公开(公告)号：EP4029877A1

公开(公告)日：2022-07-20

申请号：EP21217086.4

申请日：2018-08-03

申请人： Amgen, Inc

发明人： ALI, Khaled, M.K.Z. ,  AGRAWAL, Neeraj, Jagdish ,  KANNAN, Gunasekaran ,  FOLTZ, Ian ,  WANG, Zhulun ,  BATES, Daren ,  MOCK, Marissa ,  TAKENAKA, Shunseke

IPC分类号： C07K14/54 ,  A61K47/60 ,  A61K47/54

摘要： Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.

公开(公告)号：EP3737694A1

公开(公告)日：2020-11-18

申请号：EP19703451.5

申请日：2019-01-11

申请人： Amgen Inc.

发明人： ALI, Khaled, M.K.Z. ,  AGRAWAL, Neeraj, Jagdish ,  KANNAN, Gunasekaran ,  FOLTZ, Ian ,  WANG, Zhulun ,  BATES, Daren ,  MOCK, Marissa ,  TAKENAKA, Shunsuke

IPC分类号： C07K14/54 ,  A61K47/60 ,  A61K47/54 ,  C07K16/28

公开(公告)号：EP4067493A1

公开(公告)日：2022-10-05

申请号：EP22159835.2

申请日：2017-05-11

申请人： Amgen Inc.

发明人： MUNRO, Trent, P. ,  AGRAWAL, Neeraj, Jagdish ,  DARIS, Kristine, M.

IPC分类号： C12N15/65 ,  C12N15/67

摘要： This invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More specifically, the invention concerns improved selection of cells transfected with recombinantly engineered vectors designed to express polypeptides, in particular heteromultimeric polypeptides.