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    SUBSTITUTED DIAZABICYCLOHEPTANES AND THEIR USE AS PROTEIN KINASE INHIBITORS
    3.
    发明公开
    SUBSTITUTED DIAZABICYCLOHEPTANES AND THEIR USE AS PROTEIN KINASE INHIBITORS 审中-公开
    取代DIAZABICYCLOHEPTANE及其作为激酶抑制剂的蛋白质

    公开(公告)号：EP1727821A1

    公开(公告)日：2006-12-06

    申请号：EP05705583.2

    申请日：2005-01-12

    申请人： Amgen Inc.

    发明人： CAO, Guo-Qiang ,  CHEN, Jian, J. ,  DOMINGUEZ, Celia ,  REED, Anthony ,  SHAM, Kelvin, K., C. ,  THAMAN, Maya, C. ,  ZHANG, Dawei ,  HERBERICH, Bradley, J.

    IPC分类号： C07D487/08 ,  A61K31/4995 ,  A61P19/02

    CPC分类号： C07D487/06 ,  C07D213/56 ,  C07D239/95 ,  C07D401/04 ,  C07D401/14 ,  C07D417/14

    摘要： The present invention relates to therapeutic diazobicyclo pyridines and their use in the treatment of arthritis, rheumatoid arthritis, psoriatic arthritis or osteoarthritis, organ transplant, acute transplant or heterograft and homograft rejection, ischemic and reperfusion injury, transplantation tolerance induction, multiple sclerosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, lupus, graft vs. host diseases, T -cell mediated hypersensitivity diseases, contact hypersensitivity, delayed-type hypersensitivity, gluten-sensitive enteropathy, Type 1 diabetes, psoriasis, contact dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism,Graves' Disease, Addison's disease, autoimmune polyglandular disease, autoimmune alopecia, pernicious anemia, vitiligo, autoimmune hypopituatarism, Guillain-Barre syndrome, autoimmune diseases, glomerulonephritis, serum sickness, uticaria, respiratory allergies, asthma, hayfever, allergic rhinitis, skin allergies, scleracielma, mycosis fungoides, acute inflammatory responses, acute respiratory distress syndrome, dermatomyositis, alopecia areata, chronic actinic dermatitis, eczema, Behcet's disease, Pustulosis palmoplanteris, Pyoderma gangrenum, Sezary's syndrome, atopic dermatitis, systemic schlerosis, morphea, Type II diabetes and cancers where PKC theta or other PKC-family kinases are activated, overexpressed or facilitate tumor growth or survival of tumor cells, T cell leukemia, thymoma, T and B cell lymphoma, colon carcinoma, breast carcinoma and lung carcinoma or provides resistance to chemotherapeutic drugs.

    SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    6.
    发明公开
    SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE 审中-公开
    取代的杂环化合物和方法使用

    公开(公告)号：EP1506186A1

    公开(公告)日：2005-02-16

    申请号：EP03728971.7

    申请日：2003-05-15

    申请人： Amgen Inc.

    发明人： DOMINGUEZ, Celia ,  ZHANG, Dawei ,  CAO, Guo-Qiang ,  GOLDBERG, Martin, H. ,  HONG, Fang-Tsao ,  SHAM, Kelvin, K., C. ,  TADESSE, Seifu ,  TAMAYO, Nuria, A. ,  WEILER, Kurt, E. ,  LIAO, Hongyu

    IPC分类号： C07D401/04 ,  A61K31/444 ,  A61K31/513

    CPC分类号： C07D401/04

    摘要： The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein Rl is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R1 is additionally substituted; and R2 is a substituted C1-6balkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.