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公开(公告)号：EP4442698A1
公开(公告)日：2024-10-09
申请号：EP22914735.0
申请日：2022-12-27
发明人： KE, Xiao , ZHENG, Qiang , LUO, Shuang , JIANG, Hao
IPC分类号： C07K14/015 , C12N7/00 , C12N15/35 , C12N15/864 , A61K48/00 , A61K38/00 , A61K35/76 , A61P27/02 , A61P19/02
CPC分类号： A61K35/76 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P19/06 , A61P27/06 , A61P29/00 , A61P27/02 , C07K14/015 , C12N7/00 , C12N15/864
摘要： The present invention relates to a modified adeno-associated virus (AAV) capsid protein and use thereof; said capsid protein comprises substitution of approximately 5-14 amino acids with respect to a parent AAV capsid protein; furthermore, the AAV containing the modified capsid protein has increased infectiousness with respect to a target tissue or target cell (e.g. retinal cell) in comparison with an AAV comprising an unmodified parent AAV capsid protein.
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公开(公告)号：EP4440339A1
公开(公告)日：2024-10-09
申请号：EP22823566.9
申请日：2022-12-02
申请人： N.V. Nutricia
发明人： VAN LIMPT, Cornelus Johannes Petrus , GOUW, Joost Willem , KNOL, Jan , TIMS, Sebastian , BEN AMOR, Kaouther
IPC分类号： A23L33/135 , A23L33/19 , A23L33/21 , A61K31/702 , A61P1/00
CPC分类号： A23L33/19 , A23L33/135 , A23L33/21 , A61P1/00 , A61K31/702 , A61K38/1709 , Y02A50/30
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公开(公告)号：EP3708564B1
公开(公告)日：2024-10-09
申请号：EP20156047.1
申请日：2006-12-28
IPC分类号： C07D215/56 , A61K31/47
CPC分类号： Y10T428/2982 , A61K31/47 , C07D215/56 , A61P1/00 , A61P1/12 , A61P1/18 , A61P11/00 , A61P13/02 , A61P13/12 , A61P17/00 , A61P19/08 , A61P21/00 , A61P21/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/04 , A61P3/00 , A61P35/00 , A61P3/06 , A61P37/06 , A61P43/00 , A61P5/00 , A61P5/14 , A61P5/16 , A61P7/00 , A61P7/04 , A61P7/06 , A61P7/10 , A61P7/12 , A61P3/10
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公开(公告)号：EP4438625A2
公开(公告)日：2024-10-02
申请号：EP24167555.2
申请日：2012-05-02
发明人： DILUZIO, Willow , NGUYEN, Phuong M. , VARGA, Csanad M. , PALANIAPPAN, Vaithianathan , BROWN, Jason , FOX, Irving H. , SCHOLZ, Catherine , JENKINS, Erica Helen , ROSARIO, Maria
IPC分类号： C07K16/28
CPC分类号： A61K9/0019 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/26 , A61K39/39591 , A61K2039/50520130101 , A61K2039/5420130101 , A61K2039/54520130101 , C07K2317/2420130101 , C07K16/2839 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P29/00 , A61P31/18 , A61P37/06 , A61P43/00 , A61P3/10
摘要： Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
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公开(公告)号：EP4433501A1
公开(公告)日：2024-09-25
申请号：EP22812802.1
申请日：2022-11-14
发明人： ADEDOKUN, Omoniyi , CHAN, Daphne , CHEN, Yang , SZAPARY, Philippe
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公开(公告)号：EP4429656A2
公开(公告)日：2024-09-18
申请号：EP22893676.1
申请日：2022-11-11
申请人： Atlee Biotech, inc.
发明人： SOLOMON, Atlee
IPC分类号： A61K31/352 , A61K31/35 , A61P23/02 , A61P25/04
CPC分类号： A61K31/366 , C07D307/40 , C07D407/04 , A61P1/00 , A61K31/341
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公开(公告)号：EP4427758A1
公开(公告)日：2024-09-11
申请号：EP24161191.2
申请日：2024-03-04
申请人： NOOS S.r.l.
IPC分类号： A61K35/747 , A61K31/05 , A61P29/00 , A61K35/00
CPC分类号： A61K35/747 , A61K35/00 , A61K31/05 , A61P29/00 , A61P11/00 , A61P1/00 , A61P31/00 , A61P17/00 , A61P11/02 , A61P11/04 , A23L33/105 , A23L33/135
摘要： The present invention relates to an association comprising a probiotic strain of the Lactobacillus reuteri species, both live and heat inactivated strain, and resveratrol (3,5,4'-trihydroxy-trans-stilbene), and in particular to the synergic effect shown by such association relatively to the antibacterial, antioxidant and anti-inflammatory activity with respect to the single components. The present invention, then, relates to an association between a probiotic strain of L. reuteri species and resveratrol, as well as to a pharmaceutical, cosmetic, nutraceutical composition, medical device, food supplement and a kit of parts comprising a strain of L. reuteri and resveratrol, and the use of the pharmaceutical composition, of the medical device or of the association, in a method of treatment in inflammatory pathologies.
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公开(公告)号：EP4393477A3
公开(公告)日：2024-09-11
申请号：EP24161189.6
申请日：2022-07-08
发明人： JOSHI, Vidya , ARCHBELL, James , LAMPA, Charina , MELLO, Lauren , GUTIERREZ, Gertrude , LECHUGA-BALLESTEROS, David , TAN, Penny , RIEBE, Michael , LACHACZ, Kellisa
IPC分类号： A61K31/167 , A61K31/40 , A61K31/58 , A61P1/00 , A61K9/16
CPC分类号： A61K9/008 , A61P1/00 , A61K45/06 , A61K31/58 , A61K31/167 , A61K31/40 , A61K9/1617
摘要： Compositions, methods, and systems are provided for pulmonary delivery of active agents via a metered dose inhaler. In some embodiments, the compositions comprise an HFO-1234ze(E) suspension medium, active agent particles, and suspending particles. The active agent particles may comprise one, two, three or four active agent(s) selected from a long-acting muscarinic antagonist (LAMA), a long-acting β2-agonists (LABA), a short-acting beta-agonists (SABA), an inhaled corticosteroid (ICS), and a non-corticosteroid anti-inflammatory agent.
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公开(公告)号：EP4424306A1
公开(公告)日：2024-09-04
申请号：EP22886430.2
申请日：2022-08-22
发明人： MIYANABE, Masakatsu , HIRAKI, Shinobu , ARAKAWA, Jun , KATAKURA, Yoshinori , TOKUMITSU, Yoshihiro , MATSUYAMA, Hiroyuki
IPC分类号： A61K31/164 , A23L33/10 , A61K8/68 , A61K9/107 , A61K35/57 , A61K36/06 , A61P1/00 , A61P43/00 , A61Q19/08
CPC分类号： A61P43/00 , A61K9/107 , A61K36/06 , A61P1/00 , A23L33/10 , A61K35/57 , A61K8/68 , A61Q19/08 , A61K31/164
摘要： A novel ceramide composition is provided. Specifically, an ethanol-extracted ceramide composition from chicken legs is provided.
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