利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.013 秒)

    Novel compounds
    2.
    发明公开
    Novel compounds 失效
    新化合物

    公开(公告)号：EP0363085A3

    公开(公告)日：1991-03-27

    申请号：EP89309920.0

    申请日：1989-09-28

    申请人： BEECHAM GROUP PLC

    发明人： Wadsworth, Harry John Beecham Pharmaceuticals ,  Hadley, Michael Stewart Beecham Pharmaceuticals ,  Wyman, Paul Adrian Beecham Pharmaceuticals ,  Jenkins, Sarah Margaret Beecham Pharmaceuticals

    IPC分类号： C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  A61K31/435 ,  A61K31/40

    CPC分类号： C07D471/08 ,  C07D453/02 ,  C07D487/08

    摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof:
    in which one of X and Y represents hydrogen and the other represents -CH₂-Z where Z is a group
    in which Q represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises one or two heteroatoms selected from oxygen, nitrogen and sulphur, or three nitrogen atoms, any amino nitrogen being optionally substituted by a C₁₋₂ alkyl, cyclopropyl or propargyl group, and any ring carbon atom being optionally substituted by a group R₁; or a group
    in which A₁, A₂ and A₃ complete a 5-membered aromatic ring and A₁ is oxygen or sulphur, one of A₂ and A₃ is CR₂ and the other is nitrogen or CR₃, or A₂ is oxygen or sulphur, one of A₁ and A₃ is CR₂ and the other is CR₃; and R₁, R₂ and R₃ independently selected from hydrogen, halogen, CN, OR₄, SR₄ N(R₄)₂, NHCOR₄, NHCOOCH₃, NHCOOC₂H₅, NHOR₄, NHNH₂, NO₂, COR₄, COR₅, C₂₋₄alkenyl, C₂₋₄ alkynyl, cyclopropyl or C₁₋₂ alkyl optionally substituted with OR₄, N(R₄)₂, SR₄, CO₂R₄, CON(R₄)₂ or one, two or three halogen atoms, in which each R₄ is independently hydrogen or C₁₋₂ alkyl and R₅ is OR₄, NH₂ or NHR₄; r represents an integer of 2 or 3, s represents an integer of 1 or 2 and t represents 0 or 1, with the proviso that when Y is hydrogen s is 1.

    摘要翻译： 式（Ⅰ）化合物或其药学上可接受的盐：其中X和Y中的一个代表氢而另一个代表-CH 2 -Z，其中Z是其中Q代表完成5-元杂环的3元二价残基的基团， 其包含一个或两个选自氧，氮和硫或三个氮原子的杂原子，任意氨基氮任选被C 1-2烷基，环丙基或炔丙基取代，并且任何环碳原子任选被 基团R 1; 或其中A 1，A 2和A 3完成5元芳族环并且A 1是氧或硫的基团，A 2和A 3中的一个是CR 2，另一个是氮或CR 3，或A 2是氧或硫，A 1和 A 3是CR 2，另一个是CR 3; （R 4）2，NHCOR 4，NHCOOCH 3，NHCOOC 2 H 5，NHOR 4，NHNH 2，NO 2，COR 4，COR 5，C 2-4链烯基，C 2-4炔基，环丙基， 或任意被OR 4，N（R 4）2，SR 4，CO 2 R 4，CON（R 4）2或1,2或3个卤素原子取代的C 1-2烷基，其中每个R 4独立地是氢或C 1-2烷基，R 5是OR 4 ，NH 2或NHR 4; r表示2或3的整数，s表示1或2的整数，并且t表示0或1，条件是当Y是氢时，s是1。

    Novel compounds
    3.
    发明公开
    Novel compounds 失效
    Chemische Verbindungen。

    公开(公告)号：EP0363085A2

    公开(公告)日：1990-04-11

    申请号：EP89309920.0

    申请日：1989-09-28

    申请人： BEECHAM GROUP PLC

    发明人： Wadsworth, Harry John Beecham Pharmaceuticals ,  Hadley, Michael Stewart Beecham Pharmaceuticals ,  Wyman, Paul Adrian Beecham Pharmaceuticals ,  Jenkins, Sarah Margaret Beecham Pharmaceuticals

    IPC分类号： C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  A61K31/435 ,  A61K31/40

    CPC分类号： C07D471/08 ,  C07D453/02 ,  C07D487/08

    摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof:
    in which one of X and Y represents hydrogen and the other represents -CH₂-Z where Z is a group
    in which Q represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises one or two heteroatoms selected from oxygen, nitrogen and sulphur, or three nitrogen atoms, any amino nitrogen being optionally substituted by a C₁₋₂ alkyl, cyclopropyl or propargyl group, and any ring carbon atom being optionally substituted by a group R₁; or a group
    in which A₁, A₂ and A₃ complete a 5-membered aromatic ring and A₁ is oxygen or sulphur, one of A₂ and A₃ is CR₂ and the other is nitrogen or CR₃, or A₂ is oxygen or sulphur, one of A₁ and A₃ is CR₂ and the other is CR₃; and R₁, R₂ and R₃ independently selected from hydrogen, halogen, CN, OR₄, SR₄ N(R₄)₂, NHCOR₄, NHCOOCH₃, NHCOOC₂H₅, NHOR₄, NHNH₂, NO₂, COR₄, COR₅, C₂₋₄alkenyl, C₂₋₄ alkynyl, cyclopropyl or C₁₋₂ alkyl optionally substituted with OR₄, N(R₄)₂, SR₄, CO₂R₄, CON(R₄)₂ or one, two or three halogen atoms, in which each R₄ is independently hydrogen or C₁₋₂ alkyl and R₅ is OR₄, NH₂ or NHR₄; r represents an integer of 2 or 3, s represents an integer of 1 or 2 and t represents 0 or 1, with the proviso that when Y is hydrogen s is 1.

    摘要翻译： 式（I）化合物或其药学上可接受的盐：其中X和Y中的一个代表氢，另一个表示-CH 2 -Z，其中Z是基团其中Q表示3元 二价残基完成5元芳环，并且包含一个或两个选自氧，氮和硫的杂原子，或三个氮原子，任选被C 1-2烷基，环丙基或炔丙基取代的任何氨基氮，以及任何环碳 任选被基团R 1取代的原子; 或其中A1，A2和A3完成5元芳环并且A1为氧或硫的基团，A2和A3之一为CR2，另一个为氮或CR 3，或A2为氧或硫，一 A1和A3是CR2，另一个是CR3; 和R 1，R 2和R 3独立地选自氢，卤素，CN，OR 4，SR 4 N（R 4）2，NHCOR 4，NHCOOCH 3，NHCOOC 2 H 5，NHOR 4，NHNH 2，NO 2，COR 4，COR 5，C 2-4链烯基，C 2-4炔基， 或任选被OR 4，N（R 4）2，SR 4，CO 2 R 4，CON（R 4）2或一个，两个或三个卤素原子取代的C 1-2烷基，其中每个R 4独立地是氢或C 1-2烷基，R 5是OR 4 ，NH2或NHR4; r表示2或3的整数，s表示1或2的整数，t表示0或1，条件是当Y为氢时，s为1。

    Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
    6.
    发明公开
    Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them 失效
    氮杂双环化合物，其制备方法和含有它们的药物组合物。

    公开(公告)号：EP0322182A2

    公开(公告)日：1989-06-28

    申请号：EP88312038.8

    申请日：1988-12-19

    申请人： BEECHAM GROUP PLC

    发明人： Orlek, Barry Sidney Beecham Pharmaceuticals ,  Wyman, Paul Adrian Beecham Pharmaceuticals ,  Wadsworth, Harry John Beecham Pharmaceuticals

    IPC分类号： C07D453/02 ,  C07D487/08 ,  A61K31/435 ,  A61K31/40

    CPC分类号： C07D487/08 ,  C07D453/02

    摘要： Novel compounds of formula (I), processes for their preparation, and their use as pharmaceutical agents are described:
    in which p represents an integer of 2 to 4; r represents an integer of 1 or 2; s represents 0 or 1; and X represents a group
    in which A₁ is oxygen or sulphur, one of A₂ and A₃ is CR₁ and the other is nitrogen or CR₂, or A₂ is oxygen or sulphur, A₁ is CH and A₃ is CR₁, where R₁ and R₂ are independently selected from hydrogen and C₁₋₂ alkyl, with the proviso that when r is 2, R₁ and R₂ are hydrogen or methyl.

    摘要翻译： 式（I）的新的化合物，它们的制备方法以及它们作为药物的用途进行了说明：其中p darstellt为2至4的整数; řdarstellt上的1或2整数; 小号darstellt 0或1; 和X darstellt一组中A 1是氧或硫，A2中的一个和A3是CR1且另一个是氮或CR 2，或A 2是氧或硫，A 1为CH和A 3是CR 1，其中R1和R2 独立地选自氢和C 1-2烷基，其条件没有当r是2，R1和R2是氢或甲基。

    Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
    8.
    发明公开
    Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them 失效
    杂环化合物，它们的制备方法和含有它们的药物组合物。

    公开(公告)号：EP0339834A2

    公开(公告)日：1989-11-02

    申请号：EP89303653.3

    申请日：1989-04-13

    申请人： BEECHAM GROUP PLC

    发明人： Hadley, Michael Stewart Beecham Pharmaceuticals ,  Orlek, Barry Sidney Beecham Pharmaceuticals ,  Wyman, Paul Adrian Beecham Pharmaceuticals ,  Wadsworth, Harry John Beecham Pharmaceuticals

    IPC分类号： C07D471/08 ,  C07D487/08 ,  A61K31/435 ,  A61K31/41

    CPC分类号： C07D471/08 ,  C07D487/08

    摘要： Novel compounds of formula (I), processes for their preparation, and their use as pharmaceutical agents are described:
    in which X represents a group
    wherein one of Y and Z represents nitrogen and the other represents CR where R is selected from halogen, CN, OR¹, SR¹, N(R¹)₂, NHR¹, NHCOR¹, NHCOOCH₃, NHCOOC₂H₅, NHOR¹, NHNH₂, COR¹, COR², C₂₋₄ alkenyl, C₂₋₄ alkynyl or C₁₋₂ alkyl substituted with OR¹, N(R¹)₂, SR¹, CO₂R¹, CON(R¹)₂ or one or two halogen atoms, in which R¹ is hydrogen or C₁₋₂ alkyl and R² is OR¹, NH₂ or NHR¹; and each of p and q independently represents an integer of 2 to 4.

    摘要翻译： 式（I）的新的化合物，它们的制备方法以及它们作为药物的用途进行了说明：其中x darstellt的基团 worin的Y一个和Z darstellt氮，其它的darstellt CR，其中R为 选自卤素，CN，OR <1>，SR <1>，N（R <1>）2，NHR <1>，NHCOR <1>，NHCOOCH3，NHCOOC2H5，NHOR <1>，NHNH 2，COR <1>中选择 ，COR <2>，C2-4链烯基，C 2-4炔基或具有或取代的C 1-2烷基<1>，N（R <1>）2，SR <1>，CO 2 <1>，CON（R < 1>）2或一个或两个卤素原子，其中R <1>是氢或C 1-2烷基且R <2>是或<1>，NH 2或NHR <1>; 且每个p和qunabhängigdarstellt至第四的2个整数的

    Bridgehead substituted azabicyclic derivatives
    9.
    发明公开
    Bridgehead substituted azabicyclic derivatives 失效
    桥头取代的氮杂双环衍生物

    公开(公告)号：EP0287356A2

    公开(公告)日：1988-10-19

    申请号：EP88303334.2

    申请日：1988-04-13

    申请人： BEECHAM GROUP PLC

    发明人： Hadley, Michael Stewart Beecham Pharmaceuticals ,  Wyman, Paul Adrian Beecham Pharmaceuticals ,  Orlek, Barry Sidney Beecham Pharmaceuticals

    IPC分类号： C07D471/08 ,  C07D487/08 ,  A61K31/435 ,  A61K31/40

    CPC分类号： C07D471/08 ,  C07D487/08

    摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof:
    in which X represents R₁OOC- in which R₁ is C₁₋₄ alkyl, C₂₋₄ alkenyl or C₂₋₄ alkynyl; R₂O- in which R₂ is C₁₋₂ alkyl, C₁₋₂ alkylcarbonyl or aminocarbonyl optionally substituted by one or two methyl groups;

    a group
    in which Y represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises one or two heteroatoms selected from oxygen, nitrogen and sulphur, any amino nitrogen optionally substituted by a C₁₋₂ alkyl group, Y being optionally C-substituted by a methyl group; or a group
    in which A₁ is oxygen or sulphur, one of A₂ and A₃ is CR₃ and the other is nitrogen or CR₄ where R₃ and R₄ are independently selected from hydrogen and methyl; and each of p and q independently represents an integer of 2 to 4.

    摘要翻译： 式（Ⅰ）化合物或其药学上可接受的盐：其中X代表R10OC-，其中R 1是C 1-4烷基，C 2-4链烯基或C 2-4炔基; R 2 O-（其中R 2是C 1-2烷基，C 1-2烷基羰基或氨基羰基，其任选地被一个或两个甲基取代） 其中Y代表完成5元芳族环并包含1或2个选自氧，氮和硫的杂原子的3元二价残基，任选被C 1-2烷基取代的氨基氮，Y任选为C 被甲基取代; 或其中A 1是氧或硫的基团，A 2和A 3之一是CR 3，另一个是氮或CR 4，其中R 3和R 4独立地选自氢和甲基; 并且p和q中的每一个独立地表示2至4的整数。