公开(公告)号：EP1047426B1

公开(公告)日：2010-05-12

申请号：EP98957573.3

申请日：1998-11-03

申请人： Arch Development Corporation ,  UR LABS, INC.

发明人： DRELL, William ,  FOSS, Joseph, F. ,  ROIZEN, Michael, F. ,  MOSS, Jonathan ,  YUAN, Chun-Su

IPC分类号： A61K31/485 ,  A61P1/00

CPC分类号： A61K31/485

公开(公告)号：EP1047426A1

公开(公告)日：2000-11-02

申请号：EP98957573.3

申请日：1998-11-03

申请人： Arch Development Corporation

发明人： DRELL, William ,  FOSS, Joseph, F. ,  ROIZEN, Michael, F. ,  MOSS, Jonathan ,  YUAN, Chun-Su

IPC分类号： A61K31/485

CPC分类号： A61K31/485

摘要： A method for preventing or treating opioid induced side effects including dysphoria, pruritus, urinary retention and gastrointestinal dysfunction and non-opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered by the route selected from the group consisting of intravenous, intramuscular, transmucosal, transdermal, and oral administration, preferably administered orally in an enterically coated form.