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    A method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a nonaqueous matrix
    2.
    发明公开
    A method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a nonaqueous matrix 失效
    一种防止在非质子基质中液体分散中的晶体水合物形成的方法

    公开(公告)号：EP0304227A3

    公开(公告)日：1989-06-28

    申请号：EP88307450.2

    申请日：1988-08-11

    申请人： ALZA CORPORATION

    发明人： Campbell, Patricia S. ,  Enscore, David J. ,  Gale, Robert M. ,  Kaufman, Arnold

    IPC分类号： A61L15/16 ,  A61K9/70

    CPC分类号： A61K9/7053 ,  A61K9/7084

    摘要： A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises forming individual subunits from such dispersions, heating the subunits, preferably after they have been packed in sealed containers, to a temperature high enough to melt the crystalline hydrate, maintaining said subunits at such temperature for a time sufficient to melt all the crystalline hydrate present and to prevent the occurrence of crystals for an extended period of time after cooling and cooling subunits to ambient conditions. The use of the method in the manufacture of transdermal delivery devices for the delivery of scopolamine base is described.

    Transdermal system II
    3.
    发明公开
    Transdermal system II 失效
    经典Vorrichtung。

    公开(公告)号：EP0232580A2

    公开(公告)日：1987-08-19

    申请号：EP86306493.7

    申请日：1986-08-21

    申请人： ALZA CORPORATION

    发明人： Campbell, Patricia S. ,  Eckenhoff, James B. ,  Place, Virgil A.

    IPC分类号： A61M35/00 ,  A61F13/02 ,  A61M37/00

    CPC分类号： A61K9/7053 ,  A61K9/0034 ,  A61K9/0041 ,  A61K9/7069 ,  Y10S424/14

    摘要： A transdermal therapeutic system is provided which is adapted for delivery of a biologically active agent over an extended time period said system comprising a matrix containing an agent disposed therein, the intended body distal surface of said matric having fibrous reinforcing means embedded therein, said matrix being capable of firm adhesion to the skin but with a peel strength sufficiently low for removal without discomfort.
    The reinforcing means comprises a stretchable fabric formed of either randomly or orientated bonded fibres to form an isotrophic web substantially equally deformable in all directions, or anisotrophic web formed of a multiplicity of continuous generally parallel fibres having randomly orientated second fibres bonded transversly thereto so as to be deformable primarily in a direction perpendicular to the continuous fibres.

    摘要翻译： 提供了经皮治疗系统，其适于在延长的时间段内递送生物活性剂，所述系统包含含有置于其中的药剂的基质，所述基质的预期身体远端表面具有嵌入其中的纤维增强装置，所述基质为 能够牢固地粘附到皮肤上，但具有足够低的剥离强度以便去除而不舒服。 增强装置包括由随机或取向的结合纤维形成的可拉伸织物，以形成在所有方向上基本上可等同变形的同质网，或由多个具有随机取向的第二纤维横向粘结的多个连续的大致平行的纤维形成的各向异性腹板，以便 可以主要在垂直于连续纤维的方向上变形。

    Novel formulations for the transdermal administration of fluoxetine
    6.
    发明公开
    Novel formulations for the transdermal administration of fluoxetine 失效
    Neue Formulierungen zur transdermale Verabreichung von Fluoxetin

    公开(公告)号：EP1393724A2

    公开(公告)日：2004-03-03

    申请号：EP03022248.3

    申请日：1997-07-15

    申请人： ALZA CORPORATION

    发明人： Gale, Robert M. ,  Nelson, Melinda K. ,  Cormier, Michael J.N. ,  Gupta, Suneel K. ,  Campbell, Patricia S.

    IPC分类号： A61K31/138 ,  A61K9/70

    CPC分类号： A61K9/7084 ,  A61K31/135

    摘要： A device for the transdermal administration of fluoxetine (10) at a therapeutically effective rate comprises:

    (a) a reservoir (12) containing a composition comprising an amount of a pharmaceutically acceptable salt of fluoxetine;
    (b) a backing (14) behind the body contacting-distal surface of the reservoir; and
    (c) means (16) for maintaining the reservoir in fluoxetine transmitting relation with a body surface or membrane.

    摘要翻译： 用于以治疗有效速率透皮施用氟西汀（10）的装置包括：（a）含有一定量的药物可接受的氟西汀盐的组合物的储存器（12） （b）在容器的身体接触远侧表面后面的背衬（14）; 和（c）用于维持储存器与体表或膜的氟西汀传递关系的装置（16）。

    A method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a nonaqueous matrix
    7.
    发明公开
    A method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a nonaqueous matrix 失效
    一种用于防止结晶水合物的形成在液体中的分散体在非水性基质方法。

    公开(公告)号：EP0304227A2

    公开(公告)日：1989-02-22

    申请号：EP88307450.2

    申请日：1988-08-11

    申请人： ALZA CORPORATION

    发明人： Campbell, Patricia S. ,  Enscore, David J. ,  Gale, Robert M. ,  Kaufman, Arnold

    IPC分类号： A61L15/16 ,  A61K9/70

    CPC分类号： A61K9/7053 ,  A61K9/7084

    摘要： A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises forming individual subunits from such dispersions, heating the subunits, preferably after they have been packed in sealed containers, to a temperature high enough to melt the crystalline hydrate, maintaining said subunits at such temperature for a time sufficient to melt all the crystalline hydrate present and to prevent the occurrence of crystals for an extended period of time after cooling and cooling subunits to ambient conditions. The use of the method in the manufacture of transdermal delivery devices for the delivery of scopolamine base is described.

    摘要翻译： 一种用于在非水基质防止水螅表液体中的分散体的结晶水合物的形成方法是游离缺失盘。 该方法是在从寻求分散体形成的层叠件的制造中是特别有用的，并且包括从寻求分散体形成单个亚基，加热该亚基被全心全意装在密封的容器优选后，以高到足以熔融所述结晶水合物的温度，保持 所述亚基在寻求温度足够长的时间，以熔化所有的结晶水合物存在，并且以防止晶体的发生在延长的时间期间冷却和冷却亚基至环境条件之后。 在为东莨菪碱碱的递送经皮递送装置的制造中使用的方法进行说明。

    Novel formulations for transdermal delivery of pergolide
    8.
    发明公开
    Novel formulations for transdermal delivery of pergolide 失效
    Neue Zusammensetzungen zur transdermalen Verabrechung von Pergolid

    公开(公告)号：EP1428527A1

    公开(公告)日：2004-06-16

    申请号：EP04075596.9

    申请日：1996-06-07

    申请人： ALZA Corporation

    发明人： Yum, Su II ,  Nelson, Melinda K. ,  Campbell, Patricia S.

    IPC分类号： A61K9/70 ,  A61K31/48 ,  A61P25/16

    CPC分类号： A61K9/7053 ,  A61K9/0014 ,  A61K9/7084 ,  A61K31/48 ,  A61K47/14 ,  A61K47/18 ,  Y10S514/947

    摘要： Composition of matter for application to a body surface or membrane to administer pergolide by permeation through the body surface or membrane, the composition comprising pergolide to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices containing the pergolide or pergolide and enhancer composition and methods for the transdermal administration of the pergolide and pergolide/enhancer composition.

    摘要翻译： 用于通过穿过身体表面或膜渗透的身体表面或膜施用培高利特的物质的组成，所述组合物包含单独或与渗透增强剂或混合物组合的待施用的百戈来替（治疗有效率）。 还公开了含有pergolide或pergolide和增强剂组合物的药物递送装置和透皮给药pergolide和pergolide /增强剂组合物的方法。