公开(公告)号：EP1712634A1

公开(公告)日：2006-10-18

申请号：EP05290815.9

申请日：2005-04-13

申请人： Wittycell SAS

发明人： Bernard, Jacky ,  Millard, Anne-Laure

IPC分类号： C12Q1/00 ,  G01N33/50 ,  A61K45/00

CPC分类号： G01N33/5047 ,  A61K39/0011 ,  A61K45/06 ,  A61K2039/5154 ,  G01N33/5005

摘要： The present invention relates, generally, to the fields of immunology and cellular biology. The invention discloses, more particularly, a new strategy of modulation of immune response based on the use of highly efficient non autologous antigen presenting and/or immunostimulatory system such as allogeneic antigen presenting cells. Invention thus relates to methods for preparing or selecting systems having high antigen presentation and/or immunostimulatory capacity for a given subject. The invention also discloses banks usable to select such systems as well as compositions comprising such systems, their preparation and uses.

摘要翻译： 本发明涉及，基因反弹，免疫学和细胞生物学的领域。 本发明的圆盘更小，更具体地，基于使用高效的非自体抗原呈递和/或免疫刺激系统的免疫应答的调制的新策略：如同种异体抗原呈递细胞。 因此，本发明涉及用于制备或具有高的抗原呈递和/或免疫刺激能力针对给定的受试者选择系统的方法。 因此，本发明松散盘银行可用来选择搜索系统以及组合物，包含搜索系统，它们的制备和用途。

公开(公告)号：EP2231145B1

公开(公告)日：2014-09-17

申请号：EP08872320.0

申请日：2008-12-05

申请人： Wittycell

发明人： SERRA, Vincent

IPC分类号： A61K31/35 ,  A61K39/39 ,  C07D309/10 ,  C07H5/06 ,  A61P37/04

CPC分类号： C07D309/10 ,  A61K31/35 ,  A61K39/39 ,  A61K2039/55511 ,  C07H5/06 ,  C07H15/04 ,  C07H15/06 ,  C07H15/10

公开(公告)号：EP2060252A1

公开(公告)日：2009-05-20

申请号：EP07291378.3

申请日：2007-11-19

申请人： Wittycell

发明人： Serra, Vincent

IPC分类号： A61K9/127 ,  A61K9/107 ,  A61K47/28 ,  A61K47/18 ,  A61K31/7032 ,  A61K31/7028 ,  A61K39/39

CPC分类号： A61K31/7028 ,  A61K9/1075 ,  A61K31/7032 ,  A61K47/26 ,  A61K47/28

摘要： The present invention relates to a composition comprising at least one derivative of galactosylceramides, and at least one bile salt, such as sodium taurocholate or sodium deoxycholate.
It also relates to a method for the preparation of said composition, comprising the co-solubilization of the derivative of galactosylceramides and the bile salt into a solvent, followed by the evaporation of said solvent.

摘要翻译： 本发明涉及包含半乳糖神经酰胺的至少一种衍生物和至少一种胆汁盐如牛磺胆酸钠或脱氧胆酸钠的组合物。 它还涉及制备所述组合物的方法，其包括将半乳糖神经酰胺衍生物和胆汁盐共溶解到溶剂中，然后蒸发所述溶剂。

公开(公告)号：EP2727929A1

公开(公告)日：2014-05-07

申请号：EP12306355.4

申请日：2012-10-30

申请人： Wittycell

发明人： Serra, Vincent

IPC分类号： C07H15/04 ,  C07H15/18 ,  C07C217/28

CPC分类号： C07H15/26 ,  C07D317/28 ,  C07H15/04 ,  C07H15/06 ,  C07H15/18

摘要： The present invention relates to a method of preparation of α-galactosyl ceramides compounds of formula (I):

comprising a step a) of glycosylation of a compound of formula (II):

with a compound of formula (III):

摘要翻译： 本发明涉及式（I）的± - 半乳糖神经酰胺化合物的制备方法：包括式（II）化合物与式（III）化合物糖基化的步骤a）：

公开(公告)号：EP2190475A1

公开(公告)日：2010-06-02

申请号：EP08875737.2

申请日：2008-08-29

申请人： Wittycell

发明人： SERRA, Vincent

IPC分类号： A61K39/39 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/739

CPC分类号： A61K39/39 ,  A61K2039/55511

摘要： The immunogenicity of vaccines is enhanced by co-administering a synthetic glycolipid, designated PBS-57, with the vaccine. PBS-57 has the ability to stimulate both a cell-mediated and humoral immune response. Co-administration of PBS-57 with a vaccine may be used in methods to stimulate one or more of a humoral immune response, a CD4+ T cell response, and a CD8+ cytotoxic T cell response.

公开(公告)号：EP2058011A1

公开(公告)日：2009-05-13

申请号：EP07291336.1

申请日：2007-11-07

申请人： Wittycell

发明人： Serra Vincent

IPC分类号： A61K47/48 ,  A61K39/385 ,  C07H15/06

CPC分类号： C07H15/06 ,  A61K39/385 ,  A61K47/549 ,  A61K47/646 ,  A61K2039/57 ,  A61K2039/6018

摘要： The present invention relates to compounds consisting of glycolipids covalently bound to an antigen or a drug via a linker. The said compounds are able to induce a stronger immune response than a composition comprising separated glycolipids and antigen. The said compounds are also able to target drug to CD1d restricted cells.

摘要翻译： 本发明涉及由通过接头共价结合抗原或药物的糖脂组成的化合物。 所述化合物能够诱导比包含分离的糖脂和抗原的组合物更强的免疫应答。 所述化合物还能够将药物靶向CD1d限制性细胞。

公开(公告)号：EP2341931A1

公开(公告)日：2011-07-13

申请号：EP09783735.5

申请日：2009-10-05

申请人： Wittycell ,  Serra, Vincent

发明人： SERRA, Vincent

IPC分类号： A61K39/145

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/58 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16234

摘要： The present invention relates to a vaccine composition comprising: - at least one prophylactically active agent against influenza, and - at least one adjuvant, said adjuvant being a derivative of a galactosylceramide, for use in the treatment of influenza.

公开(公告)号：EP2231196A2

公开(公告)日：2010-09-29

申请号：EP08846406.0

申请日：2008-11-07

申请人： Wittycell

发明人： SERRA, Vincent

IPC分类号： A61K47/48 ,  A61K39/385 ,  C07H15/06

CPC分类号： C07H15/06 ,  A61K39/385 ,  A61K47/549 ,  A61K47/646 ,  A61K2039/57 ,  A61K2039/6018

摘要： The present invention relates to compounds consisting of glycolipids covalently bound to an antigen or a drug via a linker. The said compounds are able to induce a stronger immune response than a composition comprising separated glycolipids and antigen. The said compounds are also able to target drug to CD1d restricted cells.

公开(公告)号：EP2231145A2

公开(公告)日：2010-09-29

申请号：EP08872320.0

申请日：2008-12-05

申请人： Wittycell

发明人： SERRA, Vincent

IPC分类号： A61K31/35 ,  A61K39/39 ,  C07D309/10 ,  C07H5/06 ,  A61P37/04

CPC分类号： C07D309/10 ,  A61K31/35 ,  A61K39/39 ,  A61K2039/55511 ,  C07H5/06 ,  C07H15/04 ,  C07H15/06 ,  C07H15/10

摘要： Compositions comprising the compound of formula are provided herein. Also provided are methods of enhancing an immune response of a subject to an antigen by administering the antigen and the composition. The enhanced immune response may be an humoral immune response, a CD4+ T cell response, a CD8+ T cell response or result in activation of antigen presenting cells. Methods of enhancing the immune response by intramuscular administration of an antigen and the composition including the compound of formula I are also provided.

公开(公告)号：EP1882041A2

公开(公告)日：2008-01-30

申请号：EP06744824.1

申请日：2006-04-12

申请人： Wittycell SAS

发明人： BERNARD, Jacky ,  MILLARD, Anne-Laure

IPC分类号： C12Q1/00 ,  G01N33/50 ,  A61K45/00

CPC分类号： G01N33/5047 ,  A61K39/0011 ,  A61K45/06 ,  A61K2039/5154 ,  G01N33/5005

摘要： The present invention relates, generally, to the fields of immunology and cellular biology. The invention discloses, more particularly, a new strategy of modulation of immune response based on the use of highly efficient non autologous antigen presenting and/or immunostimulatory system such as allogeneic antigen presenting cells. Invention thus relates to methods for preparing or selecting systems having high antigen presentation and/or immunostimulatory capacity for a given subject. The invention also discloses banks usable to select such systems as well as compositions comprising such systems, their preparation and uses.