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    VERFAHREN ZUR HERSTELLUNG VON SULFONAMIDEN
    1.
    发明公开
    VERFAHREN ZUR HERSTELLUNG VON SULFONAMIDEN 审中-公开

    公开(公告)号：EP1957443A2

    公开(公告)日：2008-08-20

    申请号：EP06830101.9

    申请日：2006-11-23

    申请人： BASF SE

    发明人： SCHMIDT, Thomas ,  GEBHARDT, Joachim ,  LÖHR, Sandra ,  KEIL, Michael ,  WEVERS, Jan Hendrik ,  RACK, Michael ,  MAYER, Guido ,  PLESCHKE, Axel

    IPC分类号： C07C303/38 ,  C07C311/51 ,  C07C201/12 ,  C07C205/58 ,  C07C303/40

    CPC分类号： C07C303/38 ,  C07C201/12 ,  C07C303/40 ,  C07C311/51 ,  C07C205/58

    摘要： The invention relates to methods for producing sulfonamides of formula I, wherein the variables have the designations cited in the description, by reacting m-nitro-benzoic acid chlorides of formula II with aminosulfons of formula III, under the influence of B equivalents of base IV. Said method is characterised in that, during step a) the aminosulfon of formula III is reacted with B1 equivalents of base IV, and during step b), the reaction mixture resulting from step a) is reacted with m-nitro-benzoic acid chlorides of formula II and B2 equivalents of base IV; B, B1 and B2 having the designations cited in the description.

    摘要翻译： 本发明涉及制备式I磺酰胺的方法，其中这些变量在本说明书中引用的名称是通过式B的间硝基 - 苯甲酰氯与式III的氨基砜在B当量的碱IV的影响下反应 。 所述方法的特征在于，在步骤a）期间，式III的氨基磺与B1当量的碱IV反应，并且在步骤b）期间，将由步骤a）得到的反应混合物与间硝基苯甲酸氯化物 碱基IV的式Ⅱ和B2当量; B，B1和B2具有说明书中引用的标号。

    VERFAHREN ZUR HERSTELUNG VON SULFONSÄUREDIAMIDEN
    4.
    发明公开
    VERFAHREN ZUR HERSTELUNG VON SULFONSÄUREDIAMIDEN 审中-公开
    VERFAHREN ZUR HERSTELUNG VONSULFONSÄUREDIAMIDEN

    公开(公告)号：EP2200978A1

    公开(公告)日：2010-06-30

    申请号：EP08838788.1

    申请日：2008-10-10

    申请人： BASF SE

    发明人： PLESCHKE, Axel ,  SCHMIDT, Thomas ,  GEBHARDT, Joachim ,  LÖHR, Sandra ,  KEIL, Michael ,  WEVERS, Jan Hendrik

    IPC分类号： C07C303/34 ,  C07C307/06 ,  C07D239/54

    CPC分类号： C07C303/34 ,  A01N43/54 ,  C07C307/06 ,  C07C381/00 ,  C07D239/54

    摘要： The present invention relates to a method for producing sulfonic acid amines of the general formula (I) R1R2N-S(O)2-NH2 (I), where R1 and R2 are independent of each other and stand for a primary alkyl radical having 1 to 8 C atoms, a secondary alkyl radical having 3 to 8 C atoms, or a cycloalkyl radical having 5 to 8 C atoms, or, together with the nitrogen atom, form a 5- to 8-member saturated nitrogen heterocyclic compound that can comprise, in addition to the nitrogen atom, an additional hetero atom, selected from O and S, as a ring member, wherein the nitrogen heterocyclic compound is unsubstituted, or can comprise 1, 2, 3, or 4 alkyl groups each having 1 to 4 C atoms as substituents. The method comprises the following steps: i) conversion of a secondary amine of the formula (II) R1R2NH (II), where R1 and R2 have the meaning indicated above, having sulfuryl chloride in an inert, particularly aromatic, solvent in the presence of a tertiary amine, to form a sulfamoyl chloride of the formula (III) R1R2N-S(O)2-CI (III), where R1 and R2 have the meaning indicated above, and ii) conversion of the sulfamoyl chloride of the formula (III) obtained in step i) using ammonia, wherein in step ii) the sulfamoyl chloride of the formula (III) is used in the form of the solution obtained in step i) in the inert, particularly aromatic, solvent.

    摘要翻译： 本发明涉及通式（I）R 1 R 2 N-S（O）2 -NH 2（I）的磺酸胺的制备方法，其中R 1和R 2彼此独立并且代表具有1 具有3至8个C原子的仲烷基或具有5至8个C原子的环烷基，或者与该氮原子一起形成5至8元饱和氮杂环化合物，该化合物可包含 除了氮原子之外，还可以包含选自O和S的另外的杂原子作为环成员，其中氮杂环化合物是未取代的，或者可以包含1,2,3或4个各自具有1至4个 C原子作为取代基。 该方法包括以下步骤：i）将式（II）的仲胺在惰性溶剂，特别是芳香溶剂存在下转化其中R1和R2具有上述含义的式IIR2NH（II） 形成式（III）R 1 R 2 N-S（O）2 -Cl（III）的氨磺酰氯，其中R 1和R 2具有上述含义，和ii）将式 其中在步骤ii）中，式（III）的氨磺酰氯以在步骤i）中获得的溶液形式在惰性溶剂，特别是芳香溶剂中使用。

    VERFAHREN ZUR HERSTELLUNG VON DIFLUORMETHYLPYRAZOLYLCARBOXYLATEN
    5.
    发明授权
    VERFAHREN ZUR HERSTELLUNG VON DIFLUORMETHYLPYRAZOLYLCARBOXYLATEN 有权
    用于生产DIFLUORMETHYLPYRAZOLYLCARBOXYLATEN

    公开(公告)号：EP2086944B1

    公开(公告)日：2010-01-13

    申请号：EP07822162.9

    申请日：2007-11-02

    申请人： BASF SE

    发明人： RACK, Michael ,  SMIDT, Sebastian Peer ,  LÖHR, Sandra ,  KEIL, Michael ,  DIETZ, Jochen ,  RHEINHEIMER, Joachim ,  GROTE, Thomas ,  ZIERKE, Thomas ,  LOHMANN, Jan Klaas ,  SUKOPP, Martin

    IPC分类号： C07D237/04 ,  C07F7/04

    CPC分类号： C07D231/14

    摘要： The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-yl carboxylates of the formula (I) in which R1 is C1-C8-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl, etc.; and R2 is hydrogen, C1-C4-alkyl, benzyl or phenyl, wherein a) a compound of the general formula (II) in which X is fluorine, chlorine, or bromine, R1 has one of the definitions given above, and R4 is C1-C8-alkyl, C3-C8-cycloalkyl, C2-C8-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R3nSiCl(4-n) in which n is 1, 2 or 3 and the substituents R3 are each independently selected from C1-C8-alkyl and phenyl, and with a metal which is selected from the metals of groups 1, 2, 3, 4 and 12 of the periodic table and has a redox potential of less than -0.7 V, based on a standard hydrogen electrode (at 25°C and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula (III) in which R2 has one of the definitions given above.

    VERFAHREN ZUR HERSTELLUNG VON DIFLUORMETHYLPYRAZOLYLCARBOXYLATEN
    9.
    发明公开
    VERFAHREN ZUR HERSTELLUNG VON DIFLUORMETHYLPYRAZOLYLCARBOXYLATEN 有权
    VERFAHREN ZUR HERSTELLUNG VON二氟甲基吡唑聚氧乙烯醚

    公开(公告)号：EP2086944A1

    公开(公告)日：2009-08-12

    申请号：EP07822162.9

    申请日：2007-11-02

    申请人： BASF SE

    发明人： RACK, Michael ,  SMIDT, Sebastian Peer ,  LÖHR, Sandra ,  KEIL, Michael ,  DIETZ, Jochen ,  RHEINHEIMER, Joachim ,  GROTE, Thomas ,  ZIERKE, Thomas ,  LOHMANN, Jan Klaas ,  SUKOPP, Martin

    IPC分类号： C07D237/04 ,  C07F7/04

    CPC分类号： C07D231/14

    摘要： The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-yl carboxylates of the formula (I) in which R1 is C1-C8-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl, etc.; and R2 is hydrogen, C1-C4-alkyl, benzyl or phenyl, wherein a) a compound of the general formula (II) in which X is fluorine, chlorine, or bromine, R1 has one of the definitions given above, and R4 is C1-C8-alkyl, C3-C8-cycloalkyl, C2-C8-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R3nSiCl(4-n) in which n is 1, 2 or 3 and the substituents R3 are each independently selected from C1-C8-alkyl and phenyl, and with a metal which is selected from the metals of groups 1, 2, 3, 4 and 12 of the periodic table and has a redox potential of less than -0.7 V, based on a standard hydrogen electrode (at 25°C and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula (III) in which R2 has one of the definitions given above.

    摘要翻译： 本发明涉及制备式（I）的二氟甲基取代的吡唑-4-基羧酸酯的方法，其中R 1是C 1 -C 8烷基，C 3 -C 8环烷基，C 1 -C 4烷氧基-C 1 -C 4烷基， 烷基等; 其中a）通式（II）的化合物，其中X是氟，氯或溴，R1具有上述定义之一，且R4是氢，C1-C4-烷基，苄基或苯基， C1-C8-烷基，C3-C8-环烷基，C2-C8-链烯基，苄基或苯基与通式R3nSiCl（4-n）的硅烷化合物反应，其中n是1,2或3， R3各自独立地选自C1-C8-烷基和苯基，并且与选自元素周期表第1,2,3,4和12族的金属的金属并且具有小于-0.7V的氧化还原电势 ，基于标准氢电极（在25℃和101.325kPa下）; 和b）将来自步骤a）的反应混合物与通式（III）的化合物反应，其中R 2具有上述定义之一。