公开(公告)号：EP0229830B1

公开(公告)日：1994-11-09

申请号：EP86904617.7

申请日：1986-07-02

申请人： Puget Sound Blood Center and Program ,  Fred Hutchinson Cancer Research Center

发明人： SLICHTER, Sherill J. ,  DEEG, H. Joachim

IPC分类号： A61K41/00 ,  A61M1/36

CPC分类号： A61K41/0023 ,  A61K41/0019

摘要： The immunogenicity of transfused or transplanted allogenic tissue is reduced by either directly exposing the tissue to ultraviolet (UV) irradiation prior to administering the tissue to the recipient or by inducing a state of tolerance in the recipient to non-UV or UV-irradiated allogeneic tissue by prior exposure to UV-irradiated allogenic tissue.