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公开(公告)号：EP1633396B1
公开(公告)日：2011-07-27
申请号：EP04752743.7
申请日：2004-05-20
CPC分类号： C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The present invention relates to CD20 binding molecules and nucleic acid sequences encoding CD20 binding molecules. In particular, the present invention relates to CD20 binding molecules with a high binding affinity, and a low dissociation rate, with regard to human CD20. Preferably, the CD20 binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).
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公开(公告)号：EP2341075A1
公开(公告)日：2011-07-06
申请号：EP10010678.0
申请日：2001-03-01
发明人： Young, James F. , Koenig, Scott , Johnson, Leslie S. , Huse, William D. , Wu, Herren , Watkins, Jeffry D.
IPC分类号： C07K16/00 , C07K16/10 , A61K39/395 , A61P31/00
CPC分类号： C07K16/1027 , A61K2039/505 , C07K16/00 , C07K2317/567
摘要： High potency antibodies, including immunologically active fragments thereof, having high kinetic association rate constants and optional high affinities are disclosed, along with methods for producing such antibodies. The high potency antibodies disclosed herein are neutralizing or non-neutralizing type and have specificity for antigens displayed by microorganisms, especially viruses as well as antigenic sites present on cancer cells and on various types of toxins, and the products of toxins. Processes for production of high potency neutralizing antibodies and increasing the potency of already existing neutralizing antibodies are also described. Methods of using said antibodies in the prevention and/or treatment of diseases, especially diseases induced or caused by viruses, are disclosed.
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公开(公告)号：EP1853630A1
公开(公告)日：2007-11-14
申请号：EP04794210.7
申请日：2004-10-28
发明人： WATKINS, Jeffry, Dean , HUSE, William, D. , VASSEROT, Alain, Philippe , MARQUIS, David , SMITH, Eric Michael
CPC分类号： C07K16/2878 , C07K16/36 , C07K16/464 , C07K16/465 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/92
摘要： The present invention provides optimized heteromeric variable region binding fragments and antibodies comprising optimized heteromeric variable region binding fragments. Preferably, the optimized heteromeric variable region binding fragments exhibit optimized activity compared to donor heteromeric variable regions and have unvaried human frameworks. The present invention also provides methods of making the optimized heteromeric variable region binding fragments.
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公开(公告)号：EP1776384A2
公开(公告)日：2007-04-25
申请号：EP05773014.5
申请日：2005-07-18
IPC分类号： C07K16/00 , C12N15/12 , C12N5/10 , A61K39/395
CPC分类号： C07K16/2887 , C07K16/2896 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The present invention provides polypeptides, particularly therapeutic antibodies, comprising a novel, variant Fc region. Furthermore the invention provides variant Fc regions which confer an altered effector function or altered serum half life upon a polypeptide to which it is operable attached.
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5.发明公开BUTYRYLCHOLINESTERASE VARIANT POLYPEPTIDES WITH INCREASED CATALYTIC EFFICIENCY AND METHODS OF USE 审中-公开丁酰胆碱酯酶VARIANT多肽，增加的催化效率和ANWENDUNGSVERFHAREN
公开(公告)号：EP1622638A2
公开(公告)日：2006-02-08
申请号：EP04759449.4
申请日：2004-04-09
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01008
摘要： The invention provides a butyrylcholinesterase variant having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acid. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition with the invention variant.
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6.发明公开BUTYRYLCHOLINESTERASE POLYPEPTIDE VARIANTS WITH INCREASED CATALYTIC EFFICIENCY AND METHODS OF USE 审中-公开BUTYRYLCHOLINESTERASEPOLYPEPTIDVARIANTEN具有较高的催化效率及其用途
公开(公告)号：EP1414974A2
公开(公告)日：2004-05-06
申请号：EP01997137.3
申请日：2001-12-21
CPC分类号： C12Q1/46 , A61K38/00 , C12N9/18 , C12Y301/01008
摘要： The invention provides twenty-five butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries of butyrylcholinesterase variants as well as libraries of the corresponding nucleic acids encoding butyrylcholinesterase variants. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
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公开(公告)号：EP1874351B1
公开(公告)日：2015-04-08
申请号：EP06751915.7
申请日：2006-04-28
发明人： CHEN, Yan , GARDNER, Debra , KNIGHT, David, M. , LARK, Michael, W. , LIANG, Bailin , SHEALY, David, J. , SONG, Xiao-Yu, R. , STOJANOVIC-SUSULIC, Vedrana , SWEET, Raymond, W. , TAM, Susan, H. , WU, Sheng-Jiun , YANG, Jing , MARQUIS, David, Matthew , SMITH, Eric, Michael , VASSEROT, Alain, Philippe
IPC分类号： C12N5/10 , C12N15/12 , C12N15/13 , C12N15/63 , A61K39/395 , G01N33/53 , G01N33/567 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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公开(公告)号：EP2154157A3
公开(公告)日：2010-04-28
申请号：EP09155531.8
申请日：2005-01-10
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/2896 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/732 , C07K2317/734
摘要： The present invention provides polypeptide Fc region variants and oligonucleotides encoding Fc region variants. Specifically, the present invention provides compositions comprising novel Fc region variants, methods for identifying useful Fc region variants, and methods for employing Fc region variants for treating disease.
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公开(公告)号：EP1590431A2
公开(公告)日：2005-11-02
申请号：EP04700833.9
申请日：2004-01-08
IPC分类号： C12N1/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N2333/525
摘要： The present invention relates to TNF-α binding molecules and nucleic acid sequences encoding TNF-α binding molecules. In particular, the present invention relates to TNF-α binding molecules with a high binding affinity, a high association rate, a low dissociation rate with regard to human TNF-α and that are capable of neutralizing TNF-α at low concentrations. Preferably, the TNF-α binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).
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10.发明公开BUTYRYLCHOLINESTERASE VARIANTS THAT ALTER THE ACTIVITY OF CHEMOTHERAPEUTIC AGENTS 审中-公开酶活性的影响化疗药物CHANGING丁酰胆碱酯酶变异
公开(公告)号：EP1581253A2
公开(公告)日：2005-10-05
申请号：EP03796682.7
申请日：2003-12-04
摘要： The invention provides a butyrylchinesterase variant, a method of converting a camptothecin derivative to a topoisomerase inhibitor by contacting the camptothecin derivative with a butyrylcholinesterase variant and a method of treating cancer by administering to an individual an effective amount a butyrylcholinesterase variant exhibiting increased capability to convert a camptothecin derivative to a topoisomerase inhibitor compared to butyrylcholinesterase.
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