公开(公告)号：EP1590431A2

公开(公告)日：2005-11-02

申请号：EP04700833.9

申请日：2004-01-08

申请人： Applied Molecular Evolution, Inc.

发明人： WATKINS, Jeffry, D. ,  VASSEROT, Alain, P. ,  MARQUIS, David ,  HUSE, William, D.

IPC分类号： C12N1/00

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/525

摘要： The present invention relates to TNF-α binding molecules and nucleic acid sequences encoding TNF-α binding molecules. In particular, the present invention relates to TNF-α binding molecules with a high binding affinity, a high association rate, a low dissociation rate with regard to human TNF-α and that are capable of neutralizing TNF-α at low concentrations. Preferably, the TNF-α binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).