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公开(公告)号：EP0232580A2
公开(公告)日：1987-08-19
申请号：EP86306493.7
申请日：1986-08-21
申请人： ALZA CORPORATION
CPC分类号： A61K9/7053 , A61K9/0034 , A61K9/0041 , A61K9/7069 , Y10S424/14
摘要： A transdermal therapeutic system is provided which is adapted for delivery of a biologically active agent over an extended time period said system comprising a matrix containing an agent disposed therein, the intended body distal surface of said matric having fibrous reinforcing means embedded therein, said matrix being capable of firm adhesion to the skin but with a peel strength sufficiently low for removal without discomfort.
The reinforcing means comprises a stretchable fabric formed of either randomly or orientated bonded fibres to form an isotrophic web substantially equally deformable in all directions, or anisotrophic web formed of a multiplicity of continuous generally parallel fibres having randomly orientated second fibres bonded transversly thereto so as to be deformable primarily in a direction perpendicular to the continuous fibres.摘要翻译： 提供了经皮治疗系统，其适于在延长的时间段内递送生物活性剂，所述系统包含含有置于其中的药剂的基质，所述基质的预期身体远端表面具有嵌入其中的纤维增强装置，所述基质为 能够牢固地粘附到皮肤上，但具有足够低的剥离强度以便去除而不舒服。 增强装置包括由随机或取向的结合纤维形成的可拉伸织物，以形成在所有方向上基本上可等同变形的同质网，或由多个具有随机取向的第二纤维横向粘结的多个连续的大致平行的纤维形成的各向异性腹板，以便 可以主要在垂直于连续纤维的方向上变形。
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公开(公告)号：EP0232580B1
公开(公告)日：1992-11-04
申请号：EP86306493.7
申请日：1986-08-21
申请人： ALZA CORPORATION
CPC分类号： A61K9/7053 , A61K9/0034 , A61K9/0041 , A61K9/7069 , Y10S424/14
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公开(公告)号：EP0232580A3
公开(公告)日：1989-06-21
申请号：EP86306493.7
申请日：1986-08-21
申请人： ALZA CORPORATION
CPC分类号： A61K9/7053 , A61K9/0034 , A61K9/0041 , A61K9/7069 , Y10S424/14
摘要： A transdermal therapeutic system is provided which is adapted for delivery of a biologically active agent over an extended time period said system comprising a matrix containing an agent disposed therein, the intended body distal surface of said matric having fibrous reinforcing means embedded therein, said matrix being capable of firm adhesion to the skin but with a peel strength sufficiently low for removal without discomfort. The reinforcing means comprises a stretchable fabric formed of either randomly or orientated bonded fibres to form an isotrophic web substantially equally deformable in all directions, or anisotrophic web formed of a multiplicity of continuous generally parallel fibres having randomly orientated second fibres bonded transversly thereto so as to be deformable primarily in a direction perpendicular to the continuous fibres.
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