公开(公告)号：EP2254142A3

公开(公告)日：2012-01-04

申请号：EP10005167.1

申请日：2010-05-18

申请人： BATTELLE MEMORIAL INSTITUTE

发明人： Tang, Keqi ,  Page, Jason S. ,  Kelly, Ryan T. ,  Smith, Richard D.

IPC分类号： H01J49/04 ,  H01J49/16

CPC分类号： H01J49/165 ,  H01J49/0431 ,  H01J49/066

摘要： The present invention relates generally to analytical instrumentation and more particularly to a low pressure electrospray ionization system and process for effective transmission of ions between coupled ion stages with low ion losses. An electrospray ionization (ESI) source is characterized by a first vacuum chamber enclosing both an ESI transmitter and a feed line for a supply gas, the first vacuum chamber having an exit orifice positioned at an entrance to a first ion guide enclosed in a second vacuum chamber, wherein a sample comprising electrospray ions is transmitted from the ESI transmitter to the ion guide through the exit orifice. Systems and methods are described which provide up to complete transmission of ions between coupled stages with low effective ion losses. An "interfaceless" electrospray ionization system is further described that operates an electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer. Furthermore, chambers maintained at different pressures can allow for more optimal operating conditions for an electrospray emitter and an ion guide.

公开(公告)号：EP2254142A2

公开(公告)日：2010-11-24

申请号：EP10005167.1

申请日：2010-05-18

申请人： BATTELLE MEMORIAL INSTITUTE

发明人： Tang, Keqi ,  Page, Jason S. ,  Kelly, Ryan T. ,  Smith, Richard D.

IPC分类号： H01J49/04 ,  H01J49/16

CPC分类号： H01J49/165 ,  H01J49/0431 ,  H01J49/066

摘要： The present invention relates generally to analytical instrumentation and more particularly to a low pressure electrospray ionization system and process for effective transmission of ions between coupled ion stages with low ion losses. An electrospray ionization (ESI) source is characterized by a first vacuum chamber enclosing both an ESI transmitter and a feed line for a supply gas, the first vacuum chamber having an exit orifice positioned at an entrance to a first ion guide enclosed in a second vacuum chamber, wherein a sample comprising electrospray ions is transmitted from the ESI transmitter to the ion guide through the exit orifice. Systems and methods are described which provide up to complete transmission of ions between coupled stages with low effective ion losses. An "interfaceless" electrospray ionization system is further described that operates an electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer. Furthermore, chambers maintained at different pressures can allow for more optimal operating conditions for an electrospray emitter and an ion guide.

摘要翻译： 本发明一般涉及分析仪器，更具体地涉及一种低压电喷雾离子化系统和用于在具有低离子损失的耦合离子级之间有效传输离子的方法。 电喷雾离子化（ESI）源的特征在于包围ESI发射器和用于供应气体的进料管线的第一真空室，第一真空室具有位于第一离子导管的入口处的出口孔，第一离子导管封闭在第二真空中 室，其中包含电喷雾离子的样品从ESI发射器通过出口孔传输到离子导向器。 描述了提供在具有低有效离子损失的耦合级之间完全传输离子的系统和方法。 进一步描述了一种“无接触”电喷雾电离系统，其以减压的方式操作电喷雾，使得标准电喷雾样品溶液可以直接喷射到提供离子聚焦和离子传输到质量分析器中的电动离子漏斗中。 此外，保持在不同压力的室可以允许电喷雾发射器和离子导向器更好的操作条件。

公开(公告)号：EP1265269A2

公开(公告)日：2002-12-11

申请号：EP02253364.0

申请日：2002-05-14

申请人： BATTELLE MEMORIAL INSTITUTE

发明人： Smith, Richard D. ,  Masselon, Christophe D. ,  Tolmachev, Aleksey

IPC分类号： H01J49/38

CPC分类号： H01J49/0009 ,  H01J49/38

摘要： A method for improving the calibration of a Fourier transform ion cyclotron resonance mass spectrometer wherein the frequency spectrum of a sample has been measured and the frequency ( f ) and intensity ( I ) of at least three species having known mass to charge ( m / z ) ratios and one specie having an unknown ( m / z ) ratio have been identified. The method uses the known ( m / z ) ratios, frequencies, and intensities at least three species to calculate coefficients A, B, and C, wherein the mass to charge ratio of a least one of the three species ( m / z ) i is equal to A f i + B f i ​ 2 + C · G ( I i ) f i ​ Q wherein f i is the detected frequency of the specie, G( I i ) is a predetermined function of the intensity of the specie, and Q is a predetermined exponent. Using the calculated values for A, B, and C, the mass to charge ratio of the unknown specie ( m /z) ii is calculated as the sum of A f ii + B f ii ​ 2 + C·G ( I ii ) f ii ​ Q wherein f ii is the measured frequency of the unknown specie, and ( I ii ) is the measured intensity of the unknown specie.

摘要翻译： 一种用于改进傅立叶变换离子回旋共振质谱仪的校准的方法，其中已经测量了样品的频谱，以及已知质量至少三种物质（）的频率（f）和强度（I） / z）比率，并且已经鉴定了具有未知（ / z）i等于A / fi + B / fi2 + CG（Ii）/ fi 其中fi是物种的检测频率，G（Ii）是预定函数的强度 specie，而Q是预定指数。 使用A，B和C的计算值，将未知物种（m / z）ii的质荷比计算为A / fii + B / fii2 + CG（Iii） / fii 其中fii是未知物种的测量频率，（Iii）是未知物种的测量强度。

公开(公告)号：EP1265269A3

公开(公告)日：2005-04-06

申请号：EP02253364.0

申请日：2002-05-14

申请人： BATTELLE MEMORIAL INSTITUTE

发明人： Smith, Richard D. ,  Masselon, Christophe D. ,  Tolmachev, Aleksey

IPC分类号： H01J49/38

CPC分类号： H01J49/0009 ,  H01J49/38

摘要： A method for improving the calibration of a Fourier transform ion cyclotron resonance mass spectrometer wherein the frequency spectrum of a sample has been measured and the frequency ( f ) and intensity ( I ) of at least three species having known mass to charge ( m / z ) ratios and one specie having an unknown ( m / z ) ratio have been identified. The method uses the known ( m / z ) ratios, frequencies, and intensities at least three species to calculate coefficients A, B, and C, wherein the mass to charge ratio of a least one of the three species ( m / z ) i is equal to A f i + B f i 2 + C · G ( I i ) f i Q wherein f i is the detected frequency of the specie, G( I i ) is a predetermined function of the intensity of the specie, and Q is a predetermined exponent. Using the calculated values for A, B, and C, the mass to charge ratio of the unknown specie ( m /z) ii is calculated as the sum of A f ii + B f ii 2 + C·G ( I ii ) f ii Q wherein f ii is the measured frequency of the unknown specie, and ( I ii ) is the measured intensity of the unknown specie.