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1.发明公开CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS 有权化合物637：PYRIDOPYRIMIDINDIONE作为PDE4抑制剂的
公开(公告)号：EP2106396A2
公开(公告)日：2009-10-07
申请号：EP08700158.2
申请日：2008-01-10
申请人： AstraZeneca AB
发明人： BONNERT, Roger, Victor , BURKAMP, Frank , COX, Rhona, Jane , DE SOUSA, Simon , DICKINSON, Mark , HUNT, Simon, Fraser , MEGHANI, Premji , PIMM, Austen , SANGANEE, Hitesh, Jayantilal
IPC分类号： C07D213/80 , C07D401/12 , C07D471/04 , C07D471/08 , C07D519/00 , A61K31/519 , A61P11/06
CPC分类号： C07D519/00 , C07D213/80 , C07D401/12 , C07D471/04 , C07D471/08
摘要： The present invention provides a compound of a formula (I), wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE4 mediated disease state.
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2.发明授权PHENOXYPYRIDINYLAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PDE4 MEDIATED DISEASE STATES 有权PHENOXYPYRIDINYLAMIDDERIVATE及其使用PDE4介导的疾病状态的治疗
公开(公告)号：EP2297106B1
公开(公告)日：2014-07-16
申请号：EP09754139.5
申请日：2009-05-26
申请人： AstraZeneca AB
发明人： ANDREWS, Glen , COX, Rhona, Jane , DE SAVI, Christopher , MEGHANI, Premji , SANGANEE, Hitesh, Jayantilal , WARNER, Daniel, Jon
IPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/455 , A61P25/00 , A61P9/00 , A61P37/00 , A61P35/00
CPC分类号： C07D471/04 , C07D213/82 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D498/04
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3.发明授权PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS 有权趋化因子受体的PYRIMIDINSULFONAMIDDERIVATE AS调节剂
公开(公告)号：EP1809624B1
公开(公告)日：2013-11-20
申请号：EP05773278.6
申请日：2005-08-23
申请人： AstraZeneca AB
发明人： CHESHIRE, David, Ranulf , COX, Rhona, Jane , MEGHANI, Premji , PRESTON, Cherylin, Francis , SMITH, Neal, Michael , STONEHOUSE, Jeffrey, Paul
IPC分类号： C07D403/12 , C07D417/12 , C07D401/12 , A61K31/5377
CPC分类号： C07D405/14 , C07D405/12
摘要： The compound 4-chloro-2-[(2,3-difluorobenzyl)thio]-6-{(1R)-I-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethoxy}pyrimidine.
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4.发明公开PHENOXYPYRIDINYLAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PDE4 MEDIATED DISEASE STATES 有权PHENOXYPYRIDINYLAMIDDERIVATE及其使用PDE4介导的疾病状态的治疗
公开(公告)号：EP2297106A1
公开(公告)日：2011-03-23
申请号：EP09754139.5
申请日：2009-05-26
申请人： AstraZeneca AB
发明人： ANDREWS, Glen , COX, Rhona, Jane , DE SAVI, Christopher , MEGHANI, Premji , SANGANEE, Hitesh, Jayantilal , WARNER, Daniel, Jon
IPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/455 , A61P25/00 , A61P9/00 , A61P37/00 , A61P35/00
CPC分类号： C07D471/04 , C07D213/82 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D498/04
摘要： The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE4 mediated disease state.
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