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1.发明公开PEPTIDE VACCINE COMPRISING MUTANT RAS PEPTIDE AND CHEMOTHERAPEUTIC AGENT 审中-公开化学疗法中的PEPTIDIMPFSTOFF MIT MUTIERTEM RAS-PEPTID UND CHEMOTHERAPEUTIKUM
公开(公告)号：EP3140320A1
公开(公告)日：2017-03-15
申请号：EP15720986.7
申请日：2015-05-05
申请人： TARGOVAX ASA
CPC分类号： A61K39/0011 , A61K31/7068 , A61K35/17 , A61K45/06 , A61K2039/5158 , A61K2039/545 , A61K2039/55522 , A61K2039/585 , C07K14/82 , A61K2300/00
摘要： There is disclosed at least one peptide suitable for eliciting an immune response, for use in the treatment of cancer. The, or each, peptide corresponds to a fragment of the RAS protein, but has one to three point mutations thereof. The at least one peptide is for use in the treatment of cancer by simultaneous or sequential administration with an anti-metabolite chemotherapeutic agent.
摘要翻译： 公开了至少一种适用于引发免疫应答的肽，用于治疗癌症。 肽或每个肽对应于RAS蛋白的片段，但具有一至三个点的突变。 所述至少一种肽用于通过与抗代谢物化学治疗剂同时或连续给药来治疗癌症。
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公开(公告)号：EP3140320B1
公开(公告)日：2018-12-26
申请号：EP15720986.7
申请日：2015-05-05
申请人： TARGOVAX ASA
IPC分类号： C07K14/82 , A61K39/00 , A61K45/06 , A61K31/7068 , A61K35/17
CPC分类号： A61K39/0011 , A61K31/7068 , A61K35/17 , A61K45/06 , A61K2039/5158 , A61K2039/545 , A61K2039/55522 , A61K2039/585 , C07K14/82 , A61K2300/00
摘要： There is disclosed at least one peptide suitable for eliciting an immune response, for use in the treatment of cancer. The, or each, peptide corresponds to a fragment of the RAS protein, but has one to three point mutations thereof. The at least one peptide is for use in the treatment of cancer by simultaneous or sequential administration with an anti-metabolite chemotherapeutic agent.
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