公开(公告)号：EP4029877A1

公开(公告)日：2022-07-20

申请号：EP21217086.4

申请日：2018-08-03

申请人： Amgen, Inc

发明人： ALI, Khaled, M.K.Z. ,  AGRAWAL, Neeraj, Jagdish ,  KANNAN, Gunasekaran ,  FOLTZ, Ian ,  WANG, Zhulun ,  BATES, Daren ,  MOCK, Marissa ,  TAKENAKA, Shunseke

IPC分类号： C07K14/54 ,  A61K47/60 ,  A61K47/54

摘要： Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.