公开(公告)号：EP1506186A1

公开(公告)日：2005-02-16

申请号：EP03728971.7

申请日：2003-05-15

申请人： Amgen Inc.

发明人： DOMINGUEZ, Celia ,  ZHANG, Dawei ,  CAO, Guo-Qiang ,  GOLDBERG, Martin, H. ,  HONG, Fang-Tsao ,  SHAM, Kelvin, K., C. ,  TADESSE, Seifu ,  TAMAYO, Nuria, A. ,  WEILER, Kurt, E. ,  LIAO, Hongyu

IPC分类号： C07D401/04 ,  A61K31/444 ,  A61K31/513

CPC分类号： C07D401/04

摘要： The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein Rl is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R1 is additionally substituted; and R2 is a substituted C1-6balkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.