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1.发明公开
公开(公告)号：EP4373815A1
公开(公告)日：2024-05-29
申请号：EP22753972.3
申请日：2022-07-21
IPC分类号： C07D401/04 , C07D225/06 , A61P25/30 , C07D405/04 , C07D471/04
CPC分类号： C07D401/04 , C07D225/06 , C07D405/04 , C07D471/04 , A61P25/30
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公开(公告)号：EP3548455A1
公开(公告)日：2019-10-09
申请号：EP17878682.8
申请日：2017-12-05
IPC分类号： C07B63/00 , C07D207/02 , C07D225/06 , C07D277/22 , C07D307/26 , C07D307/32 , C07D307/38 , C07D493/02 , C07H19/01 , B01D15/10 , B01J39/02 , B01J20/00
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公开(公告)号：EP3481835A1
公开(公告)日：2019-05-15
申请号：EP17824731.8
申请日：2017-06-29
IPC分类号： C07D498/14 , C07D273/01 , C07D267/00 , C07D498/04 , C07D225/06 , C07D471/04 , C07D471/14 , C07D413/12 , A61K31/395 , A61K31/404 , A61K31/4164 , A61K31/435 , A61P35/00 , A61P17/00
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公开(公告)号：EP3237424A1
公开(公告)日：2017-11-01
申请号：EP15873802.1
申请日：2015-12-23
发明人： MORRA, Nicholas
IPC分类号： C07F5/02 , C07D225/06 , C07D403/12 , C07D403/10
CPC分类号： C07D225/06 , C07D403/12 , C07F5/025
摘要： The disclosure includes high purity compounds having CCR5 and/or CCR2 antagonism, or a salt thereof, and processes for synthesizing the same.
摘要翻译： 本公开内容包括具有CCR5和/或CCR2拮抗作用的高纯度化合物或其盐，及其合成方法。
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5.发明公开PROCESS FOR PREPARING CYCLIC CHIRAL AMINES AND ALCOHOLS BY INTRAMOLECULAR CATALYTIC ARYLATION OF BORONIC ACID OR ESTER ALDEHYDES AND IMINE SUBSTRATES 审中-公开用于生产循环手性胺和醇BY硼酸或-ESTERALDEHYDEN与亚胺底物分子内催化芳基化
公开(公告)号：EP3041824A1
公开(公告)日：2016-07-13
申请号：EP14772447.0
申请日：2014-09-01
发明人： BURKE, Anthony , SILVA MARQUES, Carolina , SILVA PEIXOTO, Daniela Alexandra , MATOS VIANA, Hugo Ricardo , BRITO GOTH, Albertino João
IPC分类号： C07D215/04 , C07D311/22 , C07D313/08 , C07D217/24 , C07D225/06
CPC分类号： C07D311/22 , C07D215/04 , C07D217/24 , C07D225/06 , C07D313/08
摘要： The present application provides a catalytic process which involves the cyclization of a novel catalytic intramolecular arylation process that involves boronic acid or ester aldehydes or imines substrates, of formula (I) and (II), to afford cyclic chiral alcohols or amines, of formula (VI) and (VII), respectably. The present application also describes the preparation of the substrates of formula (I) and (II) from simple commercial raw materials by efficient processes, some of which are catalytic.
摘要翻译： （本申请提供的催化过程，其中涉及一种新颖的催化的分子内的芳基化processthat的环化涉及到硼酸或酯的醛或式（I的亚胺基板）和（II），得到环状的手性醇或cardamines，式 VI）和（VII），体面。 因此，本申请描述了式（I）和（II）由高效的工艺简单的商业原料，其中一些是催化的基底的制备。
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公开(公告)号：EP1507773B1
公开(公告)日：2015-09-16
申请号：EP03721353.5
申请日：2003-03-07
发明人： BOIVIN, Roch , CHIBA, Kenichi , MURAMOTO, Kenzo , SHIROTA, Hiroshi , DU, Hong , EGUCHI, Yoshihito , FUJITA, Masanori , GUSOVSKY, Fabian , GOTO, Masaki , HARMANGE, Jean-Christophe , INOUE, Atsushi , JIANG, Yimin , KAWADA, Megumi , KAWAI, Takatoshi , KAWAKAMI, Yoshiyuki , KIMURA, Akifumi , KOTAKE, Makoto , KUBOI, Yoshikazu , LEMELIN, Charles-André , LI, Xiang-Yi , MATSUSHIMA, Tomohiro , MIZUI, Yoshiharu , SAKURAI, Hideki , CHOW, Jesse , SHEN, Yong-Chun , SPYVEE, Mark , TANAKA, Isao , WANG, John (Yuan) , YAMAMOTO, Satoshi , YONEDA, Naoki , KOBAYASHI, Seiichi
IPC分类号： C07D313/00 , A61K31/335 , A61P29/00 , C07D225/06 , C07D407/12 , C07D491/04 , C07D267/00 , C07D493/04 , A61K31/36 , A61K31/395 , A61P11/06 , A61P17/06 , A61P17/16 , A61P19/04 , A61P35/00 , A61P37/06
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R 1 -R 11 , t, X, Y, Z and n are as defined herein.
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7.发明授权Analogs of benzoquinone-containing ansamycins for the treatment of cancer 有权benzochinonhaltigen的安沙霉素类似物治疗癌症
公开(公告)号：EP1716119B1
公开(公告)日：2013-03-06
申请号：EP04817048.4
申请日：2004-12-23
发明人： ADAMS, Julian , GAO, Yun , GEORGES EVANGELINOS, Asimina, T , GRENIER, Louis , PAK, Roger, H , PORTER, James, R , WRIGHT, James, L
IPC分类号： C07D225/06 , C07D211/60 , C07D498/08 , C07F5/02 , A61K31/395 , A61P35/00
CPC分类号： A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
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公开(公告)号：EP1023315B1
公开(公告)日：2010-03-10
申请号：EP98923415.8
申请日：1998-05-14
发明人： ROSEN, Neal Office of Industrial Affairs , DANISHEVSKY, Samuel Office of Industrial Affairs , OUERFELLI, Ouathek Office of Industrial Affairs , KUDAK, Scott, D. Office of Industrial Affairs , SEPP-LORENZINO, Laura Office of Industrial Affairs
IPC分类号： C07J17/00 , C07J43/00 , C07D225/06 , C07D493/12 , A61K31/33 , A61K31/35 , A61K31/58
CPC分类号： C07D225/06 , A61K47/554 , C07J17/00 , C07J43/00
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9.发明公开METHOD OF TREATING MULTIPLE MYELOMA USING 17-AAG OR 17-AG OR A PRODRUG OF EITHER IN COMBINATION WITH A PROTEASOME INHIBITOR 审中-公开METHOD FOR多发性骨髓瘤的治疗中使用17-AAG或17-AG或前药或尤其是结合有蛋白酶体抑制剂
公开(公告)号：EP1874297A4
公开(公告)日：2009-04-22
申请号：EP06758739
申请日：2006-04-26
IPC分类号： A61K31/395 , A61K38/04 , A61P35/00 , C07D225/06
CPC分类号： C07D225/06 , A61K31/395 , A61K45/06 , A61K2300/00
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10.发明公开
公开(公告)号：EP1971578A1
公开(公告)日：2008-09-24
申请号：EP06820701.8
申请日：2006-12-22
发明人： MARTIN, Christine, Janet , WILKINSON, Barrie , GAISSER, Sabine , ZHANG, Ming-Qiang , SHERIDAN, Rose, Mary , SHEEHAN, Lesley Sarah , LILL, Rachel, Edith , NUR-E-ALAM, Mohammed , VOUSDEN, William, Alexander
IPC分类号： C07D225/06 , A61K31/395 , A61P35/00
CPC分类号： C07D225/06
摘要： The present invention relates to 21-deoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and / or prophylaxis of cancer or B-cell malignancies.
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