公开(公告)号：EP4410802A2

公开(公告)日：2024-08-07

申请号：EP24169316.7

申请日：2019-02-12

Applicant: INIMMUNE CORPORATION

Inventor： Bazin-Lee, Helene ,  Ettenger, George ,  Khalaf, Juhienah ,  Ryter, Kendal T.

IPC: C07H15/12

CPC classification number: A61K39/39 ,  A61P31/04 ,  A61K39/12 ,  C12N2760/1613420130101 ,  A61K2039/5551120130101 ,  A61K45/06 ,  A61K31/7008 ,  C07H15/12 ,  C07H15/04

Abstract: Toll-like receptor (TLR) ligands having an allose-based core are stable in aqueous formulation and are useful in treating, preventing, or reducing susceptibility to diseases or conditions mediated by TLRs, such as cancer, infectious disease, allergy, autoimmune disease, sepsis, and ischemia reperfusion.

公开(公告)号：EP4408173A1

公开(公告)日：2024-08-07

申请号：EP22877131.7

申请日：2022-09-18

Applicant: Pheronym Inc. ,  Kaplan, Fatma

Inventor： KAPLAN, Fatma

IPC: A01N43/16 ,  A01P21/00 ,  A01N63/12 ,  C07H15/00

CPC classification number: A01P21/00 ,  A01N43/16 ,  A01N63/12 ,  C07H15/04

公开(公告)号：EP3888685B1

公开(公告)日：2024-07-31

申请号：EP19889346.3

申请日：2019-12-02

IPC: A61K47/54 ,  A61K47/56 ,  C07H15/04 ,  A61K31/198 ,  A61K47/61 ,  A61P1/16

CPC classification number: A61P1/16 ,  A61K47/549 ,  C07H15/04 ,  A61K31/198 ,  A61K47/56 ,  Y02P20/55

公开(公告)号：EP4359419A1

公开(公告)日：2024-05-01

申请号：EP22733758.1

申请日：2022-06-21

Applicant: Pharmacytics B.V.

Inventor： HAJJAJ, Bouchra ,  MACCORMICK, Somhairle ,  VEENEMAN, Gerrit Herman

IPC: C07H13/12 ,  C07H15/04 ,  C07H15/26

CPC classification number: C07H15/18 ,  C07H15/26 ,  C07H13/12 ,  C07H15/04

公开(公告)号：EP3389669A1

公开(公告)日：2018-10-24

申请号：EP16876910.7

申请日：2016-12-19

Applicant: Memorial Sloan-Kettering Cancer Center

Inventor： TAN, Derek S. ,  GIN, David Y. ,  WALKOWICZ, William E. ,  FERNANDEZ-TEJADA, Alberto ,  RAGUPATHI, Govindaswami

IPC: A61K31/7024 ,  C07H13/02 ,  C07H13/06

CPC classification number: C07H13/06 ,  C07H13/02 ,  C07H15/04 ,  C07H15/24

Abstract: A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.

公开(公告)号：EP3387000A1

公开(公告)日：2018-10-17

申请号：EP16825461.3

申请日：2016-12-09

Applicant: École Nationale Supérieure De Chimie

Inventor： BENVEGNU, Thierry ,  SARI-CHMAYSSEM, Nouha ,  TAHA, Samir ,  MAWLAWI, Hiba

IPC: C07H7/033 ,  C07H15/04

CPC classification number: C07H15/04 ,  A01N43/08 ,  A01N43/16 ,  B01F17/0042 ,  B01F17/0092 ,  C07H1/00 ,  C11D1/662 ,  C11D1/825

Abstract: The present invention relates to a novel method for obtaining surfactant compositions made from alkyl-L-guluronamides or mixtures of L-guluronamides and D-mannuronamides, the compositions obtained by said method and the uses thereof.

公开(公告)号：EP3024842B1

公开(公告)日：2018-10-17

申请号：EP13890188.9

申请日：2013-07-25

Applicant: ScinoPharm Taiwan, Ltd.

Inventor： KUO, Lung-Huang ,  CHEN, Shang-Hong ,  WANG, Li-Ting ,  SHIH, Wen-Li ,  LIAO, Yuan-Xiu

IPC: C07H1/00 ,  C07H15/14 ,  C07H15/18 ,  C07H15/203 ,  C07H15/04 ,  A61K31/7024

CPC classification number: C07H15/203 ,  C07H1/00 ,  C07H15/04 ,  C07H15/14 ,  C07H15/18

Abstract: The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.

公开(公告)号：EP3336095A1

公开(公告)日：2018-06-20

申请号：EP16799269.2

申请日：2016-05-20

Applicant: Shanghai Green Valley Pharmaceutical Co., Ltd.

Inventor： ZHANG, Zhenqing ,  HAO, Jie ,  SUN, Shichang ,  ZHANG, Huiling

IPC: C07H15/04 ,  C07H1/00 ,  A61P9/10 ,  A61P25/00 ,  C08B37/02

CPC classification number: A61K31/715 ,  A61P9/10 ,  A61P25/00 ,  C07H1/00 ,  C07H15/04

Abstract: The present invention relates to the technical field of medical compounds, and relates to an oxidized β-1,4-oligoglucuronic acid, and a preparation method therefor and uses thereof. In the present invention, by using abundant cellulose in the natural world as the raw material, all 6-site hydroxyl groups of the cellulose β-1,4-polyglucose is oxidized into carboxyl groups to form glucuronic acid under the action of a sodium bromide (NaBr)-2,2,6,6-tetramethyl piperidine oxide (TEMPO)-sodium hypochlorite (NaClO)oxidation system, and the oxidized oligoglucuronic acid having an open ring at an end is prepared by controlling reaction conditions. The compound has obvious anti-cerebral ischemia activity, and can be developed into a potential anti-cerebral ischemia drug.

公开(公告)号：EP3296309A8

公开(公告)日：2018-06-06

申请号：EP17178121.4

申请日：2013-06-20

Applicant: Universiteit Gent

Inventor： ELEWAUT, Dirk ,  PAUWELS, Nora ,  ASPESLAGH, Sandrine ,  VAN CALENBERGH, Serge

IPC: C07H15/04 ,  A61K31/7032 ,  A61P31/00 ,  A61P35/00

CPC classification number: C07H15/26 ,  C07H15/04 ,  C07H15/18

Abstract: This invention relates to carbamate-containing or thiocarbamate-containing galacto-pyranosyl compounds useful as therapeutic agents and being represented by the structural formula (II), wherein: X is O or S, R is selected from the group consisting of C1-8 alkyl, C3-10 cycloalkyl, aryl-C1-4 alkyl, heterocyclyl-C1-4 alkyl, cycloalkyl-C1-4 alkyl, aryl and heterocyclyl, wherein R is optionally substituted with one or more R9; R2, R3, R4, R6 and R7 are independently selected from the group consisting of hydroxyl and protected hydroxyl groups; R5 is selected from the group consisting C6-30 alkyl and arylalkyl; R8 is C6-30 alkyl; and each R9 is independently selected from the group consisting of halogen, hydroxy, trifluoromethyl, trifluoromethoxy, C1-8 alkoxy, C1-6 alkyl, cyano, methylthio, phenyl, phenoxy, chloromethyl, dichloromethyl, chloro-difluoromethyl, acetyl, nitro, benzyl, heterocyclyl and di-C1-4 alkyl-amino, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP2673000B1

公开(公告)日：2018-05-16

申请号：EP12704348.7

申请日：2012-02-03

Applicant: Wu, Nian

Inventor： Wu, Nian

IPC: A61K47/60

CPC classification number: C07H1/00 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0095 ,  A61K9/2013 ,  A61K31/05 ,  A61K31/223 ,  A61K31/231 ,  A61K31/25 ,  A61K31/325 ,  A61K31/4188 ,  A61K31/575 ,  A61K31/7032 ,  A61K47/26 ,  C07H15/04 ,  C07J41/0061 ,  C08G65/329 ,  C08L2203/02

Abstract: The invention comprises compounds, methods of making, and methods of using. The compounds may have a backbone and three appended functional groups: one lipid, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. A variety of linkers between the backbone and functional groups may also be selected to optimize performance.