solvate of any one of the described substances. The aromatic heterocyclic compound is novel in structure, and has good CDK7 inhibitory activity and good selectivity.
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公开(公告)号：EP4238097A2
公开(公告)日：2023-09-06
申请号：EP21884122.9
申请日：2021-10-29
IPC分类号： G16B40/00 , G06F16/35 , G06F40/295 , G16C20/70
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公开(公告)号：EP4105935A1
公开(公告)日：2022-12-21
申请号：EP22162348.1
申请日：2010-11-22
摘要： A method for computational drug design using an evolutionary algorithm, comprises evaluating virtual molecules according to vector distance (VD) to at least one achievement objective that defines a desired ideal molecule. In one method the invention comprises defining a set of n achievement objectives (O A 1-n ), where n is at least one; defining a population (P G=0 ) of at least one molecule; selecting an initial population (P parent ) of at least one molecule (I 1 -I n ) from the population (P G=0 ); and evaluating members (I 1 -I n ) of the initial population (P parent ) against at least one of the n achievement objectives (O A 1-x ), where x is from 1 to n.
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