公开(公告)号：EP4415742A2

公开(公告)日：2024-08-21

申请号：EP22881842.3

申请日：2022-10-14

申请人： Reverse Bioengineering, Inc.

发明人： WEST, Michael, D. ,  STERNBERG, Hal

IPC分类号： A61K38/17 ,  A61K38/16 ,  A61K48/00

CPC分类号： C12N15/86 ,  C12N2750/1414320130101 ,  C12N2830/00820130101 ,  C12N2740/1004320130101 ,  C12N2840/20620130101 ,  C12N2840/20320130101 ,  C12N2501/6020130101 ,  C12N5/0696 ,  C12N2506/130720130101 ,  C12N2501/60820130101 ,  C12N2501/60320130101 ,  C12N2501/60420130101 ,  C12N9/1211

公开(公告)号：EP3402496A1

公开(公告)日：2018-11-21

申请号：EP17738957.4

申请日：2017-01-12

申请人： Lonza Walkersville, Inc.

发明人： ABRAHAM, Eytan ,  PAYNE, Thomas ,  YOUNG, Robert, J. ,  FRIEDRICH BEN NUN, Inbar

IPC分类号： A61K35/545 ,  C12N5/00 ,  C12N5/04 ,  C12N15/63

CPC分类号： C12N5/0696 ,  A61K35/545 ,  C07K14/005 ,  C07K14/4702 ,  C12N9/1211 ,  C12N9/78 ,  C12N15/85 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2506/11 ,  C12N2510/00 ,  C12N2710/16231 ,  C12N2800/108 ,  C12N2820/60 ,  C12N2830/003 ,  C12N2830/006 ,  C12Y207/01021 ,  C12Y305/04001

摘要： The invention relates generally to methods of generating induced pluripotent stem cells (iPSCs) that do not contain the reprogramming vector. In some embodiments, the invention relates to inducing pluripotency in somatic cells by introducing an episomal vector(s) comprising at least one expression cassette containing reprogramming factors and/or synthetic transcription factors and a suicide gene. In some embodiments, the invention relates to inducing pluripotency in somatic cells by introducing episomal vector(s) comprising expression cassettes containing reprogramming factors and/or synthetic transcription factors and a transcriptionally regulated EBNA-1 gene. In some embodiments, the invention relates to inducing pluripotency in somatic cells by introducing episomal vector(s) comprising expression cassettes containing reprogramming factors and/or synthetic transcription factors and both a suicide gene and a transcriptionally regulated EBNA-1 gene.

公开(公告)号：EP2350295A1

公开(公告)日：2011-08-03

申请号：EP09748225.1

申请日：2009-10-08

申请人： Von Laer, Dorothee

发明人： LAER, Dorothee von ,  HEIMANN, Tsanan

IPC分类号： C12N15/86 ,  A61K35/76 ,  C12N5/10 ,  C12N5/074

CPC分类号： C12N15/86 ,  A61K48/005 ,  C07K14/005 ,  C07K14/52 ,  C07K14/5434 ,  C12N9/1211 ,  C12N2760/10022 ,  C12N2760/10023 ,  C12N2760/10032 ,  C12N2760/10033 ,  C12N2760/10044 ,  C12N2760/10045 ,  C12N2760/10122 ,  C12N2760/20222 ,  C12N2760/20223 ,  C12N2760/20241 ,  C12N2760/20243 ,  C12N2760/20245 ,  C12N2760/20252 ,  C12N2810/6072 ,  C12Y207/01021

摘要： The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocytic choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus-producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.

公开(公告)号：EP2148928A2

公开(公告)日：2010-02-03

申请号：EP08828368.4

申请日：2008-05-28

申请人： Wyeth LLC

发明人： WU, Stephen, Qitu ,  GILL, Michael, A. ,  CHU, Hsien-Jue

IPC分类号： C12N15/86

CPC分类号： C12N15/86 ,  A61K2039/5256 ,  C12N9/1211 ,  C12N2710/24043 ,  C12N2750/10034 ,  C12N2770/10034

摘要： The present invention relates to a new recombinant raccoon poxvirus vector vaccine in which the vector expresses one or more antigenic proteins encoded by multiple open reading frames, preferably the ORF5, ORF6 and/or ORF3/ORF4/ORF7, of one or more porcine reproductive and respiratory syndrome virus strains alone or in combination with an open reading frame of porcine circovirus type 2 (PCV-2), preferably ORF2, at the hemagglutinin (ha) and/or thymidine kinase (tk) loci.

公开(公告)号：EP1845094A4

公开(公告)日：2009-12-16

申请号：EP06700524

申请日：2006-01-04

申请人： UNIV KANAZAWA NAT UNIV CORP

发明人： MINAMOTO T

IPC分类号： C07D277/58 ,  A61K31/404 ,  A61K31/426 ,  A61P35/00 ,  C07D403/04 ,  C12N15/09

CPC分类号： C07D403/04 ,  A61K31/404 ,  A61K31/426 ,  C07D277/58 ,  C12N9/1211

公开(公告)号：EP1892291A1

公开(公告)日：2008-02-27

申请号：EP06017649.2

申请日：2006-08-24

申请人： Visgeneer, Inc.

发明人： Dai, Ken-Shwo

IPC分类号： C12N9/12

CPC分类号： C12N9/1205 ,  A61K39/00 ,  C12N9/1211

摘要： The invention relates to the nucleic acid and polypeptide sequences of three novel human Ron-related gene variants (Ron-V 1, Ron-V2, and Ron-V3). The invention also provides a process for producing the polypeptides of the variants, as well as uses for the nucleic acid, polypeptide and antibodies to same in diagnosing human breast carcinoma, breast adenocarcinoma, cervix epidermoid carcinoma, cervix epitheloid carcinoma, colon adenocarcinoma, urinary bladder carcinoma, prostate carcinoma, esophagus epidermoid carcinoma and esophagus carcinoma.

摘要翻译： 本发明涉及三种新的人类Ron相关基因变体（Ron-V 1，Ron-V2和Ron-V3）的核酸和多肽序列。 本发明还提供了一种制备变体多肽的方法，以及用于诊断人乳腺癌，乳腺癌，子宫颈表皮样癌，宫颈上皮样癌，结肠腺癌，膀胱中的核酸，多肽和抗体的用途 癌，前列腺癌，食管表皮样癌和食道癌。

公开(公告)号：EP0748631B1

公开(公告)日：2006-02-08

申请号：EP96108830.9

申请日：1989-09-13

申请人： Mérial

发明人： Ross, Louis Joseph Norman ,  Scott, Simon David ,  Binns, Matthew McKinley

IPC分类号： C12N15/38 ,  C12N15/86 ,  A61K39/255 ,  C07K14/055

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K39/255 ,  A61K2039/51 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C12N9/0093 ,  C12N9/1211 ,  C12N15/00 ,  C12N2710/16022 ,  C12N2710/16034 ,  C12N2710/16043 ,  C12N2710/16322 ,  C12N2710/16334 ,  C12N2710/16343

公开(公告)号：EP0753011B1

公开(公告)日：2004-09-01

申请号：EP95917536.5

申请日：1995-04-21

申请人： Eriksson, Staffan ,  Skog, Sven ,  Tribukait, Bernhard

发明人： Eriksson, Staffan ,  Skog, Sven ,  Tribukait, Bernhard

IPC分类号： C07K14/47 ,  C07K16/40 ,  G01N33/573 ,  G01N33/574

CPC分类号： C12N9/1211 ,  C07K14/47 ,  C07K16/40 ,  G01N33/573 ,  Y10S435/975 ,  Y10S436/813 ,  Y10S530/866

摘要： The invention discloses the use of a new cell growth related peptide. More precisely, the invention serves as a marker for cell proliferation. The marker is a peptide which is an exposed part of a cellular enzyme. This peptide is as well particularly useful as an aid in production of highly selective reactive molecules. The peptide is a part of thymidine kinase TK1 and has the sequence Lys-Pro-Gly-Glu-Ala-Val-Ala-Ala-Arg-Lys-Leu-Phe-Ala-Pro-Gln.

公开(公告)号：EP1253823A1

公开(公告)日：2002-11-06

申请号：EP00989488.2

申请日：2000-12-27

申请人： Liu, Chengyu

发明人： LIU, Chengyu ,  COSTANTINI, Franklin ,  WANG, Jin

IPC分类号： A01K67/00 ,  A01K67/033 ,  C12N5/00 ,  C12N5/02 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C12N15/85 ,  C12N15/87

CPC分类号： C12N9/1211 ,  A01K2217/05 ,  A01K2267/02 ,  C12N15/8509 ,  C12N2800/30 ,  C12N2830/00

摘要： A method for controlling the sex ratio of offspring by targeting transgenes. The method involves: (a) selecting or creating a transgene whose expression can interfere with sperm's ability to undergo fertilization, and whose gene products (mRNA and protein) do not diffuse freely among inter-connected spermatids; (b) placing the transgene under the regulatory control of post-meiotic spermatogenesis-specific promoter; and (c) using the transgene to generate transgenic animals in the way that the transgene is inserted onto one of the two sex chromosomes.

公开(公告)号：EP1159438A1

公开(公告)日：2001-12-05

申请号：EP00908116.7

申请日：2000-03-03

申请人： Introgene B.V.

发明人： VOGELS, Ronald ,  SCHOUTEN, Govert, Johan ,  BOUT, Abraham

IPC分类号： C12N15/861 ,  C12N15/62 ,  C12N15/34 ,  C12N9/12 ,  C12N5/10 ,  C07K14/075 ,  A61K48/00 ,  A61K38/45 ,  A61P19/02

CPC分类号： C12N7/00 ,  C07K14/005 ,  C12N9/1211 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10352

摘要： The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for fibroblast-like or macrophage-like cells, preferably synoviocytes. In one aspect said nucleic acid delivery vehicle is a virus capsid or a functional part, derivative and/or analogue thereof. Preferably said virus capsid is an adenovirus capsid. Preferably said adenovirus is a subgroup B adenovirus, preferably adenovirus 16. Preferably said tissue tropism is provided by at least a tissue tropism determining part of an adenovirus fiber protein or a functional derivative and/or analogue thereof. The invention further presents methods for the treatment of diseases, preferably joint related diseases.