专利检索 ap:("Abbott Laboratories") AND inv:"SIUMMERS, James, B." 第 1 页

1.

发明公开
MACROCYCLIC INHIBITORS OF MATRIX METALLOPROTEINASES AND TNF$g(a) SECRETION 失效
标题翻译：基质金属蛋白酶和TNF-α分泌的大环INHIBITORE

公开(公告)号：EP1021423A1

公开(公告)日：2000-07-26

申请号：EP98901696.9

申请日：1998-01-07

申请人： Abbott Laboratories

发明人： DAVIDSEN, Steven, K. , STEINMAN, Douglas, H. , SHEPPARD, George, S. , XU, Lianhong , HOLMS, James, H. , GUO, Yan , FLORJANCIC, Alan, Scott , SIUMMERS, James, B. , MICHAELIDES, Michael, R.

IPC分类号： C07D267/00 , C07D225/06 , C07D245/02 , C07D245/06 , C07D255/02 , C07D413/04 , C07D413/06 , C07D417/06 , C07D487/08 , C07K5/078 , A61K31/55 , A61K38/05

CPC分类号： C07D413/04 , C07D225/06 , C07D245/02 , C07D245/06 , C07D267/00 , C07D413/06 , C07D417/06 , C07D487/08 , C07K5/06139

摘要： Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.