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1.发明公开CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS 有权化合物637：PYRIDOPYRIMIDINDIONE作为PDE4抑制剂的
公开(公告)号：EP2106396A2
公开(公告)日：2009-10-07
申请号：EP08700158.2
申请日：2008-01-10
申请人： AstraZeneca AB
发明人： BONNERT, Roger, Victor , BURKAMP, Frank , COX, Rhona, Jane , DE SOUSA, Simon , DICKINSON, Mark , HUNT, Simon, Fraser , MEGHANI, Premji , PIMM, Austen , SANGANEE, Hitesh, Jayantilal
IPC分类号： C07D213/80 , C07D401/12 , C07D471/04 , C07D471/08 , C07D519/00 , A61K31/519 , A61P11/06
CPC分类号： C07D519/00 , C07D213/80 , C07D401/12 , C07D471/04 , C07D471/08
摘要： The present invention provides a compound of a formula (I), wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE4 mediated disease state.
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2.发明公开STEROIDAL [3, 2-C]PYRAZOLE COMPOUNDS, WITH GLUCOCORTICOID ACTIVITY 审中-公开STEROIDALE [3,2-C] PYRAZOLVERBINDUNGEN MITGLUCOCORTICOIDAKTIVITÄT
公开(公告)号：EP2207788A1
公开(公告)日：2010-07-21
申请号：EP08806706.1
申请日：2008-10-02
申请人： AstraZeneca AB
发明人： BLADH, Håkan , BURKAMP, Frank , GABOS, Balint , HANSEN, Peter , IVANOVA, Svetlana , LAWITZ, Karolina
CPC分类号： C07J71/0047
摘要： The present invention provides compounds of formula (I) wherein n, p, R1, R2, X1, X2, X3, X4, X5, R3a, R3b, R4, R5 and R6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.
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3.发明公开16 ALPHA, 17 ALPA-ACETAL GLUCOCORTICOSTEROIDAL DERIVATIVES AND THEIR USE 审中-公开16 ALPHA，17 ALPA缩醛糖皮质激素衍生物及其
公开(公告)号：EP2257568A1
公开(公告)日：2010-12-08
申请号：EP09714543.7
申请日：2009-02-27
申请人： AstraZeneca AB
发明人： BURKAMP, Frank , MUSSIE, Tesfaledet , BHATTACHARYYA, Sumita , BLADH, Håkan , IVANOVA, Svetlana , LEPISTÖ, Matti
CPC分类号： C07J71/00
摘要： The present invention provides compounds of formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 and R
6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.-
公开(公告)号：EP2624838A1
公开(公告)日：2013-08-14
申请号：EP11781829.4
申请日：2011-10-05
申请人： AstraZeneca AB
CPC分类号： A61K45/06 , A61K9/0075 , A61K31/44 , A61K31/58 , A61K2300/00
摘要： The invention provides a pharmaceutical product comprising, in combination, (1) a named glucocorticosteroid receptor agonist and (2) a β
2 adrenoreceptor agonist, a dual β
2 adrenoreceptor agonist/M
3 receptor antagonist, a muscarinic antagonist, a p38 kinase inhibitor, a neutrophil elastase inhibitor, a phosphodiesterase PDE4 inhibitor, an IKK2 kinase inhibitor or a non-steroidal glucocorticoid receptor agonist, and the use of said product in treating respiratory diseases.-
5.发明公开NOVEL DERIVATIVES OF STEROIDALÝ3,2-C¨PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY 有权具有糖皮质激素活性的类甾体3,2-吡唑类化合物的新衍生物
公开(公告)号：EP2414377A1
公开(公告)日：2012-02-08
申请号：EP10759128.1
申请日：2010-04-01
申请人： AstraZeneca AB
发明人： BLADH, Håkan , BURKAMP, Frank , GABOS, Balint , HANSEN, Peter
CPC分类号： A61K31/58 , C07J71/0047
摘要： The present invention provides named compounds of formula (I), and pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供了命名的式（I）化合物和含有它们的药物组合物及其在治疗中的用途。
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6.发明公开NOVEL AMIDE DERIVATIVES OF STEROIDALÝ3,2-C¨PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY 审中-公开具有糖皮质激素活性的甾体2,3,2-吡唑类化合物的新酰胺衍生物
公开(公告)号：EP2414375A1
公开(公告)日：2012-02-08
申请号：EP10759125.7
申请日：2010-03-31
申请人： AstraZeneca AB
CPC分类号： C07J71/0047 , A61K31/58
摘要： The present invention provides compounds of formula (I) wherein n, R
1 , R
2 , X
1 , X
2 , X
3 , X
4, X
5 , R
3a , R
3b , R
4 , R
5 and R
6 are defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.摘要翻译： 本发明提供了式（I）的化合物，其中n，R 1，R 2，X 1，X 2，X 3，X 4，X 5，R 3a，R 3b，R 4，R 5和R 6被定义 在说明书中，它们的制备方法，含有它们的药物组合物以及它们在治疗中的用途。
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7.发明授权NOVEL DERIVATIVES OF STEROIDAL [3,2-C] PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY 有权具有糖皮质激素活性的甾体[3,2-C]吡唑类化合物的新衍生物
公开(公告)号：EP2414377B1
公开(公告)日：2016-01-06
申请号：EP10759128.1
申请日：2010-04-01
申请人： AstraZeneca AB
发明人： BLADH, Håkan , BURKAMP, Frank , GABOS, Balint , HANSEN, Peter
CPC分类号： A61K31/58 , C07J71/0047
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8.发明公开PHARMACEUTICAL COMPOSITION COMPRISING A STEROIDAL[3,2-C]PYRAZOLE DERIVATIVE AND A SECOND PHARMACEUTICALLY ACTIVE COMPOUND 审中-公开PHARMACEUTICAL相关的甾体并[3,2-c]吡唑和第二活性MARKETING
公开(公告)号：EP2414376A1
公开(公告)日：2012-02-08
申请号：EP10759126.5
申请日：2010-03-31
申请人： AstraZeneca AB
发明人： BURKAMP, Frank , HANSEN, Peter
CPC分类号： A61K45/06 , A61K9/0075 , A61K31/58 , A61K2300/00
摘要： The invention provides a pharmaceutical product comprising, in combination, (1 ) (1 R,3aS,3bS,1 OaR, 10bS, 11 S,12aS)1-{[(cyanomethyl)sulfanyl]carbonyl}-7-(4-fluorophenyl)- 1 1 -hydroxy-10a,12a-dimethyl-1,2,3,3a,3b, 4,5,7,10,10a, 10b, 1 1,12,12a- tetradecahydrocyclopenta[1,2-f]indazol-1 -yl furan-2-carboxylat and (2) a 'beta'2 adrenoreceptor agonist, a dual 'beta'2 adrenoreceptor agonist/M3 receptor antagonist or a muscarinic antagonist, and the use of said product in treating respiratory diseases.
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