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    A PEPTIDE MIXTURE
    4.
    发明公开
    A PEPTIDE MIXTURE 有权
    PEPTIDMISCHUNG

    公开(公告)号：EP3079715A2

    公开(公告)日：2016-10-19

    申请号：EP14828148.8

    申请日：2014-12-09

    申请人： TARGOVAX ASA

    发明人： ERIKSEN, Jon Amund

    IPC分类号： A61K39/00 ,  C07K14/47 ,  A61P35/00 ,  C07K14/82

    CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K2039/5158 ,  A61K2039/57 ,  A61K2039/70 ,  C07K14/82 ,  C12Q2600/156 ,  G01N33/483 ,  G01N33/505 ,  G01N2333/47

    摘要： There is disclosed a peptide mixture suitable for eliciting an immune response. It comprises a first and a second peptide, each corresponding to a fragment of the RAS protein. Each of the first and second peptides comprises a region of at least 8 amino acids which includes position 13 of the RAS protein. Each of said regions of the first and second peptides independently has at least 6 amino acid residues, other than at said position 13, which are identical to the corresponding region of the RAS protein. Each of the first and the second peptides has a point mutation at the amino acid corresponding to said position 13. The point mutation of the first peptide is different from the point mutation of the second peptide.

    摘要翻译： 公开了适于引发免疫应答的肽混合物。 它包含第一和第二肽，每个肽对应于RAS蛋白的片段。 第一和第二肽中的每一个包含至少8个氨基酸的区域，其包括RAS蛋白质的第13位。 第一和第二肽的每个所述区域独立地具有至少6个氨基酸残基，而不是在所述位置13，其与RAS蛋白质的相应区域相同。 第一和第二肽中的每一个在对应于所述位置13的氨基酸处具有点突变。第一肽的点突变不同于第二肽的点突变。

    ONCOLYTIC ADENOVIRAL VECTOR EXPRESSING GRANZYME AND PERFORIN
    6.
    发明公开
    ONCOLYTIC ADENOVIRAL VECTOR EXPRESSING GRANZYME AND PERFORIN 审中-公开

    公开(公告)号：EP3725322A1

    公开(公告)日：2020-10-21

    申请号：EP19169818.2

    申请日：2019-04-17

    申请人： TARGOVAX ASA

    发明人： KURYK, Lukasz ,  ERIKSEN, Jon Amund ,  SKORPIL, Peter ,  BURNS, Robert ,  MØLLER, Anne-Sophie

    IPC分类号： A61K35/761 ,  A61K48/00 ,  C07K14/47 ,  C12N9/64 ,  C12N15/86

    摘要： The present invention relates to cancer therapies. More specifically, the present invention relates to oncolytic adenoviral vectors and cells and pharmaceutical compositions comprising said vectors. The present invention also relates to a use of said vectors in the manufacture of a medicament for treating cancer in a subject and a method of treating cancer in a subject. Furthermore, the present invention relates to methods of producing granzyme and perforin in a cell and increasing anti-tumor effect and induction of specific immune response in a subject, as well as uses of the oncolytic adenoviral vector of the invention for producing transgenes in a cell and increasing anti-tumor effect and generation of specific immune response in a subject.

    A PEPTIDE MIXTURE
    8.
    发明公开
    A PEPTIDE MIXTURE 审中-公开

    公开(公告)号：EP3369432A1

    公开(公告)日：2018-09-05

    申请号：EP18166278.4

    申请日：2014-12-09

    申请人： TARGOVAX ASA

    发明人： ERIKSEN, Jon Amund

    IPC分类号： A61K39/00 ,  C07K14/47 ,  A61P35/00 ,  C07K14/82

    CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K2039/5158 ,  A61K2039/57 ,  A61K2039/70 ,  C07K14/82 ,  C12Q2600/156 ,  G01N33/483 ,  G01N33/505 ,  G01N2333/47

    摘要： There is disclosed a peptide mixture suitable for eliciting an immune response. It comprises a first, a second and at least one further peptide, each corresponding to a fragment of the RAS protein. Each of the first and second peptides comprises a region of at least 8 amino acids which includes position 13 of the RAS protein, and each of said regions independently has at least 6 amino acid residues, other than at said position 13, which are identical to the corresponding region of the RAS protein. Each of the first and the second peptides has an amino acid substitution at the amino acid corresponding to said position 13, wherein the amino acid substitution of the first peptide is different from the amino acid substitution of the second peptide. The at least one further peptide comprises a region of at least 8 amino acids which includes position 12 of the RAS protein, wherein each of said regions independently has at least 6 amino acid residues, other than at said position 12, which are identical to the corresponding region of the RAS protein, and wherein there is an amino acid substitution at the amino acid corresponding to position 12 of the RAS protein; and/or the at least one further peptide comprises a region of a least 8 amino acids which includes position 61 of the RAS protein, wherein each of said regions independently has at least 6 amino acid residues, other than at said position 61, which are identical to the corresponding region of the RAS protein, and wherein there is an amino acid substitution at the amino acid corresponding to position 61 of the RAS protein.

    A PEPTIDE MIXTURE
    9.
    发明公开
    A PEPTIDE MIXTURE 审中-公开

    公开(公告)号：EP3363457A1

    公开(公告)日：2018-08-22

    申请号：EP18166279.2

    申请日：2014-12-09

    申请人： TARGOVAX ASA

    发明人： ERIKSEN, Jon Amund

    IPC分类号： A61K39/00 ,  C07K14/47 ,  A61P35/00 ,  C07K14/82

    CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K2039/5158 ,  A61K2039/57 ,  A61K2039/70 ,  C07K14/82 ,  C12Q2600/156 ,  G01N33/483 ,  G01N33/505 ,  G01N2333/47

    摘要： There is disclosed a peptide mixture suitable for eliciting an immune response. It consists of six peptides each corresponding to a fragment of the RAS protein wherein each peptide comprises a region of at least 8 amino acids which includes position 12 of the RAS protein. Each of said regions of the peptides independently has at least 6 amino acid residues other than at said position 12, which are identical to the corresponding region of the RAS protein. Each of the peptides has an amino acid substitution at the amino acid corresponding to said position 12, selected from a G12A, G12C, G12D, G12R, G12S or a G12V substitution, and the amino acid substitution of each peptide is different from the amino acid substitution of the other peptides..

    A PEPTIDE MIXTURE
    10.
    发明授权
    A PEPTIDE MIXTURE 有权

    公开(公告)号：EP3079715B1

    公开(公告)日：2018-06-13

    申请号：EP14828148.8

    申请日：2014-12-09

    申请人： TARGOVAX ASA

    发明人： ERIKSEN, Jon Amund

    IPC分类号： A61K39/00 ,  C07K14/47 ,  A61P35/00 ,  C07K14/82

    CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K2039/5158 ,  A61K2039/57 ,  A61K2039/70 ,  C07K14/82 ,  C12Q2600/156 ,  G01N33/483 ,  G01N33/505 ,  G01N2333/47

    摘要： There is disclosed a peptide mixture suitable for eliciting an immune response. It comprises a first and a second peptide, each corresponding to a fragment of the RAS protein. Each of the first and second peptides comprises a region of at least 8 amino acids which includes position 13 of the RAS protein. Each of said regions of the first and second peptides independently has at least 6 amino acid residues, other than at said position 13, which are identical to the corresponding region of the RAS protein. Each of the first and the second peptides has a point mutation at the amino acid corresponding to said position 13. The point mutation of the first peptide is different from the point mutation of the second peptide.