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公开(公告)号：EP4086286A1
公开(公告)日：2022-11-09
申请号：EP22168997.9
申请日：2018-05-11
发明人： VAN DER WONING, Sebastian , BORGIONS, Filip , DREIER, Torsten , MARIËN, Lore , DE BOECK, Gitte , LIENART, Stéphanie , LUCAS, Sophie , COULIE, Pierre
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： The present disclosure relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-β1, particularly a complex of human GARP and human TGF-β1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-β from regulatory T cells. The antibodies and antigen binding fragments of the present disclosure are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.
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公开(公告)号：EP4282430A3
公开(公告)日：2024-04-03
申请号：EP23189977.4
申请日：2018-05-11
发明人： VAN DER WONING, Sebastian , BORGIONS, Filip , DREIER, Torsten , MARIËN, Lore , DE BOECK, Gitte , LIENART, Stéphanie , LUCAS, Sophie , COULIE, Pierre
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
摘要： The present invention relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-β1, particularly a complex of human GARP and human TGF-β1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-β from regulatory T cells. The antibodies and antigen binding fragments of the present invention are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.
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公开(公告)号：EP4282430A2
公开(公告)日：2023-11-29
申请号：EP23189977.4
申请日：2018-05-11
发明人： VAN DER WONING, Sebastian , BORGIONS, Filip , DREIER, Torsten , MARIËN, Lore , DE BOECK, Gitte , LIENART, Stéphanie , LUCAS, Sophie , COULIE, Pierre
IPC分类号： A61K39/395
摘要： The present invention relates to antibodies and antigen binding fragments thereof, which bind to a complex of GARP and TGF-β1, particularly a complex of human GARP and human TGF-β1. These antibodies and antigen binding fragments exhibit a combination of advantageous properties including high affinity antigen binding and the ability to inhibit the release of active TGF-β from regulatory T cells. The antibodies and antigen binding fragments of the present invention are relatively resistant to deamidation, isomerization and oxidation, such that they display improved stability.
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公开(公告)号：EP3606961A1
公开(公告)日：2020-02-12
申请号：EP18728524.2
申请日：2018-05-11
发明人： VAN DER WONING, Sebastian , BORGIONS, Filip , DREIER, Torsten , MARIËN, Lore , DE BOECK, Gitte , LIENART, Stéphanie , LUCAS, Sophie , COULIE, Pierre
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00
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5.发明公开
公开(公告)号：EP3786187A1
公开(公告)日：2021-03-03
申请号：EP20201515.2
申请日：2014-08-01
发明人： LUCAS, Sophie , COULIE, Pierre , CUENDE VILLASUR, Julia , DUMOUTIER, Laure , RENAULD, Jean-Christophe , VAN DER WONING, Sebastian , SAUNDERS, Michael , DE HAARD, Hans , DE BOECK, Gitte
摘要： The present invention relates to a protein binding to GARP in the presence of TGF-β and uses thereof.
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公开(公告)号：EP3253796A1
公开(公告)日：2017-12-13
申请号：EP16710325.8
申请日：2016-02-02
发明人： SAUNDERS, Michael , COULIE, Pierre , LUCAS, Sophie , DE BOECK, Gitte , VAN DE WONING, Sebastian , DE HAARD, Hans
IPC分类号： C07K16/28 , C07K16/22 , A61K39/395 , A61P37/02
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/2863 , C07K2317/22 , C07K2317/32 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： The present disclosure relates to a protein binding to GARP in the presence of TGF-β and uses thereof.
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公开(公告)号：EP3027650A1
公开(公告)日：2016-06-08
申请号：EP14748185.7
申请日：2014-08-01
发明人： LUCAS, Sophie , COULIE, Pierre , CUENDE VILLASUR, Julia , DUMOUTIER, Laure , RENAULD, Jean-Christophe , VAN DE WONING, Sebastian , SAUNDERS, Michael , DE HAARD, Hans , DE BOECK, Gitte
CPC分类号： C07K16/2875 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to an antibody binding to the transmembrane protein ‘glycoprotein A repetitions predominant’ (GARP) in the presence of TGF-β and uses thereof.
摘要翻译： 本发明涉及在TGF-β存在下与跨膜蛋白“重复占优势”（GARP）结合的抗体及其用途。
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