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204 条记录 (耗时 0.029 秒)

    NON-INVASIVE SYSTEMS AND METHODS FOR TREATMENT OF A HOST CARRYING A VIRUS WITH PHOTOACTIVATABLE DRUGS
    1.
    发明公开
    NON-INVASIVE SYSTEMS AND METHODS FOR TREATMENT OF A HOST CARRYING A VIRUS WITH PHOTOACTIVATABLE DRUGS 审中-公开

    公开(公告)号：EP3244928A4

    公开(公告)日：2018-08-01

    申请号：EP16737798

    申请日：2016-01-13

    申请人： IMMUNOLIGHT LLC

    发明人： BOURKE FREDERIC AVERY ,  WALDER HAROLD

    IPC分类号： A61K41/00 ,  A61N5/06 ,  A61N5/10

    CPC分类号： A61K41/0066 ,  A61K41/0019 ,  A61K41/0057

    摘要： Products, compositions, systems, and methods for treating a subject carrying a virus or bacterium. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to the subject thus producing an effect on or change to a target structure of the subject directly or indirectly. The methods may further be performed by application of an initiation energy to a subject to activate within the subject a photoactivatable drug directly or indirectly, optionally in the presence of one or more plasmonics active agents, thus treating the virus or bacterium. Also provided are kits containing products or compositions formulated or configured and systems for use in practicing these methods.

    NON-INVASIVE SYSTEMS AND METHODS FOR TREATMENT OF A HOST CARRYING A VIRUS WITH PHOTOACTIVATABLE DRUGS
    3.
    发明公开
    NON-INVASIVE SYSTEMS AND METHODS FOR TREATMENT OF A HOST CARRYING A VIRUS WITH PHOTOACTIVATABLE DRUGS 审中-公开
    用可光活性药物治疗携带病毒的宿主的非侵入系统和方法

    公开(公告)号：EP3244928A1

    公开(公告)日：2017-11-22

    申请号：EP16737798.5

    申请日：2016-01-13

    申请人： Immunolight, LLC.

    发明人： BOURKE, Frederic Avery ,  WALDER, Harold

    IPC分类号： A61K41/00

    CPC分类号： A61K41/0066 ,  A61K41/0019 ,  A61K41/0057

    摘要： Products, compositions, systems, and methods for treating a subject carrying a virus or bacterium. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to the subject thus producing an effect on or change to a target structure of the subject directly or indirectly. The methods may further be performed by application of an initiation energy to a subject to activate within the subject a photoactivatable drug directly or indirectly, optionally in the presence of one or more plasmonics active agents, thus treating the virus or bacterium. Also provided are kits containing products or compositions formulated or configured and systems for use in practicing these methods.

    CARBORANYLPORPHYRINS AND USES THEREOF
    8.
    发明公开
    CARBORANYLPORPHYRINS AND USES THEREOF 有权
    CARBORANYLPORPHYRINE和IHRE VERWENDUNGEN

    公开(公告)号：EP2099304A4

    公开(公告)日：2011-03-16

    申请号：EP07874160

    申请日：2007-12-03

    申请人： BROOKHAVEN SCIENCES ASS LLC

    发明人： MIURA MICHIKO ,  RENNER MARK W

    IPC分类号： A01N55/02 ,  A61K31/555

    CPC分类号： A61K51/00 ,  A61K41/0019 ,  A61K41/0071 ,  A61K41/0095 ,  A61K49/106 ,  A61K51/0485 ,  C07D487/22 ,  C07F5/027

    摘要： The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing porphyrin compounds with halide, amine, or nitro groups and methods for their use particularly in boron neutron capture therapy (BNCT), X-ray radiation therapy (XRT), and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing porphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.

    摘要翻译： 本发明涉及低毒性硼化化合物及其用于肿瘤的治疗，可视化和诊断的方法。 更具体地说，本发明涉及具有卤化物，胺或硝基的低毒性含碳硼烷的卟啉化合物及其特别用于硼中子俘获疗法（BNCT），X射线放射疗法（XRT）和光动力学 治疗（PDT）用于治疗脑，头和颈部肿瘤以及周围组织。 本发明还涉及在肿瘤成像和/或诊断方法如MRI，SPECT或PET中使用这些含碳硼烷的卟啉化合物。

    INTEGRATED PHOTOACTIVE SMALL MOLECULES AND USES THEREOF
    10.
    发明公开
    INTEGRATED PHOTOACTIVE SMALL MOLECULES AND USES THEREOF 审中-公开
    集成光电活性小分子及其用途

    公开(公告)号：EP2131861A2

    公开(公告)日：2009-12-16

    申请号：EP08726104.6

    申请日：2008-02-26

    申请人： Mallinckrodt Inc.

    发明人： NEUMANN, William, L. ,  RAJAGOPALAN, Raghavan ,  MOORE, Dennis, A. ,  DORSHOW, Richard, B.

    IPC分类号： A61K41/00 ,  A61K49/00 ,  C07D241/26

    CPC分类号： A61K49/001 ,  A61K41/0019 ,  A61K47/60 ,  A61K49/0021 ,  A61K49/0052

    摘要： This invention is directed to the general method of transforming non-photoactive bioactive small molecule compounds of known structure and function into photoactive analogs of the small molecules which exhibit both photoactivity and the original biological targeting activity. The general method for the design of the photoactive analogs of the small molecules includes: (a) selecting a desired bioactive molecule; (b) identifying the region of the molecule that contains an aromatic or a heteroaromatic motif; and (c) either replacing said motif with a photoactive functional group of similar size, or modifying said motif to make it photoactive. Other aspects include photoactive analog compounds and photodiagnostic and phototherapeutic uses thereof.