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    Process for manufacturing substituted 3-pyridylmethyl ammonium bromides
    2.
    发明公开
    Process for manufacturing substituted 3-pyridylmethyl ammonium bromides 审中-公开
    制备取代的3-吡啶基甲基溴化铵的方法

    公开(公告)号：EP2365965A1

    公开(公告)日：2011-09-21

    申请号：EP09755886.0

    申请日：2009-11-13

    Applicant: BASF SE

    Inventor： GEBHARDT, Joachim ,  MENGES, Frederik ,  RACK, Michael ,  KEIL, Michael ,  SCHRÖDER, Jochen ,  ORSTEN, Stefan ,  ZECH, Helmut ,  KLIMA, Rodney, F. ,  CORTES, David ,  LEICHT, Robert ,  YEGERLEHNER, Tony

    IPC: C07D213/80 ,  C07D401/04 ,  A61K31/44 ,  A61K31/4439

    CPC classification number: C07D401/04 ,  C07D213/80 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06

    Abstract: A process for manufacturing 5,6-disubstituted-3-pyridylmethyl ammonium bromides (I), wherein Q is a tertiary aliphatic or cyclic, saturated, partially unsaturated or aromatic amine; Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; Y and Y1 are each independently OR1, NR1R2, or when taken together YY1 is —O—, —S— or NR3—; R1 and R2 are each independently hydrogen, C1-C4 alkyl optionally substituted with C1-C4 alkoxy or phenyl optionally substituted with one to three C1-C4 alkyl groups, C1-C4 alkoxy groups or halogen atoms, or phenyl optionally substituted with one to three C1-C4 alkyl groups, C1-C4 alkoxy groups or halogen atoms; R3 is hydrogen or C1-C4 alkyl; comprises the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with bromine in the presence of a radical initiator in a solvent mixture comprising an aqueous phase and an organic phase, where the organic phase comprises a solvent selected from 1,2-dichloroethane, chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene and tetrachloromethane, and where the pH-value of the aqueous phase is from 3 to

    Abstract translation: 制备5,6-二取代-3-吡啶基甲基溴化铵（I）的方法包括以下步骤：（i）使式（II）化合物反应，得到3-溴甲基-5,6-二取代的吡啶化合物（ （ii）使式（III）的溴化合物与叔胺碱Q在溶剂中在约0℃至100℃的温度范围内反应。

    PROCESS FOR MANUFACTURING 5-FORMYL-PYRIDINE-2,3-DICARBOXYLIC ACID ESTERS
    6.
    发明公开
    PROCESS FOR MANUFACTURING 5-FORMYL-PYRIDINE-2,3-DICARBOXYLIC ACID ESTERS 有权
    用于生产5-甲酰基吡啶-2,3-二羧酸酯

    公开(公告)号：EP2376472A1

    公开(公告)日：2011-10-19

    申请号：EP09764528.7

    申请日：2009-12-07

    Applicant: BASF SE

    Inventor： RACK, Michael ,  GEBHARDT, Joachim ,  MENGES, Frederik ,  KEIL, Michael ,  KLIMA, Rodney F. ,  CORTES, David ,  LEICHT, Robert ,  ZECH, Helmut ,  SCHRÖDER, Jochen

    IPC: C07D401/04 ,  C07D213/80

    CPC classification number: C07D213/80

    Abstract: A process for manufacturing a 5-formyl-pyridine-2,3-dicarboxylic acid ester (I) wherein Z is hydrogen or halogen; Z
    1 is hydrogen, halogen, cyano or nitro and R
    1 , R
    2 are independently C
    1 -C
    10 -alkyl, comprising the steps of (i) reacting a compound of formula (II), wherein the symbols are as in formula (I), with a nitrosation agent (III) R
    3 -O-N=O (III) wherein R
    3 is C
    1 -C
    8 -alkyl, in the presence of an alkali metal or alkaline earth metal alcoholates or carbonates in a polar aprotic solvent at a temperature of from -45 to 40°C, to obtain an oxime compound (IV) where Z, Z
    1 , R
    1 and R
    2 are as in formula (I), and (ii) reacting oxime compound (IV) with an aliphatic C
    1 -C
    10 -aldehyde in the presence of a Lewis acid at a temperature in the range of from 0 to 100°C. The compounds of formula (I) are useful intermediates in the synthesis of herbicidal imidazolinones, like imazamox.

    PROCESS FOR MANUFACTURING 5-CHLOROMETHYL-2,3-PYRIDINE DICARBOXYLIC ACID ANHYDRIDES
    10.
    发明公开
    PROCESS FOR MANUFACTURING 5-CHLOROMETHYL-2,3-PYRIDINE DICARBOXYLIC ACID ANHYDRIDES 有权
    生产5-氯甲基-2,3-吡啶二羧酸酐的方法

    公开(公告)号：EP2358678A1

    公开(公告)日：2011-08-24

    申请号：EP09751875.7

    申请日：2009-11-03

    Applicant: BASF SE

    Inventor： MENGES, Frederik ,  GEBHARDT, Joachim ,  RACK, Michael ,  KEIL, Michael ,  KLIMA, Rodney F. ,  CORTES, David. ,  LEICHT, Robert ,  ZECH, Helmut ,  SCHRÖDER, Jochen

    IPC: C07D213/81 ,  C07D401/04 ,  C07D405/04

    CPC classification number: C07D491/048 ,  C07D213/803 ,  C07D213/81 ,  C07D401/04 ,  C07D405/04

    Abstract: A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) wherein Z is hydrogen or halogen; Z
    1 is hydrogen, halogen, cyano or nitro; comprising the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with a chlorinating agent, optionally in the presence of a radical initiator in a solvent selected from halogenated hydrocarbons, and (ii) crystallizing the compound (I) formed in step (i) from a solvent selected from chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, dichloroethane, trichloromethane, dichloromethane, toluene, xylenes, ethyl acetate, methyl tert.-butyl ether, and mixtures thereof. Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.

    Abstract translation: 一种制备其中Z是氢或卤素的5-氯甲基-2,3-吡啶二羧酸酸酐（Ⅰ）的方法; Z 1是氢，卤素，氰基或硝基; 包括以下步骤：（i）使式（II）化合物（其中符号具有式（I）中给出的含义）与氯化剂任选在自由基引发剂存在下在选自卤代烃， （ii）使步骤（i）中形成的化合物（I）从选自氯苯，1,2-二氯苯，1,3-二氯苯，1,4-二氯苯，二氯乙烷，三氯甲烷，二氯甲烷，甲苯，二甲苯 ，乙酸乙酯，甲基叔丁基醚及其混合物。 化合物（I）是合成除草咪唑啉酮的有用中间体。

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