公开(公告)号：EP0653943A4

公开(公告)日：1996-10-02

申请号：EP93917068

申请日：1993-07-09

申请人： BAYLOR COLLEGE MEDICINE

发明人： LEDLEY FRED D

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K47/48 ,  A61K48/00 ,  A61P29/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/705 ,  C07K14/715 ,  C12N5/10 ,  C12N9/06 ,  C12N9/12 ,  C12N9/14 ,  C12N15/113 ,  C12N15/85 ,  C12N15/87 ,  C12N15/88 ,  A61K39/395 ,  C12N15/90

CPC分类号： C12N15/1137 ,  A01K2217/05 ,  A01K2217/30 ,  A01K2227/107 ,  A01K2267/0306 ,  A01K2267/0325 ,  A01K2267/0368 ,  A61K38/00 ,  A61K47/645 ,  A61K48/00 ,  C07K14/705 ,  C07K14/715 ,  C12N9/0046 ,  C12N9/1211 ,  C12N9/14 ,  C12N15/8509 ,  C12N15/87 ,  C12N15/88 ,  C12Y114/99001

摘要： A method of transfecting a cell in a structure of a joint is disclosed, wherein a DNA vector containing a nucleic acid cassette encoding, for example, a cell ablation agent or a therapeutic agent, is directly injected into the joint. The invention also includes a transfected synovial cell.