公开(公告)号：EP4086286A1

公开(公告)日：2022-11-09

申请号：EP22168997.9

申请日：2018-05-11

申请人： Argenx BV ,  Université Catholique de Louvain

发明人： VAN DER WONING, Sebastian ,  BORGIONS, Filip ,  DREIER, Torsten ,  MARIËN, Lore ,  DE BOECK, Gitte ,  LIENART, Stéphanie ,  LUCAS, Sophie ,  COULIE, Pierre

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K39/00

摘要： The present disclosure relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-β1, particularly a complex of human GARP and human TGF-β1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-β from regulatory T cells. The antibodies and antigen binding fragments of the present disclosure are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.

公开(公告)号：EP4282430A3

公开(公告)日：2024-04-03

申请号：EP23189977.4

申请日：2018-05-11

申请人： Argenx BV ,  Université catholique de Louvain

发明人： VAN DER WONING, Sebastian ,  BORGIONS, Filip ,  DREIER, Torsten ,  MARIËN, Lore ,  DE BOECK, Gitte ,  LIENART, Stéphanie ,  LUCAS, Sophie ,  COULIE, Pierre

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K39/00

摘要： The present invention relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-β1, particularly a complex of human GARP and human TGF-β1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-β from regulatory T cells. The antibodies and antigen binding fragments of the present invention are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.

公开(公告)号：EP4282430A2

公开(公告)日：2023-11-29

申请号：EP23189977.4

申请日：2018-05-11

申请人： Argenx BV ,  Université catholique de Louvain

发明人： VAN DER WONING, Sebastian ,  BORGIONS, Filip ,  DREIER, Torsten ,  MARIËN, Lore ,  DE BOECK, Gitte ,  LIENART, Stéphanie ,  LUCAS, Sophie ,  COULIE, Pierre

IPC分类号： A61K39/395

摘要： The present invention relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-β1, particularly a complex of human GARP and human TGF-β1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-β from regulatory T cells. The antibodies and antigen binding fragments of the present invention are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.

公开(公告)号：EP3606961A1

公开(公告)日：2020-02-12

申请号：EP18728524.2

申请日：2018-05-11

申请人： Argenx BVBA ,  Université Catholique de Louvain

发明人： VAN DER WONING, Sebastian ,  BORGIONS, Filip ,  DREIER, Torsten ,  MARIËN, Lore ,  DE BOECK, Gitte ,  LIENART, Stéphanie ,  LUCAS, Sophie ,  COULIE, Pierre

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K39/00