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1.发明公开Cancer treatments by using a combination of an antibody against her2 and interleukin-2 审中-公开通过使用针对her2和白细胞介素-2的抗体的组合进行癌症治疗
公开(公告)号：EP1935431A3
公开(公告)日：2008-08-13
申请号：EP08002125.6
申请日：2001-05-15
IPC分类号： A61K39/395 , A61K38/20 , A61P35/00
CPC分类号： C07K16/32 , A61K38/2013 , A61K39/39558 , A61K2039/505 , A61K2039/545 , A61K2300/00
摘要： Methods for treating a subject with a cancer that is characterized by overexpression of HER2 receptor protein using a combination of interleukin-2 (IL-2) or variant thereof and at least one anti-HER2 antibody or fragment thereof are provided.
These anti-tumor agents are administered as two separate pharmaceutical compositions, one containing IL-2 (or variant thereof), the other containing at least one anti-HER2 antibody (or fragment thereof), according to a dosing regimen. Administering of these two agents together potentiates the effectiveness of the anti-HER2 antibody alone, resulting in a positive therapeutic response that is improved with respect to that observed with this anti-tumor agent.摘要翻译： 提供了使用白细胞介素-2（IL-2）或其变体和至少一种抗HER2抗体或其片段的组合来治疗患有以过表达HER2受体蛋白为特征的癌症的受试者的方法。 根据给药方案，这些抗肿瘤剂作为两种独立的药物组合物施用，一种含有IL-2（或其变体），另一种含有至少一种抗HER2抗体（或其片段）。 一起施用这两种药物加强了单独的抗HER2抗体的有效性，导致相对于用该抗肿瘤剂观察到的改善的阳性治疗反应。
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公开(公告)号：EP1007890B1
公开(公告)日：2007-10-24
申请号：EP98936007.8
申请日：1998-07-24
发明人： WINSTON, Roland , RIES, Harald
摘要： A non-imaging optical system for operating on light using broken symmetry reflector surfaces (30). The theoretical upper limit for concentration of direct solar radiation at low latitudes with stationary concentrators is determined from the projected solid angle sampled by the apparent motion of the sun. Based on the fact that the solar radiation is not uniformly distributed within this projected solid angle, we derive higher concentrations which apply when rejecting the lower density radiation. Trough type systems, which have translational symmetry, cannot be ideal stationary concentrators. Efficiency is improved by using broken symmetry for surfaces of the reflector (30) and the light source or concentrator. We note that what applies to concentrators applies equally to reflectors for illumination.
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公开(公告)号：EP1055239B8
公开(公告)日：2006-06-07
申请号：EP99903131.3
申请日：1999-01-14
摘要： A method and apparatus for monitoring a source of data for determining an operating state of a working system. The method includes determining a sensor (or source of data) arrangement associated with monitoring the source of data for a system, activating a method for performing a sequential probability ratio test if the data source includes a single data (sensor) source, activating a second method for performing a regression sequential possibility ratio testing procedure if the arrangement includes a pair of sensors (data sources) with signals which are linearly of non-linearly related; activating a third method for performing a bounded angle ratio test procedure if the sensor arrangement includes multiple sensors and utilizing at least one of the first, second and third methods to accumulate sensor signals and determining the operating state of the system.
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4.发明授权MUTATIONS IN THE DIABETES SUSCEPTIBILITY GENES HEPATOCYTE NUCLEAR FACTOR (HNF) HNF-1ALPHA, HNF-1BETA AND HNF-4ALPHA 无效易感基因突变WITHIN肝细胞关键因子（HNF）HNF-1α，HNF-1β和HNF-4alpha糖尿病
公开(公告)号：EP0920534B1
公开(公告)日：2005-12-28
申请号：EP97941508.0
申请日：1997-09-10
发明人： BELL, Graeme, I. , YAMAGATA, Kazuya Second Dept.of InternalMedicine , ODA, Naohisa , KAISAKI, Pamela, J. , FURUTA, Hiroto The First Department of Medicine , MENZEL, Stephan , HORIKAWA, Yukio
CPC分类号： C07K14/4702 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
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5.发明授权
公开(公告)号：EP1019524B1
公开(公告)日：2004-09-29
申请号：EP98903847.6
申请日：1998-01-30
发明人： ROIZMAN, Bernard , BIN, He
IPC分类号： C12Q1/00
CPC分类号： C12Q1/42 , G01N2333/912 , G01N2333/916
摘要： Methods for identifying inducers and inhibitors of programmed cell death in a cell-free system are described. The methods exploit the finding that programmed cell death is accompanied by shutdown of cellular protein synthesis and by phosphorylation of eIF-2 alpha and that the dephosphorylation of eIF-2 alpha prevents the shutdown of protein synthesis.
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6.发明授权
公开(公告)号：EP0986401B1
公开(公告)日：2004-02-25
申请号：EP98937941.7
申请日：1998-05-29
CPC分类号： A61K31/702 , A61K41/00 , A61K48/00
摘要： The present invention relates to the use of P-selectin as a targeting agent in radiotherapies for vascular related disease. P-selectin is translocated to the lume of vascular endothelia as a result of radiation. Thus, P-selecting provides a target for receptor-mediated delivery of drugs, including anticancer drugs and drugs for the treatment of vascular disease. However, P-selectin also plays a role in the activation of certain inflammatory cells and, as such, plays a role in radiation-induced inflammation. By interfering with P-selectin induction of inflammation, it is possible to modulate inflammatory responses to radiation therapy.
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7.发明公开Methods for Modulating T-Cell Survival by Modulating BCL-XL Protein Level 失效Verfahren zur Inhibierung der T-Zell-Ueberlebensrate durch Inhibierung des BCL-XL Protein-Spiegels
公开(公告)号：EP1384781A1
公开(公告)日：2004-01-28
申请号：EP03014974.4
申请日：1996-05-02
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE NAVY , ARCH DEVELOPMENT CORPORATION
发明人： June, Carl H. , Thompson, Craig B.
CPC分类号： C07K14/4747 , A61K38/00
摘要： Methods for protecting a T cell from cell death are described. The methods involve contacting the T cell with an agent which augments the bcl-X L protein level in the T cell such that it is protected from cell death. The invention further pertains to methods for increasing the susceptibility of a T cell to cell death, comprising contacting the T cell with at least one agent which decreases bcl-X L protein level in the T cell. Both in vivo and in vitro methods are described.
摘要翻译： 描述了保护T细胞免于细胞死亡的方法。 所述方法包括使T细胞与增加T细胞中bcl-XL蛋白水平的试剂接触，使其免于细胞死亡。 本发明还涉及增加T细胞对细胞死亡的易感性的方法，包括使T细胞与降低T细胞中bcl-XL蛋白水平的至少一种试剂接触。 描述体内和体外方法。
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8.发明公开METHOD, SYSTEM AND COMPUTER READABLE MEDIUM FOR THE TWO-DIMENSIONAL AND THREE-DIMENSIONAL DETECTION OF LUNGS NODULES IN COMPUTED TOMOGRAPHY SCANS 审中-公开方法，系统和计算机可读介质在CAT扫描样品LUNGENNODULEN的二维和三维检测
公开(公告)号：EP1249006A1
公开(公告)日：2002-10-16
申请号：EP01942767.3
申请日：2001-01-18
IPC分类号： G06T5/00
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/174 , G06T7/187 , G06T2207/10081 , G06T2207/10124 , G06T2207/20061 , G06T2207/30064
摘要： A method, system and computer readable medium for automated detection of lung nodules in computed tomography (CT) image scans, including generating two-dimensional segmented lung images by segmenting a plurality of two-dimensional CT image sections derived from the CT image scans; generating three-dimensional segmented lung volume images by combining the two-dimensional segmented lung images; determining three-dimensional lung nodule candidates from the three-dimensional segmented lung volume images, including, identifying structures within the three-dimensional segmented lung volume images that meet a volume criterion; deriving features from the lung nodule candidates; and detecting lung nodules by analyzing the features to eliminate false-positive nodule candidates from the nodule candidates.
摘要翻译： 的方法，系统以及用于在计算机断层摄影（CT）图像扫描肺结节自动检测，包括通过分割从CT图像扫描得到的二维CT图像部分的多个发电二维分割肺部图像的计算机可读介质; 生成通过组合二维分割肺部图像三维分段肺容积图像; 从三维分段肺容积图像确定三维肺结节候选，包括满足一个标准体积的三维分段肺体积图像内识别结构; 导出来自肺结节候选特征; 并通过分析功能，以消除结节候选人的假阳性结节候选检测肺结节。
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公开(公告)号：EP0675801B1
公开(公告)日：2002-04-03
申请号：EP94903643.8
申请日：1993-12-10
IPC分类号： A01N41/02
CPC分类号： A01N41/02 , Y10S428/907 , Y10T428/23 , Y10T428/31504 , Y10T428/8305
摘要： p-sulfoxy cinnamic acid isolated from methanolic extracts of the eelgrass Zostera marina having significant antifouling aquatic properties. p-sulfoxy cinnamic acid was synthesized in the laboratory from p-coumaric acid, and antifouling activity was identical to the natural compound in laboratory bioassays. In addition, sulfate esters of other phenolic acids showed similar antifouling activity, suggesting that the sulfate ester was responsible for the antifouling effect.
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10.发明公开METHOD AND SYSTEM FOR THE ASSESSMENT OF TUMOR EXTENT IN MAGNETIC RESONANCE IMAGES 审中-公开方法和装置用于评估肿瘤在磁场中IMAGES度
公开(公告)号：EP1113752A1
公开(公告)日：2001-07-11
申请号：EP99946877.0
申请日：1999-09-15
发明人： GILHUIJS, Kenneth-University of Chicago , GIGER, Maryellen, L. , BICK, Ulrich-University of Chicago
IPC分类号： A61B6/00
CPC分类号： G06T7/11 , G06T2207/10088 , G06T2207/30068 , G06T2207/30096
摘要： A method, computer program product, and system for assessing tumor extent in medical temporally acquired images. An image acquisition unit (2) may acquire images, and converts the breast images into digital images. A breast volume segmentation unit (6) performs volume segmentation on the images obtained by the image acquisition unit (2), and a border removal unit (8) performs breast border removal based on data generated by the volume segmentation unit (6). A lesion enhancement unit (10) performs lesion enhancement for image data generated by the volume segmentation unit (6). A bounding unit (12) determines a bounding sphere based on the image data generated by the lesion enhancement unit (10), and a three-dimensional search volume unit (14) determines a three-dimensional search volume within the image data generated by the bounding unit (12). A suppression unit (16) suppresses surrounding structures in the image data generated by the three-dimensional search unit.
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