公开(公告)号：EP4420734A3

公开(公告)日：2024-11-06

申请号：EP24172770.0

申请日：2016-02-12

申请人： Institut National de la Santé et de la Recherche Médicale ,  Université Paris Cité

发明人： CHARLES, Nicolas ,  PELLEFIGUES, Christophe

IPC分类号： A61K31/403 ,  A61P29/00 ,  A61K45/06 ,  A61P37/02 ,  A61P43/00

摘要： The present invention concerns a PTGDR-1 antagonist, a PTGDR-2 antagonist, a dual PTGDR-1/PTGDR-1 antagonist, or a combination of PTGDR-1 antagonist and PTGDR-2 antagonist, and pharmaceutical compositions containing them, for use for preventing and/or treating SLE.

公开(公告)号：EP4452275A1

公开(公告)日：2024-10-30

申请号：EP22840667.4

申请日：2022-12-20

申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Sorbonne Université ,  Université Paris Cité ,  APHP (Assistance Publique - Hôpitaux de Paris)

发明人： REBOUISSOU, Sandra ,  MOREL-RIBEIRO, Pierre ,  NAULT, Jean-Charles ,  HIRSCH, Théo ,  ZUCMAN-ROSSI, Jessica ,  PILET, Jill

IPC分类号： A61K31/5377 ,  A61K33/243 ,  A61P35/00

公开(公告)号：EP4449977A1

公开(公告)日：2024-10-23

申请号：EP23169081.9

申请日：2023-04-20

申请人： Université d'Aix Marseille ,  Institut National de la Santé et de la Recherche Médicale

发明人： JIRSA, Viktor ,  HASHEMI, Meysam ,  ARBABYAZD, Lucas ,  WILLIAMSON, Adam

IPC分类号： A61B5/00 ,  A61N1/04

摘要： The invention relates to a method for inferring a change in a whole-brain network in a brain of a mammal. The method comprises the steps of providing a computerized platform modelling various regions of a mammal brain and connectivity between these regions; providing three-dimensional anatomical structural imaging data of the brain of the mammal; providing a parametric mathematical neural model describing an evolution of the neural field in a brain of a mammal; providing magnetic resonance imaging time-series data of the brain; fitting the model with the magnetic resonance imaging time-series acquired; estimating the parameters of the model; inverting the model; and inferring the change in the whole-brain network in the mammal's brain.

公开(公告)号：EP4414002A3

公开(公告)日：2024-10-16

申请号：EP24178498.2

申请日：2020-07-17

申请人： Institut National de la Santé et de la Recherche Médicale ,  Fondation Imagine ,  APHP (Assistance Publique - Hôpitaux de Paris) ,  Université Paris Cité ,  Université Toulouse III - Paul Sabatier

发明人： LAGRESLE-PEYROU, Chantal ,  OLICHON, Aurélien ,  SADEK-ROCK, Hanem ,  ANDRE, Isabelle ,  CAVAZZANA, Marina

IPC分类号： A61K38/17 ,  A61K31/713 ,  A61P35/02 ,  C07K14/00 ,  A61K48/00

摘要： The inventors have identified an autosomal dominant (AD) missense mutation in the RAC2 gene (coding for Ras-related C3 botulinum toxin substrate 2 (RAC2)) in three Severe combined immunodeficiencies (SCID) patients whose clinical presentation overlaps with the RD SCID form but who lack AK2 mutations and deafness. Using biochemical and in vitro differentiation assays, the inventors demonstrated that the RAC2 mutation was closely related to an impairment in cell differentiation capacity and defects in cellular and mitochondrial networks. Taken as a whole, the data demonstrate that a dominant gain-of-function (GOF) mutation in the RAC2 protein's GDP/GTP binding site inhibits HSPC differentiation and leads to a severe AD form of SCID with a clinical presentation of RD. Accordingly, the results prompt to consider that introduction of the identified RAC2 mutein in the hematopoietic lineage would be suitable for inducing full ablation of hematopoiesis.

公开(公告)号：EP4440569A1

公开(公告)日：2024-10-09

申请号：EP22823465.4

申请日：2022-11-30

申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Centre National de la Recherche Scientifique ,  Université Côte d'Azur ,  Centre Hospitalier Régional ,  Association Française contre les Myopathies (A.F.M.)

发明人： PAQUIS-FLUCKLINGER, Véronique ,  AZOULAY, Stéphane ,  D'ELIA, Marc-Alexandre ,  ROPERT, Baptiste

IPC分类号： A61K31/345 ,  A61P25/28 ,  A61P9/00 ,  A61P21/00

CPC分类号： A61K31/345 ,  A61P25/28 ,  A61P9/00 ,  A61P21/00

公开(公告)号：EP4433504A1

公开(公告)日：2024-09-25

申请号：EP22818329.9

申请日：2022-11-16

申请人： Institut National de la Santé et de la Recherche Médicale ,  Assistance Publique des Hopitaux de Paris ,  Baylor Research Institute ,  Université Paris Est Créteil Val de Marne

发明人： LEVY, Yves ,  ZURAWSKI, Gérard ,  ZURAWSKI, Sandra ,  CENTLIVRE, Mireille ,  LACABARATZ, Christine ,  CARDINAUD, Sylvain ,  SURENAUD, Mathieu

IPC分类号： C07K16/28 ,  C07K14/165 ,  A61K39/12

CPC分类号： C07K16/2878 ,  C07K14/165 ,  C07K2319/3320130101 ,  C07K2319/7420130101 ,  C12N2770/2002220130101 ,  C12N2770/2003420130101 ,  A61K39/12

公开(公告)号：EP4426325A1

公开(公告)日：2024-09-11

申请号：EP22792791.0

申请日：2022-09-16

申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Université de Rouen ,  Targedys

发明人： FETISSOV, Serguei ,  NICOL, Marion ,  PICOLO, Clémentine ,  LAMBERT, Grégory

IPC分类号： A61K35/747 ,  A61K35/745 ,  A61P25/24 ,  A61P25/22 ,  A61K38/16

CPC分类号： A61K35/747 ,  A61K35/745 ,  A61P25/24 ,  A61P25/22 ,  A61K38/164

公开(公告)号：EP4426277A1

公开(公告)日：2024-09-11

申请号：EP22813186.8

申请日：2022-10-31

申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Centre National de la Recherche Scientifique ,  Université d'Aix-Marseille

发明人： NAQUET, Philippe ,  GALLAND, Franck ,  MILLET, Virginie

IPC分类号： A61K31/145 ,  A61K31/197 ,  A61K45/06 ,  A61P1/00 ,  A61P29/00

CPC分类号： A61K45/06 ,  A61K31/197 ,  A61K31/145 ,  A61P1/00 ,  A61P29/00

公开(公告)号：EP4424711A2

公开(公告)日：2024-09-04

申请号：EP24184659.1

申请日：2021-05-19

申请人： Institut Curie ,  Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Centre National de la Recherche Scientifique

发明人： RODRIGUEZ, Raphaël ,  MULLER, Sebastian ,  SOLIER, Stéphanie ,  WATSON, Sarah

IPC分类号： C07K16/28

CPC分类号： A61K33/26 ,  C07K16/2884 ,  A61P29/00 ,  A61P37/02 ,  A61P39/04 ,  C07K2317/7620130101 ,  C07K2317/2420130101 ,  G01N33/53 ,  G01N2333/7058520130101 ,  G01N2800/705720130101 ,  G01N2800/5020130101 ,  G01N2333/16520130101

摘要： The invention relates to methods and pharmaceutical compositions for the treatment of Cytokine Release Syndrome (CRS). The invention also relates to methods for the diagnosis of patients suffering from Cytokine Release Syndrome.The inventors investigate iron homeostasis and the role of CD44-mediated iron endocytosis in the severe inflammatory response and Cytokine Release Syndrome, particularly in SARS-CoV-2 patients. The inventors demonstrate that during activation of M1 macrophages, iron endocytosis is upregulated in a CD44-dependent manner and that CD44 protein levels increase. This effect is specific to M1 macrophages, whereas levels of the canonical iron endocytosis protein TfR1/CD71 remain unchanged. In the present invention, the inventors provide in vitro evidences towards a direct role of CD44-mediated iron endocytosis in the severe inflammatory response such as Cytokine Release Syndrome observed in SARS-CoV-2 patients. Thus, the present invention relates to an antagonist of CD44/Hyaluronic Acid pathway for use in the treatment of cytokine release syndrome in a subject in need thereof, particularly severe COVID-19-related cytokine release syndrome.

公开(公告)号：EP4421081A1

公开(公告)日：2024-08-28

申请号：EP23305231.5

申请日：2023-02-22

申请人： Université de Rennes ,  École Nationale Supérieure de Chimie ,  Institut National des Sciences Appliquées de Rennes ,  Centre national de la recherche scientifique ,  Institut National de la Santé et de la Recherche Médicale ,  Ecole des Hautes Etudes en Santé Publique (EHESP)

发明人： FERRIERES, Vincent ,  SPARFEL, Lydie ,  LAGADIC-GOSSMANN, Dominique

IPC分类号： C07H7/00 ,  A01P1/00 ,  A01P3/00 ,  A01P5/00 ,  A01P7/04 ,  A01P13/00 ,  A01P21/00 ,  C07H7/02 ,  A01N43/08

CPC分类号： C07H7/00 ,  A01P1/00 ,  A01P3/00 ,  A01P13/00 ,  C07H7/02 ,  A01N43/08 ,  A01N43/16

摘要： The present invention belongs to the field of herbicidal composition. It also relates to synthesis and process for the preparation of the biocidal compound having the structure:

or salts thereof; wherein R3 one chemical group selected among an ethyl, an isopropyl, a n-butyl, an isobutyl, a cyclopentyl, a cyclohexyl, an allyl or-CH2-Ph.